- Whole-brain cortical morphometry and structural covariance network disruption in subacute sclerosing panencephalitis. [Journal Article]AJNR Am J Neuroradiol. 2026 Oct 02. [Online ahead of print]AA
- CONCLUSIONS: SSPE produces widespread, duration-dependent cortical thinning and grey matter volume loss involving association, limbic and primary cortices. Group-level SCN topology showed a consistent directional pattern of network reorganisation that did not reach corrected statistical significance at this sample size. Prospective, longitudinal and multi-centre studies are required before any clinical application of these measures can be considered.
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- Prompt volumetric responses following preoperative embolization of skull base meningiomas: association with intratumoral contrast enhancement loss. [Journal Article]AJNR Am J Neuroradiol. 2026 Oct 02. [Online ahead of print]AA
- CONCLUSIONS: Preoperative embolization of skull base meningiomas was associated with early tumor volume reduction within days, although the magnitude of response varied substantially among tumors. Intratumoral contrast enhancement loss on post-embolization MRI was associated with greater tumor volume reduction and may serve as a semiquantitative imaging correlate of reduced tumor vascularity/perfusion after embolization.
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- Microstructural changes in deep gray nuclei following electroconvulsive therapy. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: RSI provides imaging biomarkers that suggest extracellular water shifts with corresponding volume changes to be the predominant effect of ECT. Transient and longer-term changes in glymphatic flow may be one of the contributing, underlying mechanisms of action for ECT.
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- Sex-Specific Regional Brain Morphometric Correlates of Neighborhood Socioeconomic Disadvantage in Clinical Neuroimaging. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: In a real-world clinical population, neighborhood-level socioeconomic disadvantage was associated with lower regional brain volumes across cerebellar, frontal/executive, and medial temporal/limbic neuroanatomical morphometric networks in male but not female patients; the cerebellar network was the only network to remain significant in interaction models. These findings suggest that the neuroanatomical correlates of neighborhood disadvantage may be sex-specific, and that sex-stratified analyses may be necessary to fully characterize the relationship between the social exposome and brain morphometry in clinical neuroimaging research.
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- Perivascular Spaces and Diffusion Tensor Imaging Analysis Along the Perivascular Space Show Distinct Associations with Aging and Alzheimer's Disease. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: In a single-scanner, acquisition-harmonized cohort, MRI-visible PVS burden was predominantly associated with older age, whereas a modest AD-associated reduction in ALPS emerged after covariate adjustment. PVS grading and ALPS characterize different structural and diffusion features and should not be considered interchangeable. Longitudinal validation with higher-resolution diffusion imaging is needed to determine whether ALPS provides additional clinical value.
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- Comparison of Pointwise Encoding Time Reduction with Radial Acquisition (PETRA) MR-Angiography with conventional MR-Angiography-Sequences for Follow-Up of intracranial Aneurysms in a real-world cohort. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: PETRA shows potential as a non-contrast MRA technique for follow-up of cerebral aneurysms, providing better vessel visibility than TOF and diagnostic performance comparable to ceMRA. However, its prolonged acquisition time and associated lower image quality currently limits clinical feasibility and real-world applicability. Further studies focusing on scan time reduction and cross-device performance are required.
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- Clinical outcomes of dynamic [[18]F]-FDG PET in focal epilepsy: a prospective early observational study. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: These findings suggest that dPET, by capturing metabolic rate rather than concentration, can identify regions that correspond to the EZ with a high degree of concordance in surgically confirmed cases, including many with nonlocalizing structural imaging. While this early phase study is not powered to establish diagnostic accuracy, the results support further investigation of dPET as a noninvasive adjunct for presurgical localization in focal drug-resistant epilepsy.
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- Spine MRI in Spontaneous Intracranial Hypotension: A Survey of Current State of Practice. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 29. [Online ahead of print]AA
- CONCLUSIONS: Current spine MRI protocols for SIH show substantial heterogeneity, particularly in fat-suppression technique and echo time, despite universal use of 3D T2-weighted imaging among surveyed centers. Ambiguous terminology further limits comparison across studies and may contribute to confusion regarding whether "MR myelography" refers to non-contrast heavily T2-weighted MRI or intrathecal contrast-enhanced MR myelography. Standardized terminology and more complete reporting of technical parameters are needed to improve interpretation of the literature and guide future protocol refinement.
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- Headache Outcomes After Flow Diversion or Coiling of Unruptured Intracranial Aneurysms: A Systematic Review and Meta-analysis. [Review]AJNR Am J Neuroradiol. 2026 Sep 28. [Online ahead of print]AA
- CONCLUSIONS: About one in three previously headache-free patients develops a new headache after endovascular treatment of a UIA, whereas roughly seven in ten with pre-existing headache improve, and worsening is uncommon. Estimates varied widely, partly with the timing of headache ascertainment; the available data are insufficient to establish whether flow diverters and coils differ.
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- Robotic-Assisted versus Manual Diagnostic Cerebral Angiography: Comparative Outcomes and Learning Curve in a Large Single-Institution Cohort. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 28. [Online ahead of print]AA
- CONCLUSIONS: RCA showed no statistically significant differences from manual DCA in terms of efficiency, contrast use, and safety, with a learning curve spanning around 50 cases.
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- Endovascular Thrombectomy for Minor Ischemic Stroke: A Machine Learning Study of Treatment Effect Heterogeneity. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 28. [Online ahead of print]AA
- CONCLUSIONS: EVT for minor LVO stroke was associated with higher mortality without improved routine discharge. Because some patients may be selected for EVT after deterioration, these are associations rather than causal effects. Individualized selection and randomized data are needed.
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- 3D Volume Rendering of Ultrahigh-Resolution Photon-Counting Detector CT Angiography for Preoperative Assessment of Intracranial Aneurysms: Initial Experience. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 28. [Online ahead of print]AA
- Three-dimensional volume rendering (3DVR) enables the detailed visualization of complex vascular anatomy. However, the utility of combining ultrahigh-resolution (UHR) photon-counting detector CT angiography (PCD-CTA) with 3DVR post-processing for preoperative intracranial aneurysm assessment has not yet been evaluated. This study explored whether combining UHR PCD-CTA with 3DVR post-processing pr…
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- Utility of the Spot Sign on Multiphase CT Angiography for Prediction of Hematoma Expansion in Intracerebral Hemorrhage. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 23. [Online ahead of print]AA
- CONCLUSIONS: Multiphase CTA uncovered a large group of ICH patients with spot signs appearing only on the second and third phases, at high risk of hematoma expansion. Initial and final phase spot sign characteristics, and their evolution, were associated with hematoma expansion. In comparison to single-phase CTA, using multiphase CTA enabled further identification of patients at high risk of hematoma expansion.
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- Diagnostic Yield of Repeat Myelography After an Initial Negative Study in Patients With Suspected Spontaneous Intracranial Hypotension. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 23. [Online ahead of print]AA
- CONCLUSIONS: After an earlier negative or nonlocalizing study, repeat myelography provided a definite or clinically supported localization in approximately 1 in 10 patients. Yield rose numerically with Bern score, but differences were not significant. All 3 definite localizations in the smaller secondary cohort were made with PCCT. Pressure- or exertion-provoked headache and saline augmentation warrant prospective evaluation.
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- Microvascular Perfusion Patterns and Intramedullary Arterial Resistance in Predicting Postoperative Recovery of Patients with Degenerative Cervical Myelopathy. [Journal Article]AJNR Am J Neuroradiol. 2026 Sep 22. [Online ahead of print]AA
- CONCLUSIONS: IOUS can be used as a non-invasive method to predict the postoperative recovery (PR) of DCM patients by indirectly assessing spinal cord perfusion pressure and intramedullary pressure. Type I (visible CSA) perfusion pattern may be associated with favorable outcomes, while type III (diffuse sparse) perfusion pattern may forebode poor PR. Elevated RI of CSA may indicate increased risk of incomplete neurological restoration.
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