- Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy. [Journal Article]Allergy. 2026 Sep 30. [Online ahead of print]A
- CONCLUSIONS: Compared to placebo, abatacept did not suppress the allergen-related induction of peanut-specific IgE relative to their total at 24 weeks, but improved OIT tolerability in this severely allergic adult population. Independently of abatacept, most participants achieved sustained unresponsiveness with OIT.
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- Co-Sensitization, Reactivity and Severity: Three Distinct Layers of Vicilin-Based Diagnosis. [Journal Article]Allergy. 2026 Sep 27. [Online ahead of print]A
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- Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition. [Journal Article]Allergy. 2026 Sep 27. [Online ahead of print]A
- CONCLUSIONS: Diagnosing EGPA presents a clinical challenge given its rarity and multiorgan presentation. A high clinical suspicion is required to ensure earlier recognition of this rare disease, including a thorough review of systems and appropriate laboratory workup, particularly in patients with treatment-resistant asthma, CRS, or eosinophilia.
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- Molecular Heterogeneity in Clinically Ambiguous Atopic Dermatitis-Psoriasis Overlap: Compartment-Resolved Transcriptomic Profiling. [Journal Article]Allergy. 2026 Sep 25. [Online ahead of print]A
- CONCLUSIONS: AD-PsO overlap lesions are molecularly heterogeneous and align toward AD-like or PsO-like inflammatory patterns. Compartment-resolved profiling provides a hypothesis-generating framework for molecular characterization of clinically ambiguous cases that merits validation in larger independent cohorts.
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- The EAACI Declaration of Salamanca: A European Roadmap for Strengthening Undergraduate Medical Education in Allergy and Clinical Immunology. [Review]Allergy. 2026 Sep 23. [Online ahead of print]A
- Allergic diseases are among the most prevalent chronic conditions in Europe, yet undergraduate medical curricula lack structured Allergy and Clinical Immunology (ACI) teaching. Moreover, desite advances in specialist education, postgraduate university training varies due to differences in specialty recognition, regulatory frameworks, and the implementation of the European Training Requirements. T…
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- Stool and Airway Microbiome Signatures Associated With Treatment Response to Dupilumab in Severe Asthma: Findings From the PRISM Study. [Journal Article]
- CONCLUSIONS: Gut and airway-derived microbiomes appear to play complementary roles in severe asthma. Stool-derived microbial features may reflect systemic inflammatory signals associated with treatment response, whereas airway-derived microbial profiles reflect local airway inflammation. Integrating multi-compartment microbiome data may improve the understanding of heterogeneity in biologic treatment response among patients with severe asthma.
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- Increased CEA Expression in Nasal Polyps Is Associated With Plasma Cell Infiltration. [Journal Article]Allergy. 2026 Sep 20. [Online ahead of print]A
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- Legends of Allergy and Immunology: Johannes Ring. [Journal Article]Allergy. 2026 Sep 18. [Online ahead of print]A
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- IgE-Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper. [Journal Article]Allergy. 2026 Sep 18. [Online ahead of print]A
- Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE-binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee. The aim of t…
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- IgE Sensitization Patterns of Mothers and Their Offspring in the First Five Years of Life The CHILD Study. [Journal Article]Allergy. 2026 Sep 16. [Online ahead of print]A
- CONCLUSIONS: These findings provide a comprehensive picture of IgE sensitization in this cohort. They also suggest a likelihood of loss of sensitization to key 2S albumins, which are excellent markers of food allergy with systemic reactions.
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- Single-Cell Profiling Links T-Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children. [Journal Article]Allergy. 2026 Sep 15. [Online ahead of print]A
- CONCLUSIONS: Distinct immunophenotypic profiles are associated with treatment response and disease activity in pediatric EoE. TS were associated with lower residual T cell infiltration than PPI. The evaluation of therapy-induced phenotypic changes by single-cell analysis was limited by low T cell yields in biopsies after TS treatment.
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- Algorithms in Allergy: Practical Approaches to Drug Desensitisation. [Journal Article]Allergy. 2026 Sep 15. [Online ahead of print]A
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- Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis. [Journal Article]Allergy. 2026 Sep 11. [Online ahead of print]A
- CONCLUSIONS: AD lesions contain spatially organized TLS-like immune niches at the dermal-epidermal junction, characterized by the close association of T cells and mmDCs and coordinated interactions with surrounding stromal and epithelial compartments. These mmDC-T cell niches may represent potential targets for future therapeutic strategies aimed at disrupting persistent local inflammatory pathways and improving long-term disease control.
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- Cumulative Vulnerability to Particulate Matter and Incident Asthma: Joint Effects of Urbanicity, Poverty, and Age in a Nationwide Cohort. [Journal Article]Allergy. 2026 Sep 11. [Online ahead of print]A
- CONCLUSIONS: Long-term PM exposure significantly increased asthma risk, with the greatest disparities observed among socioeconomically disadvantaged older adults residing in urban areas. Urgent, targeted strategies are needed to mitigate the disproportionate asthma burden attributable to these inequities.
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