- Prognostic value of OCT biomarkers and systemic factors for early and long term anatomical treatment response in diabetic macular edema. [Journal Article]BMC Ophthalmol. 2026 Sep 17; 26(1).BO
- CONCLUSIONS: Baseline OCT biomarkers showed candidate associations with anatomical response, but several, including the hyperreflective-material association, were not reproduced when the outcome was redefined using continuous final CMT or an absolute CMT threshold, despite robustness within the primary model. Discrimination was moderate (optimism-corrected AUC 0.75-0.76). These findings identify candidate prognostic OCT biomarkers requiring external validation before clinical application.
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- Clinical outcomes and baseline factors associated with one-year axial elongation during orthokeratology wear in children: a retrospective study. [Journal Article]
- CONCLUSIONS: Children undergoing orthokeratology showed a mean one-year axial elongation of 0.23 mm. Older age, higher baseline myopia, larger pupil diameter and BMI were associated with axial elongation during treatment, with notable sex differences. These findings may help inform individualized orthokeratology management in pediatric myopia.
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- Effectiveness of spectacle lenses with highly aspherical lenslets (HAL) in slowing axial elongation and spherical equivalent refraction progression in myopic and pre-myopic children: a systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: Current evidence suggests that HAL spectacle lenses may slow axial elongation and SER progression in myopic children. In pre-myopic children, HAL lenses may offer a smaller benefit, particularly with high adherence, but the evidence is limited and of low quality, precluding a strong recommendation for routine myopia prevention. Given the modest number of studies, short follow-up, and substantial heterogeneity, all findings warrant cautious interpretation.
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- Dislocated crystalline lens into the suprachoroidal space after blunt ocular trauma: a case report and diagnostic challenge. [Case Reports]BMC Ophthalmol. 2026 Oct 12; 26(1).BO
- CONCLUSIONS: Lens preservation is a feasible strategy in cases of posterior dislocation of the crystalline lens into the suprachoroidal space after closed-globe trauma, provided that the lens capsule remains intact and there is no evidence of inflammation or elevated intraocular pressure.
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- Combined vitrectomy/glaucoma drainage device with posteriorly placed tubes compared to anterior chamber placed tubes in children. [Journal Article]
- CONCLUSIONS: In children with glaucoma, concurrent Vit/GDD placement with posterior placement of the tube and aged-matched controls who underwent conventional anterior chamber GDD placement both obtained IOP control at final follow-up. Further, there was no difference in survival rates between the two groups.
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- A suture-induced granuloma of canaliculus after double eyelid surgery: a case report. [Case Reports]
- CONCLUSIONS: This case highlights that double eyelid surgery, if not performed according to strict operational standards, may cause injury to the lacrimal canaliculus and lead to complications. Clinicians should be aware of this rare but preventable condition.
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- Combined endoscope-assisted procedures (CEaP) for the management of neovascular glaucoma. [Journal Article]
- CONCLUSIONS: This combined surgical technique appears safe and effective and may represent a promising early interventional strategy for NVG, significantly reducing IOP and treatment burden in a high-risk patient population.
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- Efficacy and safety of XEN63 gel implant with open conjunctiva technique. [Multicenter Study]BMC Ophthalmol. 2026 Aug 05; 26(1).BO
- CONCLUSIONS: Open-conjunctiva XEN63 Gel Stent implantation resulted in significant reductions in IOP and medication burden during a short-term follow-up, with a favorable safety profile and low postoperative intervention rates, in both stand-alone and combined procedures.
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- TMT-based quantitative proteomic analysis of vitreous humor in proliferative diabetic retinopathy. [Journal Article]
- CONCLUSIONS: This study revealed significant alterations in the vitreous humor protein profile of PDR patients. The five identified candidate proteins (FV, PFN1, TXN, FTL, SeP) may serve as potential candidate biomarkers for PDR, providing new research directions and therapeutic targets for exploring the pathogenesis of PDR.
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- Evaluation of Bruch's membrane opening minimum rim width and retinal nerve fiber layer in patients with glaucoma and comparison with normal population. [Journal Article]
- CONCLUSIONS: BMO-MRW is a reliable and effective parameter for the early diagnosis of glaucoma, showing consistent global and sectoral diagnostic performance compared with APS-RNFL.
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- Orbital apex syndrome caused by imaging-occult sphenoid sinus fungal infection and the necessity of early surgical exploration: a retrospective case series. [Journal Article]
- CONCLUSIONS: For occult IFRS presenting with this striking 'clinical-radiological dissociation', early navigation-guided endoscopic exploration is a crucial sight-saving strategy. Strict glycemic control is paramount to preserving this therapeutic window. Further prospective validation is warranted.
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- Comparison of clinical outcomes after 25-gauge vitrectomy with and without uncomplicated cataract surgery for idiopathic epiretinal membrane. [Journal Article]
- CONCLUSIONS: Combined vitrectomy with uncomplicated cataract surgery may potentially be as effective as vitrectomy alone with respect to metamorphopsia and anatomical outcomes for IERM patients. However, the BCVA recovery was better in the Combined group.
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- Early outcomes of switching from bevacizumab to aflibercept-jbvf in exudative macular diseases: a real-world study. [Journal Article]
- CONCLUSIONS: Administration of aflibercept-jbvf following three monthly bevacizumab injections was temporally associated with a statistically significant but modest very early reduction in CST at 4 weeks in this heterogeneous cohort of exudative macular diseases. Because DME, neovascular AMD-related MNV, and RVO represent biologically and clinically distinct disease entities, the pooled findings should be interpreted as descriptive cohort-level estimates within this shared treatment pathway rather than as evidence of a uniform treatment effect across these conditions. A small numerical trend toward BCVA improvement was observed, but the change was not statistically significant in either the unadjusted or GEE-adjusted analysis. Because this was a single-arm study without a comparator group, the observed anatomical change cannot be attributed specifically to aflibercept-jbvf and may partly reflect a delayed or cumulative response to prior bevacizumab, regression to the mean, or natural variability in retinal thickness. Diagnosis-specific findings were exploratory, and the 4-week endpoint does not provide information regarding durability of response or longer-term treatment burden.
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- Time to diabetic retinopathy and its prognostic factors among adults with type 2 diabetes mellitus in Johor, Malaysia from 2015 to 2019: a retrospective cohort study using surveillance data. [Journal Article]
- CONCLUSIONS: Diabetic retinopathy develops within a relatively short duration following type 2 diabetes mellitus diagnosis and is influenced by a combination of metabolic, clinical, and complication-related factors. Early risk stratification and integrated management of modifiable risk factors are essential to delay the onset of diabetic retinopathy. These findings provide important real-world evidence to support targeted screening and public health strategies in Malaysia.
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