- Postoperative Day 2 C-reactive Protein Identifies Patients at Low Risk of Anastomotic Leakage After Colon Cancer Resection. [Journal Article]Ann Surg. 2026 Oct 09. [Online ahead of print]AnnS
- CONCLUSIONS: POD2 CRP <100 mg/L, supplemented by selective POD3 reassessment, provides a simple algorithm to support safe early discharge after colon cancer resection within ERAS pathways.
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- Surgical Artificial Intelligence Innovation Trends and Regulatory Insights: A Systematic Analysis of Food and Drug Administration-Approved Devices. [Journal Article]Ann Surg. 2026 Oct 08. [Online ahead of print]AnnS
- CONCLUSIONS: FDA-approved surgical AI devices are currently dominated by imaging-based diagnostic tools.The widespread reliance on the 510(k) pathway and the observed prevalence of predicate creep highlight important considerations for regulatory evaluation. As AI applications expand toward predictive and interventional roles, improved evidence transparency and robust assessment of device equivalence will be essential to support safe clinical adoption.
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- The Cost of Uncertainty: Can We Afford to Miss Residual Disease? [Journal Article]Ann Surg. 2026 Oct 08. [Online ahead of print]AnnS
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- Pan-European Training Program for Robotic Pancreatoduodenectomy (LEARNBOT): Prospective Multicenter Study on Feasibility and Outcome. [Journal Article]Ann Surg. 2026 Oct 07. [Online ahead of print]AnnS
- CONCLUSIONS: We report on the first successfully completed international training program for RPD. Simulation established a standardized technical competency, although a learning-curve effect (major complications) remained detectable per center. These data highlight that safe adoption of complex procedures requires structured, team-based, proctored training beyond simulation alone.
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- Impact of Extent of Surgical Resection on Survival in Patients With High-risk Neuroblastoma: A Report From Children's Oncology Group ANBL0532. [Journal Article]Ann Surg. 2026 Oct 07. [Online ahead of print]AnnS
- CONCLUSIONS: CE of the primary tumor was associated with significantly higher EFS, OS, and decreased CILP, with no increase in surgical complications. As part of a comprehensive, multimodal treatment strategy, complete primary tumor resection when feasible is a critical component of therapy.
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- Impact of Side-to-Side Versus End-to-Side Gastrojejunostomy on the Rate of Delayed Gastric Emptying After Pancreatoduodenectomy (IPAD study): A Randomized Controlled Trial. [Journal Article]Ann Surg. 2026 Oct 05. [Online ahead of print]AnnS
- CONCLUSIONS: The present RCT found no significant difference in the rate of DGE between SSGJ and ESGJ. Postoperative outcomes, nutritional status, and quality of life were comparable, indicating that both techniques yielded comparable outcomes.
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- Well-being, Learning Environment, and Mistreatment Among Unionized Versus Nonunionized Surgery Residents During the COVID-19 Pandemic. [Journal Article]Ann Surg. 2026 Oct 02. [Online ahead of print]AnnS
- CONCLUSIONS: Unionization was not associated with improvements in resident well-being, the learning environment, or mistreatment during the pandemic, with the exception of a transient improvement in program responsiveness to resident concerns. These findings suggest that unionization alone may not be sufficient to protect resident wellness during periods of systemic stress.
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- The Impact of Robotics on Benchmarking Criteria for the Surgical Treatment of Esophageal Cancer in Western Centers- An Evaluation Using the IDEAL Framework. [Journal Article]Ann Surg. 2026 Oct 01. [Online ahead of print]AnnS
- CONCLUSIONS: The foundation of the international UGIRA registry has provided compelling evidence regarding standardized training pathways and guidelines and already serves as a scientific template for future technical evolution in upper GI surgery.
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- Liver Transplantation for Hepatocellular Carcinoma: Prognostic Impact of Complete Pathologic Response and Influence of Treatment Modality-A US National Database Study. [Journal Article]Ann Surg. 2026 Oct 01. [Online ahead of print]AnnS
- CONCLUSIONS: Nearly one-third of LT recipients with HCC achieved cPR, which was associated with improved survival. Y-90 was independently associated with higher cPR rates, particularly when administered early and among patients with higher tumor burden.
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- Axillary Nodal Upstaging in cT1N0 Invasive Lobular Carcinoma: Evaluating Applicability of SOUND Trial Results. [Journal Article]Ann Surg. 2026 Sep 28. [Online ahead of print]AnnS
- CONCLUSIONS: Among patients with SOUND-eligible ILC, 17.7% had axillary nodal metastasis and only 2.3% had extensive axillary nodal metastasis. These findings are comparable to the node-positive rates reported in the SLNB arm of the SOUND (13.7%) and INSEMA (15.1%) trials. High-risk features such as LVI and high grade were associated with nodal positivity.
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- Artificial Intelligence and the Future of Surgery. [Journal Article]Ann Surg. 2026 Sep 17. [Online ahead of print]AnnS
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- Patterns of Index Endovascular Compared With Surgical Revascularization for Femoropopliteal Disease in Patients With Claudication Using Medicare-linked Data. [Journal Article]Ann Surg. 2026 Sep 14. [Online ahead of print]AnnS
- CONCLUSIONS: Open bypass and endovascular intervention demonstrated similar long-term MALE and progression to CLTI through 5 years, suggesting endovascular intervention may offer comparable outcomes in appropriately selected patients with claudication.
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- Cost-effectiveness of Near-infrared Autofluorescence (NIRAF) in Total Thyroidectomy. [Journal Article]Ann Surg. 2026 Sep 11. [Online ahead of print]AnnS
- CONCLUSIONS: Cost-effectiveness of NIRAF is highly sensitive to the price and a payor's willingness-to-pay threshold as well as the true rate of transient or permanent hypocalcemia. To our knowledge, this is the first cost-effectiveness analysis of NIRAF during total thyroidectomy in the United States.
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- Perioperative Continuation of Code-status Limitations and Early Postoperative Mortality: A Retrospective Cohort Study. [Journal Article]Ann Surg. 2026 Sep 11. [Online ahead of print]AnnS
- CONCLUSIONS: Among adults presenting for a procedure with code-status limitations, continuation of a nonfull code status was associated with higher early postoperative mortality. This pattern reflects downstream clinical trajectories and treatment decisions rather than missed opportunities for perioperative rescue.
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- Why Open Surgery Must Live: Accompanying Laparoscopy to Its Death, A Reply to Kim et al. [Journal Article]Ann Surg. 2026 Sep 10. [Online ahead of print]AnnS
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