- Comparative effectiveness of dietary supplements in dilated cardiomyopathy: a systematic review and network meta-analysis. [Systematic Review]BMC Cardiovasc Disord. 2026 Aug 27; 26(1).BC
- CONCLUSIONS: In this network, higher-dose CoQ10 (150 mg/d) showed the most favourable overall profile for systolic function and ventricular dimensions, while n-3 PUFAs offered the most reliable benefit for heart rate. Given small samples, predominantly Chinese open-label trials, a heterogeneous and time-varying CT comparator, local inconsistency, and poor safety reporting, these findings should be regarded as hypothesis-generating and require confirmation in larger, well-designed international RCTs with longer follow-up.
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- Reliability and inter-device agreement of multi-site heart rate variability measurements during transcutaneous auricular vagus nerve stimulation: a prospective single-arm methodological physiological study. [Journal Article]
- CONCLUSIONS: Pre-post autonomic changes were broadly consistent across chest, fingertip, and upper-arm measurements, although inter-device agreement varied by HRV/PRV parameter. HR and RR interval showed excellent agreement, whereas RMSSD, SDNN, and frequency-domain indices were less consistent. Given the single-arm design, these findings should be interpreted as physiological measurement changes rather than causal effects of taVNS.
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- Association between triglyceride-glucose-related indices and cardiovascular disease risk in population with cardio-kidney-metabolic syndrome stages 0-3: a systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: This meta-analysis suggests that elevated TyG-derived indices are significantly associated with increased incident CVD risk among individuals with stage 0-3 CKM syndrome. Composite TyG-derived indices showed numerically higher pooled effect estimates than the TyG index; however, overlapping confidence intervals and the absence of direct statistical comparisons prevent conclusions regarding the superiority of any specific index. Given the observational nature of the included studies, limited population diversity, and substantial residual heterogeneity, these findings should be interpreted cautiously. TyG-derived indices may represent potential auxiliary markers for CVD risk stratification, and further large-scale multi-ethnic prospective studies are warranted to evaluate their clinical utility.
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- The p.Arg52Leu variant in GNB2 causes a gain-of-function due to an increase of IK, ACh in stimulated hiPSC-CMs. [Journal Article]
- CONCLUSIONS: The reported, mutant GNB2 in patient-derived CMs is associated with a gain-of function upon GIRK channel stimulation and thereby a larger IK, ACh, which could be potentially targeted and rescued by IK, ACh blockers.
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- Surgical outcomes of constrictive pericarditis and exploratory associations with inflammatory features: a 17-year single-center experience. [Journal Article]
- CONCLUSIONS: Pericardiectomy for constrictive pericarditis provided favorable short- and long-term outcomes in this single-center cohort. A study-defined preoperative inflammatory phenotype was associated with higher perioperative risk in this exploratory cohort. These preliminary findings highlight the potential role of perioperative inflammatory assessment in surgical patients, though validation in larger prospective registries is required.
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- Assessment of Cardiovascular Disease-Related Distress and Psychosocial Determinants: A Prospective Observational Study. [Journal Article]
- CONCLUSIONS: Cardiovascular disease-related distress among ACS patients varied across specific psychosocial domains rather than uniformly affecting all aspects of patient well-being. Distinct patterns of distress were observed across socioeconomic groups, highlighting the influence of psychosocial and socioeconomic determinants on cardiovascular distress. These findings emphasize the importance of identifying domain-specific distress to facilitate targeted and individualized patient care.
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- The merits of the prognostic nutritional index and neutrophil-to-lymphocyte ratio in predicting outcomes of coronary artery bypass grafting: a retrospective cohort study. [Journal Article]
- CONCLUSIONS: PNI is a simple and inexpensive marker that may serve as a potential predictor of short-term outcomes after CABG. Lower preoperative PNI and greater early postoperative PNI decline were associated with adverse short-term outcomes after CABG, whereas preoperative NLR did not retain independent significance after multivariable adjustment; however, further prospective multicenter studies are required to confirm these findings.
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- Prognostic effect of polypharmacy in ambulatory patients with heart failure: a machine learning-based analysis. [Journal Article]
- CONCLUSIONS: High polypharmacy is associated with reduced long-term survival in patients with heart failure. This highlights the need for personalized prescribing strategies to minimize the risks associated with polypharmacy while maximizing therapeutic benefits.
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- Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study. [Journal Article]
- CONCLUSIONS: This study revealed that TyG-related indices were associated with HTN-DM. RCS analysis indicated a linear association for TyG but nonlinear associations for TyG-BMI and TyG-BRI. Among the three indices, TyG showed the highest observed AUC. This finding suggests that composite indices incorporating BMI or BRI may not necessarily improve discriminative ability beyond TyG alone.
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- Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease. [Journal Article]
- CONCLUSIONS: RDW, HRR and RPR are associated with one-year mortality in ICU patients with hypertensive CKD. RDW exhibited modest predictive discrimination among the three markers and provides supplementary information for risk stratification when combined with established clinical risk scores. Prospective studies with external validation are warranted to confirm these findings and elucidate underlying mechanisms.
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- Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study. [Journal Article]
- CONCLUSIONS: This cross-sectional study demonstrated that TyG-BMI was independently and nonlinearly associated with EVA among young and middle-aged Chinese adults. The observed turning point suggests a potential reference point for this association. These findings suggest that TyG-BMI may serve as a simple, readily accessible indicator for assessing EVA risk in this population, pending external validation.
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- Disparities in the management of cardiogenic shock complicating acute myocardial infarction: a questionnaire survey in Beijing. [Multicenter Study]
- CONCLUSIONS: Significant disparities exist in the diagnosis and management of AMI-CS across different hospital levels in Beijing. There is an urgent need to enhance the understanding and management of AMI-CS, especially in Level 2 and Level 3 hospitals.
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- Left-sided 3D totally endoscopic mitral valve repair guided by left atrial appendage orientation in situs inversus totalis with mirror-image dextrocardia: a case report. [Case Reports]
- CONCLUSIONS: This case illustrates that valve-preserving, totally endoscopic mitral repair can be feasible in situs inversus totalis with mirror-image dextrocardia when imaging, cannulation, access and segment orientation are planned as a single operative strategy. The main educational message is that, in this case, the left atrial appendage served as a practical anatomical reference for maintaining segmental orientation during mitral repair in mirror-image anatomy.
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