- D-Dimer Dynamics as a Prognostic and Monitoring Biomarker in Triple-Negative and Metastatic Breast Cancer: A Narrative Review. [Review]Breast Cancer (Dove Med Press). 2026; 18:637558.BC
- CONCLUSIONS: D-dimer dynamics represent a promising, accessible component of multimodal precision oncology, but should not independently diagnose progression, select anticancer therapy, or determine anticoagulation. Prospective multicentre studies are needed to standardize assays, validate trajectory-based thresholds, integrate D-dimer with multi-omics and artificial intelligence, and determine whether D-dimer-guided monitoring improves outcomes, particularly in resource-constrained settings and diverse African oncology populations globally appropriately.
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- Beyond the Small Incision: The Value of Endoscopic and Robotic Mastectomy. [Editorial]Clin Breast Cancer. 2026 Sep 10. [Online ahead of print]CB
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- Target trial emulation of first-line ribociclib versus palbociclib in hormone receptor-positive, HER2-negative metastatic breast cancer: a comparative effectiveness study. [Journal Article]
- CONCLUSIONS: Both co-primary analyses showed an association with longer overall survival for ribociclib, with attenuation in the calendar-restricted analysis (HR 0.90, 95% CI 0.82-0.99). These findings are hypothesis-generating, not evidence of superiority, and require randomized confirmation.
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- Cytoplasmic Basigin Localization is Associated with EMT, Tumor Budding, and Adverse Prognosis in Breast Cancer. [Journal Article]Breast Cancer (Dove Med Press). 2026; 18:631016.BC
- CONCLUSIONS: Basigin subcellular redistribution is significantly associated with EMT-associated phenotypes, tumor budding, and adverse prognosis in breast cancer. Assessment of Basigin localization may provide additional prognostic value beyond conventional clinicopathological parameters. A nomogram integrating Basigin localization, tumor budding, histological grade, and molecular subtype may facilitate individualized risk stratification in patients with breast cancer, pending external validation in independent cohorts.
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- Preoperative CA15-3 as a predictor of axillary lymph node metastasis and prognosis in women with breast cancer: a GRADE-assessed systematic review and meta-analysis. [Review]
- CONCLUSIONS: Elevated preoperative CA15-3 is significantly associated with reduced survival and increased ALNM risk. This association remained significant after adjustment for tumor characteristics in most primary studies, suggesting CA15-3 may reflect more aggressive tumor biology. These findings support CA15-3's potential as an adjunctive biomarker; however, prospective validation is warranted.
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- Pharmacological Myristoylation Inhibition by Zelenirstat Disrupts Growth Signalling, Energy Metabolism, and Migration in Triple-Negative Breast Cancer Cells. [Journal Article]
- CONCLUSIONS: In addition to the previously shown inhibitory effect of zelenirstat on TNBC cell growth in vitro and in vivo, our new data demonstrate the widespread effects of zelenirstat on both aggressive TNBC cells and BCSCs. These findings highlight the potential of zelenirstat as an anti-metastatic agent, warranting further clinical trial evaluation in patients with TNBC.
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- Re-excision in Ductal Carcinoma In Situ: Comment on Dorten et al., "Re-excision in Ductal Carcinoma In Situ Is Not Associated With Improved Local Control". [Letter]Clin Breast Cancer. 2026 Sep 11. [Online ahead of print]CB
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- The Immunomodulatory Effect of Various Anesthetic Factors and Techniques on Patients Undergoing Breast Cancer Surgery: A Systematic Review and Meta-analyses of RCTs. [Review]Clin Breast Cancer. 2026 Sep 11. [Online ahead of print]CB
- Breast cancer is the most common type of cancer among women, while several factors seem to play a role in carcinogenesis. Recent findings suggest that some anesthetic factors and techniques contribute to immune suppression and metastasis, while others have beneficial effects. The aim of this meta-analysis is to identify the overall effects of different anesthetic modalities on the patients' immun…
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- Long-term outcomes of invasive lobular carcinoma compared with invasive ductal carcinoma in HR-positive/HER2-negative breast cancer: a focus on luminal subtypes. [Journal Article]
- CONCLUSIONS: ILC tended to be associated with poorer long-term invasive outcomes than IDC, particularly in HR-positive/HER2-negative disease. The adverse prognostic association of ILC was more apparent in luminal B-like tumors than in luminal A-like tumors. These findings support a risk-adapted approach to ILC that integrates histology, tumor burden, and proliferative activity. Further validation in larger prospective studies is warranted.
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- Effects of exercise and educational programs on long-term quality of life, anxiety, and depression in breast cancer survivors: an exploratory secondary analysis of the Setouchi breast project-10 randomized controlled trial. [Journal Article]
- CONCLUSIONS: This exploratory secondary analysis suggests that physician-led educational interventions and structured exercise may contribute to maintaining breast cancer-specific HRQoL, particularly in disease-specific domains. However, global HRQoL and psychological outcomes did not show consistent improvements, and a tendency toward deterioration was observed in some indicators for the exercise group at 12 months. These findings should be interpreted with caution, but they suggest that low-cost educational approaches could be a resource-efficient option in survivorship care.
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- Core Outcome Set Measures Are Underreported in Breast Cancer Randomized Clinical Trials: A Cross-Sectional Study. [Journal Article]Clin Breast Cancer. 2026 Sep 10; 26(11):9-16. [Online ahead of print]CB
- CONCLUSIONS: As PROs and patient-centered healthcare are coming to the forefront of medicine, particularly in oncology, a standardized COS, like ICHOM's, offers trialists an endorsed resource to thoroughly capture and report the patient perspective in clinical research. We have offered recommendations to improve the reporting of PRO measures to capture within breast cancer RCTs.
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- Incidence and Treatment Patterns of Pleomorphic Lobular Carcinoma in Situ: A Population-based Analysis After the Introduction of ICD-O-3 Code 8519/2. [Journal Article]Clin Breast Cancer. 2026 Sep 08; 26(11):1-8. [Online ahead of print]CB
- CONCLUSIONS: PLCIS is investigated and irradiated more intensively than classic disease; surgical extent differs little. Because the exposure relies on registrar transcription without central pathology review, and SEER cannot show why radiotherapy was given, these data describe practice rather than justify it. They do not support changing individual management, but call for prospective study recording central review, margin status and treatment indication.
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- Pathological Complete Response and Safety of Neoadjuvant Pembrolizumab-Based Chemoimmunotherapy in Triple-Negative and Hormone Receptor-Low Breast Cancer: A Real-World Cohort Study. [Journal Article]Breast Cancer (Dove Med Press). 2026; 18:636314.BC
- CONCLUSIONS: In this real-world Middle Eastern cohort, pembrolizumab-based chemoimmunotherapy achieved pCR rates consistent with pivotal trial data. Grade 3 histology, pathogenic germline mutation, and age younger than 40 years were independently associated with pCR; the HR-low findings are exploratory. These results support prospective biomarker-driven trials in early TNBC across underrepresented populations.
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- Mindful eating as a supportive intervention for breast cancer survivors: a pilot randomized controlled trial. [Journal Article]Breast Cancer. 2026 Sep 27. [Online ahead of print]BC
- CONCLUSIONS: Both TAU and TAU + MEI were associated with improvements in selected eating-behavior and anthropometric outcomes over time, including indicators of central adiposity, with no clear overall superiority of TAU + MEI across the outcomes assessed. These exploratory findings support further investigation of incorporating mindful eating into standard nutritional care for breast cancer survivors.
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- Investigation of the Residual Tumor Burden and Prognosis of Breast Cancer. [Journal Article]
- CONCLUSIONS: Within this historical cohort, the RCB index provides valuable prognostic information, effectively stratifying institutional patients based on recurrence and metastasis risk. While its routine adoption in clinical practice is supported to complement risk stratification, conclusions regarding its universal independent value across all classes are bounded by the low number of RCB-0 and RCB-I cases.
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