This study evaluated the effectiveness of universal decolonization in intensive care units to decrease hospital-acquired Staphylococcus aureus infections (HA-SAI). HA-SAI (primary endpoint) decreased from 158 patients to 80 patients, infections per 1000 patient days decreased from 5.36 to 2.47, and in-hospital mortality was significantly lower in the post-group (32% vs 16%; p = 0.008). Universal decolonization is a successful way to decrease HA-SAI and reduce in-hospital all-cause mortality amongst adult ICU patients.

This pilot study evaluates the implementation of a High Consequence Infectious Disease (HCID) screening process using the "identify, isolate, and inform" (III) framework across three emergency departments in Minnesota. The study compares adherence rates from a COVID-19-specific screening baseline to broader, disease-nonspecific screenings. Findings indicate stable adherence rates, suggesting that incorporating HCID protocols into regular hospital operations can sustain compliance and streamline enhanced infection prevention processes. The screening tool guidance is available for public use.[1].