- Ambulatory Episodic Hypertension in Parkinson's Disease With Orthostatic Hypotension. [Journal Article]Ann Neurol. 2026 Oct 24. [Online ahead of print]AN
- CONCLUSIONS: In patients with PD and neurogenic OH, ambulatory hypertensive episodes were associated with better clinical outcomes, an association not observed in patients with non-neurogenic OH. ANN NEUROL 2026.
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- Tornado-Like Enhancement in Primary Central Nervous System Lymphoma. [Journal Article]Ann Neurol. 2026 Oct 24. [Online ahead of print]AN
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- Accelerated Epigenetic Aging in Frontotemporal Dementia Highlights Smoking, Inflammation, and Metabolic Signals. [Journal Article]Ann Neurol. 2026 Oct 21. [Online ahead of print]AN
- CONCLUSIONS: Accelerated epigenetic aging in frontotemporal dementia is associated with GrimAge2-derived DNA methylation patterns linked to smoking, inflammation, and metabolic pathways. These findings raise the possibility that smoking-related DNA methylation reflects differences in smoking exposure or disease-related behavioral changes captured by GrimAge2. ANN NEUROL 2026.
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- A Recurrent 3'UTR Variant in CAPN3 Highlights the Diagnostic Impact of Non-Coding Variants in Limb-Girdle Muscular Dystrophies. [Journal Article]Ann Neurol. 2026 Oct 21. [Online ahead of print]AN
- CONCLUSIONS: Our results show that a recurrent non-coding CAPN3 variant causes disease by disrupting post-transcriptional regulation and demonstrate a generalizable principle, as 3'UTR variants can affect mRNA stability and protein expression across neuromuscular and other Mendelian diseases. Although often difficult to interpret as pathogenic, these variants can be therapeutically actionable, highlighting the importance of systematically investigating non-coding regions in unsolved genetic cases. ANN NEUROL 2026.
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- Salivary Dim-Light Melatonin Onset is Associated with Functional Decline, Respiratory Symptom Emergence, and Survival in Early Amyotrophic Lateral Sclerosis. [Journal Article]Ann Neurol. 2026 Oct 16. [Online ahead of print]AN
- CONCLUSIONS: Circadian phase alterations are detectable in early ALS. Baseline DLMO showed exploratory associations with functional, respiratory, and survival outcomes. Larger independent cohorts are required before DLMO can be considered a validated prognostic biomarker. ANN NEUROL 2026.
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- Activated Fibroblast Imaging in Baló's Concentric Sclerosis. [Journal Article]Ann Neurol. 2026 Oct 15. [Online ahead of print]AN
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- Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes. [Journal Article]
- CONCLUSIONS: Hemispheric asymmetry is common in early onset AD and correlates with clinical outcomes. Our longitudinal findings suggest a time-lagged asymmetry peak in amyloid, then tau, then atrophy. Taken together, our results position asymmetry as an important feature of AD heterogeneity, as it provides insight into disease mechanisms and trajectories. ANN NEUROL 2026.
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- Mild Amyloid Burden in the Brains of Cognitively Unimpaired Individuals is Associated with Long-Term Cognitive Impairment. [Journal Article]Ann Neurol. 2026 Oct 14. [Online ahead of print]AN
- CONCLUSIONS: Almost half of amyloid-negative cognitively unimpaired individuals were at an elevated long-term risk of cognitive impairment, when compared with those with the lowest amyloid levels. These findings suggest that the current threshold for amyloid positivity may be overly restrictive, potentially excluding a large portion of high-risk participants from prevention trials. ANN NEUROL 2026.
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- Interpreting Hyperacute IL-1β and NET Signals in Large-Vessel Occlusion Stroke. [Letter]Ann Neurol. 2026 Oct 14. [Online ahead of print]AN
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- Reply to "Interpreting Hyperacute IL-1β and NET Signals in Large-Vessel Occlusion Stroke". [Letter]Ann Neurol. 2026 Oct 14. [Online ahead of print]AN
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- 55th Child Neurology Society Annual Meeting. [Journal Article]Ann Neurol. 2026 Oct; 100 Suppl 36:S4-S229.AN
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- 151st Annual Meeting of the American Neurological Association. [Journal Article]Ann Neurol. 2026 Oct; 100 Suppl 37:S4-S375.AN
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- Cerebral No-Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment. [Journal Article]Ann Neurol. 2026 Oct 12. [Online ahead of print]AN
- CONCLUSIONS: Based on currently available literature and expert opinions, this Delphi study provides a framework for systematically reporting cerebral no-reflow after endovascular treatment (EVT). The variability in opinions regarding quantitative thresholds highlights priorities for future methodological standardization and validation studies. ANN NEUROL 2026.
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- Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology. [Journal Article]Ann Neurol. 2026 Oct 12. [Online ahead of print]AN
- CONCLUSIONS: We define actin-associated defects impacting astrocyte filopodia dynamics and motor neuron synaptic function in SMA. This shaped our therapeutic approach targeted to SMN-dependent and actin-related disease mechanisms, which overall demonstrated improvements in motor neuron function and disease pathology. ANN NEUROL 2026.
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- Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid-Positive Individuals. [Journal Article]Ann Neurol. 2026 Oct 09. [Online ahead of print]AN
- CONCLUSIONS: These findings identify severe EPVS-CSO as a strong predictor of first appearance of CAA-related hemorrhagic lesions in amyloid-positive individuals, supporting integration of amyloid biomarkers into magnetic resonance imaging-based Boston criteria. Identifying markers of the transition of CAA from a nonhemorrhagic to a hemorrhagic stage provides a potential foundation for approaching primary prevention of CAA-related hemorrhage. ANN NEUROL 2026.
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