- Stromal α-smooth muscle actin-positive myofibroblasts in odontogenic keratocyst: A systematic review and network meta-analysis. [Review]Arch Oral Biol. 2026 Oct 15; 192:106780. [Online ahead of print]AO
- CONCLUSIONS: Higher stromal α-SMA-positive myofibroblast expression in OKC than DC, with no significant pooled difference from ameloblastoma, suggests a distinct contractile stromal phenotype. Their roles in matrix remodeling, contraction, and epithelial-stromal signaling provide biological rationale for further investigation. However, methodological heterogeneity and limited clinicopathological evidence preclude interpreting α-SMA expression as a marker or determinant of aggressive behavior or recurrence.
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- Oral microbiome profiles in a RUT-confirmed gastric H. pylori-positive cohort: A retrospective pilot comparison of specimen-processing workflows. [Journal Article]Arch Oral Biol. 2026 Oct 06; 192:106774. [Online ahead of print]AO
- CONCLUSIONS: Oral microbiome profiles differed among specimen-processing workflows. Buccal-swab and saliva-derived preparations provided complementary representations; however, because specimen type, preservation, and extraction procedures were not fully crossed, their individual contributions could not be separated. Standardized sampling and laboratory procedures are essential for reproducible oral microbiome studies.
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- Impact of tannins in presence or absence of saliva on the mucus layer of intestinal cells. [Journal Article]Arch Oral Biol. 2026 Oct 10; 192:106779. [Online ahead of print]AO
- CONCLUSIONS: The results suggest that interaction of polyphenols with saliva may have digestive consequences as far as in the intestine.
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- Prevalence of developmental defects of enamel in individuals with celiac disease: A systematic review and meta-analysis. [Review]Arch Oral Biol. 2026 Oct 09; 192:106775. [Online ahead of print]AO
- CONCLUSIONS: DDEs are frequently observed among individuals with celiac disease. Separate grade-specific meta-analyses yielded higher pooled estimates for milder DDE categories. However, the estimated prevalence varies considerably between populations and differs significantly according to the diagnostic criteria used to define DDE.
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- Fusobacterium nucleatum-induced endothelial ferroptosis promotes atherosclerosis. [Journal Article]Arch Oral Biol. 2026 Oct 07; 192:106776. [Online ahead of print]AO
- CONCLUSIONS: Fn-induced endothelial ferroptosis, accompanied by mitochondrial dysfunction and enhanced ER-mitochondria contacts, contributed to atherosclerosis progression. Ferroptosis inhibitors alleviated endothelial injury in vitro and in vivo, providing mechanistic evidence linking periodontal infection to cardiovascular disease and identifying ferroptosis as a potential therapeutic target.
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- Assessment of sexual dimorphism in adolescent palatal size and shape: Implications for sex estimation. [Journal Article]Arch Oral Biol. 2026 Sep 24; 192:106762. [Online ahead of print]AO
- CONCLUSIONS: Palatal traits demonstrate moderate sexual dimorphism and potential for sex estimation. Additional population-specific data remain essential for reliable forensic application.
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- Association between periodontitis and cytogenetic and cytotoxic damage in oral exfoliated cells: A systematic review with meta-analysis. [Review]Arch Oral Biol. 2026 Oct 06; 192:106777. [Online ahead of print]AO
- CONCLUSIONS: These findings support an association between periodontitis and increased mutagenicity in orally exfoliated cells, particularly binucleated cells, whereas evidence of cytotoxic damage remains inconclusive. The overall certainty of evidence ranged from very low to moderate.
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- Cranberry-coated mesoporous bioactive glass for bone tissue regeneration: Biofilm and osteogenic analysis in vitro. [Journal Article]Arch Oral Biol. 2026 Sep 30; 192:106773. [Online ahead of print]AO
- CONCLUSIONS: MBG-58S/CB reduced multi-species biofilms and increased ALP activity, indicating early osteogenesis without enhanced late mineralization. Cranberry-coated MBG-58S shows potential as a multifunctional biomaterial, though further studies are needed to optimize loading and assess late-stage bone regeneration.
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- Downregulation of IFT88 is associated with reduced primary cilia occurrence and clinicopathological progression in oral squamous cell carcinoma. [Journal Article]Arch Oral Biol. 2026 Sep 20; 192:106763. [Online ahead of print]AO
- CONCLUSIONS: Overall, reduced IFT88 and cilia may serve as potential biomarkers associated with OSCC progression and guide future cilia-related mechanistic studies.
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- Context-dependent roles of microRNA-21 in oral medicine: Established oncogenic relevance in OSCC and emerging regenerative potential in MRONJ. [Review]Arch Oral Biol. 2026 Sep 30; 192:106772. [Online ahead of print]AO
- CONCLUSIONS: Current evidence supports an asymmetric, context-dependent framework: miR-21 restoration in MRONJ remains an emerging preclinical regenerative strategy, whereas its oncogenic relevance in OPMDs and OSCC has a broader evidence base. Clinical translation requires tissue-specific, controlled modulation and careful consideration of oncological risk.
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- Effects of hydroxyapatite-containing oral care products on phosphoric-acid-etched enamel micro-morphology: Findings from erosion-relevant in vitro and in situ environments. [Journal Article]Arch Oral Biol. 2026 Sep 26; 192:106771. [Online ahead of print]AO
- CONCLUSIONS: HAP-containing oral care products did not show micro-morphological effects indicative of specific mineral deposition in any environment. The findings suggest that formulation-environmental interactions, potentially involving excipient-related effects, may influence the formation or persistence of precipitate-like surface structures.
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- Effects of methotrexate and biologic agents targeting the IL-23Th17 pathway on wound closure in human periodontal ligament fibroblasts: An in vitro study. [Journal Article]Arch Oral Biol. 2026 Sep 23; 192:106759. [Online ahead of print]AO
- CONCLUSIONS: Our preliminary findings indicate that methotrexate may delay wound healing to a greater extent than biological agents, likely due to its antiproliferative effects. Lower wound closure rates were observed in the methotrexate-treated group, whereas no significant difference was detected between the secukinumab and ustekinumab groups. Nevertheless, further studies should confirm these findings.
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- Bovine milk osteopontin induces cytokine release in buccal carcinoma cells. [Journal Article]Arch Oral Biol. 2026 Sep 20; 192:106764. [Online ahead of print]AO
- CONCLUSIONS: Bovine milk osteopontin at 600 μM demonstrated pro-inflammatory effects and may be relevant for tissue healing promotion.
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- Selective ecological modulation of multispecies subgingival biofilm by a non-alcoholic neovestitol-vestitol formulation. [Journal Article]Arch Oral Biol. 2026 Sep 18; 192:106770. [Online ahead of print]AO
- CONCLUSIONS: CNV-PL407 promoted selective ecological modulation of multispecies subgingival biofilms, impairing the recruitment of key periodontopathogens without extensive suppression of commensal species. These findings suggest that non-alcoholic neovestitol-vestitol delivery may represent a promising adjunctive strategy for periodontal biofilm control.
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- Pharmacological insights into advanced glycation end-product-associated vascular dysfunction and pulp calcification in type 2 diabetic rats. [Journal Article]Arch Oral Biol. 2026 Sep 20; 192:106768. [Online ahead of print]AO
- CONCLUSIONS: Pharmacological modulation of AGE-related pathways was associated with reduced intrapulpal calcification and pathological pulp changes in type 2 diabetic rats. These findings suggest that AGE-related processes potentially contribute to diabetic pulp pathology and warrant further investigation as likely therapeutic targets.
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