Recently, deep learning models in medical imaging have undergone tremendous advancements. However, these deterministic discriminative models often tend to overfit and produce overconfident predictions. To explore a more efficient strategy, we propose a diffusion-conditioned representation learning that leverages the internal dynamics of a diffusion model to extract noise-level awareness and diverse semantic representations in disease classification and detecting distributional shifts. The proposed method inherently encodes aleatoric uncertainty by sampling features from multiple denoising time steps, which is then used to regularize prediction during training via entropy regularized loss.

Canine distemper virus (CDV) is a pathogen that causes systemic infection in dogs and wildlife. Among the highly variable regions in the genome of the virus, the H gene is commonly sequenced for phylogenetic studies. The aim of the present study was to screen for the presence of CDV infection in dogs in Iran and to identify the genotype of the virus. Seventy-five dogs with gastrointestinal symptoms were screened via an immunochromatographic test. Fifty of them were positive. CDV was isolated from rectal swabs, and PCR was performed. The top 10 positive cases were subsequently selected for sequencing. Phylogenetic analyses were subsequently conducted. Among the 75 dogs analyzed, 50 (66.7%) dogs were found to be infected with CDV via rapid tests. All 10 sequenced isolates were from the Arctic lineage, forming a monophyletic cluster. Our sequences closely clustered with some European strains. Some nucleotide variations were observed. The present study reports the presence of Arctic-like CDV strains in diarrheic dogs in Tehran. Ongoing molecular surveillance will help in assessing any alterations in genetic diversity and vaccine efficacy. Future studies in other regions in Iran would be helpful.

This study examined whether feeling thermometer ratings toward older adults vary across older-adult subgroups and how such ratings are positioned relative to other common prejudice targets. Using an online sample of 520 Japanese adults aged 18-64, we assessed feeling thermometer ratings (0 = coldest, 100 = warmest) for 14 targets: nursing-home, on-deathbed, handicapped, solitary, senile, on-welfare, and grumpy older adults, as well as immigrants and refugees, foreign tourists, sexual minorities, racial minorities, and persons with mental, physical, or intellectual disabilities. We also tested whether these evaluations differed by participants' age group (younger and middle-aged adults).

Motivational orientation and immersive tendency describe complementary questionnaire-based dimensions of player characterization. Motivation instruments capture why players report engaging with games, whereas immersive-tendency instruments describe individual predispositions toward absorption, involvement, and attention focusing in mediated environments. To support reuse in questionnaire-based player modelling, we created an open, item-level, single-cohort survey dataset linking Bartle Test responses, ITQ-18 responses, demographics, and self-reported gaming preferences among IT students and teachers.

Lichen planus (LP) is a chronic inflammatory condition that can have systemic implications, including effects on vascular health. This exploratory study aimed to evaluate orbital hemodynamics and vascular changes in patients with mucosal LP using color Doppler ultrasound (CDU).

To describe the steps taken in the creation of a Data Pack containing clinical data from the FOCUS4 randomized controlled trial in colorectal cancer, representing a case study of clinical trial data access and sharing.

Hair plays multiple biological, psychosocial, and cultural roles, impacting psychological well-being and contributing to a rapidly expanding hair care market. This study aimed to validate a questionnaire assessing hair health and care (HHCQ) among young adults.

This study aimed to evaluate the individual and combined effects of silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and iron oxide nanoparticles (Fe3O4-NPs) on wound healing in a rat model of infection with Acinetobacter baumannii and Escherichia coli, and to compare their efficacy with a standard antibiotic treatment.

Chronic sleep deprivation (SD) and caffeine consumption individually impair male reproductive function; however, the combined impact of simultaneous exposure on reproductive neuroendocrinology remains largely unexplored. This study investigated the effects of concomitant exposure to a novel Unpredictable Chronic Sleep Deprivation (CUSD) paradigm and high-dose caffeine on hypothalamic monoaminergic neurotransmission, seminal indices, and hypothalamic-pituitary-adrenal/gonadal (HPA/HPG) axis activity in adult male Long-Evans rats.

To evaluate domain-specific quality of life and its associations with functional severity, selected comorbidities, and social factors among children with cerebral palsy attending a tertiary referral centre in Sri Lanka.

To evaluate the impact of implementing a daily target sheet on meeting quality indicators and reducing healthcare-associated infections caused by multidrug-resistant organisms in an adult intensive care unit.

Finding novels ways to deliver digital health behaviour interventions could increase their reach and impact. The aim of this study was to evaluate the feasibility of using a home-telemonitoring system (offered to eligible patients by regional authorities in Sweden for symptom- and health marker monitoring) as a novel dissemination opportunity. The intervention has been previously found effective at changing health behaviours in a general online help-seeking population. In the present study, participants were not randomised: all had access to the intervention (pre-post analyses).

Metadata standardization in collaborative biomedical research must balance interoperability with domain-specific detail. We describe a parent-template approach in which a baseline schema from the nephrology-focused CRC 1453 NephGen was adapted for the tumor-immunology CRC OncoEscape and the perinatal-immunology CRC Pilot.