(Am J Ophthalmol[TA])
29,092 results
  • Structure-function associations in eyes with Early Atrophic Age-related Macular Degeneration. [Journal Article]
    Am J Ophthalmol. 2026 Sep 26. [Online ahead of print]Wei Y, Morobeid H, … Fleckenstein MAJ
  • CONCLUSIONS: In early atrophic AMD, lesion size and hypertransmission extent are closely linked to localized FCP sensitivity loss, whereas central visual acuity and reading outcomes are determined by lesion proximity to the fovea. This domain-specific separation supports targeted FCP as a sensitive endpoint for detecting structure-related functional change in early atrophic AMD.
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  • Organism-Specific Clinical Features and Outcomes of Culture-Positive Endogenous Endophthalmitis: A Multicenter Cohort Study Over 12 Years. [Journal Article]
    Am J Ophthalmol. 2026 Sep 26. [Online ahead of print]Kelly EC, Calderon R, … Fernando Arevalo JAJ
  • CONCLUSIONS: In this multicenter cohort, organism groups were associated with distinct presentations, sources, management, and outcomes. Low intraocular culture yield and imperfect concordance with blood cultures complicate pathogen-directed therapy. Presenting VA is the dominant prognostic factor, but gram-negative infections-particularly Serratia-carry markedly higher risk of globe loss. These findings support organism-informed clinical decision-making and highlight the need for improved intraocular diagnostics and targeted interventions.
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  • Cluster-Based Structural Phenotypes of Chronic Central Serous Chorioretinopathy. [Journal Article]
    Am J Ophthalmol. 2026 Sep 25. [Online ahead of print]Berni A, Scalabrin G, … Borrelli EAJ
  • CONCLUSIONS: Chronic CSC has a two-dimensional structure. Unsupervised clustering recovered the photoreceptor threshold that governs visual recovery and resolved a second, choroidal dimension that staging cannot represent, separating eyes staging treats as equivalent by choroidal thickness and age. Visual prognosis follows the photoreceptor axis alone. The 520-µm threshold is calibrated to pachychoroid-confirmed disease.
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  • Prevalence, Ocular Manifestations, and Treatment Response in Post-Bariatric Vitamin A Deficiency: A Systematic Review and Meta-Analysis. [Review]
    Am J Ophthalmol. 2026 Sep 24. [Online ahead of print]Abdel-Sayyed A, Bigam S, … Al-Ani AAJ
  • CONCLUSIONS: Among the procedures with adequate data, vitamin A deficiency is procedure-specific and common during pregnancy after RYGB. Ocular disease may present years to decades after surgery, but often improves when deficiency is recognized and treated. Certainty was limited by heterogeneity, the small number of cohorts for some procedure subgroups, and selective reporting of ocular outcomes. Nyctalopia, ocular surface disease, atypical outer retinal findings, or unexplained visual decline in a post-bariatric patient warrant prompt serum retinol testing and coordinated nutritional management regardless of the interval since surgery.
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  • EYS-associated retinal degeneration in South Korea: Genetic, Phenotype, and Natural History. [Journal Article]
    Am J Ophthalmol. 2026 Sep 23. [Online ahead of print]Jeon J, Surl D, … Lee CSAJ
  • CONCLUSIONS: This large multicenter study provides quantitative benchmarks for EZW and EZA progression in EYS-RD, with a relative EZW losses of approximately 4.6% per year and that may serve as reference endpoints for gene therapy trials. Despite linear structural decline, the absence of genotype-phenotype correlation underscores phenotypic heterogeneity and suggests that factors beyond the primary genetic defect contribute to disease variability.
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  • Incidence of De Novo Glaucoma and Ocular Hypertension After DMEK vs DSAEK: A Systematic Review and Meta-Analysis. [Review]
    Am J Ophthalmol. 2026 Sep 22. [Online ahead of print]Sadek K, Yu P, … Bhamra JAJ
  • CONCLUSIONS: De novo glaucoma and OHT are common after endothelial keratoplasty, and the overall pattern of lower event rates after DMEK persisted after adjustment for observation time. The magnitude attributable to technique remains uncertain, given variable glaucoma definitions, confounding by steroid exposure, and randomized evidence limited to ultrathin or microthin DSAEK. Larger head-to-head studies with standardized definitions and steroid protocols are needed.
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  • Predictors of Vision Loss and Surgical Intervention in Stevens-Johnson Syndrome: A Multicenter Nationwide Cohort Study. [Journal Article]
    Am J Ophthalmol. 2026 Sep 18. [Online ahead of print]Ortiz-Morales G, Barcelo-Canton RH, … Graue-Hernandez EOAJ
  • CONCLUSIONS: Chronic SJS often presents with advanced disease, frequent need for surgery, and progressive vision loss. Chronicity of disease and antibiotic or NSAID exposure predicted visual deterioration, while LMK and conjunctivalization predicted the need for surgery. Delayed referral and limited use of acute-phase therapies may contribute to poor outcomes, emphasizing the need for national guidelines for early referral, standardized care, and coordinated strategies to prevent avoidable vision loss.
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  • Photography-based Retinal Vasculometry and Visual Field Progression in Primary Open Angle Glaucoma. [Journal Article]
    Am J Ophthalmol. 2026 Sep 18. [Online ahead of print]Nishida T, Wang J, … Weinreb RNAJ
  • CONCLUSIONS: Baseline retinal vasculometry features were associated with subsequent longitudinal VF change after adjustment for demographic and clinical factors. These findings support further investigation of fundus photograph-derived vascular features as potential prognostic markers, although independent validation is needed before their clinical predictive utility can be established.
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  • Ultra-Widefield OCT Mapping of Foveal and Optic Nerve Head Topography Within Posterior Staphyloma in Pathologic Myopia. [Journal Article]
    Am J Ophthalmol. 2026 Sep 17. [Online ahead of print]Quarta A, Forte P, … Sadda SRAJ
  • CONCLUSIONS: UWF-OCT showed that PS in pathologic myopia is a spatially heterogeneous posterior pole deformation in which the fovea and ONH may occupy different topographic compartments. Whereas foveal position appeared relatively independent of conventional clinical parameters, ONH location and peripapillary atrophy were associated with both axial elongation and local staphyloma geometry, supporting distinct macular and peripapillary remodeling mechanisms in pathologic myopia.
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  • Recurrence of Hypertropia in Sagging Eye Syndrome. [Journal Article]
    Am J Ophthalmol. 2026 Sep 16. [Online ahead of print]Nunziata S, Yehezkeli V, … Demer JLAJ
  • CONCLUSIONS: Strabismus surgery effectively corrects hypertropia caused by SES, yet after about two years, roughly a quarter of patients develop delayed recurrent hypertropia, consistent with the progressive degenerative pathophysiology of SES. Surgical overcorrections are uncommon and may be overestimated due to compensatory progressive SES changes in the fellow eye.
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