- The Effect of Clinicopathological Features and Postoperative Management on Prognosis in Male Breast Cancer. [Journal Article]Breast J. 2026; 2026(1):e2806453.BJ
- CONCLUSIONS: The median age at diagnosis for MBC patients in China was significantly younger compared to other populations. Postoperative chemotherapy significantly improved OS in patients with positive axillary lymph nodes and primary lesions exceeding 2 cm. Postoperative radiotherapy demonstrated survival benefits in partial early-stage and locally advanced patients. Additionally, surgery at the primary site represented a viable therapeutic option for selected Stage IV patients.
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- Comparison of Modified Pectoral Nerve Block and Erector Spinae Plane Block for Postoperative Analgesia and Surgical Stress Response Following Modified Radical Mastectomy: A Prospective, Randomised, Blinded Study. [Randomized Controlled Trial]
- CONCLUSIONS: PECS-II provided longer postoperative analgesia than ESPB in patients undergoing MRM under GA. Exploratory analyses showed lower postoperative analgesic consumption, lower pain scores at 6 h, lower postoperative stress response markers and higher patient satisfaction with PECS-II. These secondary findings should be considered hypothesis-generating and warrant confirmation in larger, adequately powered studies. Intraoperative fentanyl requirement was comparable between the two groups.
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- Lower-Cost Nonsurgical Primary Prevention Strategies for Women at High Risk of Breast Cancer: A Scoping Review. [Journal Article]
- CONCLUSIONS: This scoping review systematically maps lower-cost, nonsurgical primary prevention strategies for women at high risk of breast cancer, identifying six categories of promotable interventions. Comprehensive lifestyle intervention represents the most evidence-supported and economically manageable core strategy. For the first time from the dual perspectives of "nonsurgical" and "lower cost," this review provides practical references for primary healthcare systems, clinical education, and public health policy, with particular relevance for resource-limited settings.
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- Association of CYP3A5 Genetic Variants With Elevated Breast Cancer Risk: A Case-Control and In Silico Analysis. [Journal Article]
- CONCLUSIONS: The findings indicate that the CYP3A5∗3 polymorphism may contribute to genetic susceptibility to breast cancer among Bangladeshi women. Additionally, CYP3A5 expression shows a relationship with immune infiltration and may have subgroup-specific prognostic relevance in breast cancer.
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- Is Neoadjuvant Chemotherapy Necessary for Male Breast Cancer? A SEER-Based Population Study. [Journal Article]
- CONCLUSIONS: This population-based study demonstrates that MBC patients receiving NAC achieved significantly lower pCR rates compared to female patients. The HR+/HER2- and HR+/HER2+ subtypes exhibited greater resistance to NAC. Furthermore, achieving pCR was not prognostic for improved survival in MBC. These findings suggest that NAC may not be necessary for all MBC cases. Future research should explore alternative treatment strategies tailored to the unique biological characteristics of MBC.
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- Assessing the Effect of Breast Density on Screening Performance in a Population-Based Program. [Journal Article]
- CONCLUSIONS: The effectiveness of conventional two-dimensional mammography is strongly dependent on breast density, with reduced sensitivity and increased interval cancer rates for clients with extremely dense breasts. By utilising a more granular measure of breast density in a large population screening cohort, this study identified nonlinear relationships between breast density and screening performance metrics, providing evidence to support future evaluation of more individualised screening approaches.
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- Study on the Pathway Mechanism of Social Support and Quality of Life Between Self-Disclosure and Stigma Among Breast Cancer Patients During Recovery. [Journal Article]
- CONCLUSIONS: Breast cancer patients exhibit relatively low self-disclosure and moderate-to-low stigma. Higher self-disclosure is associated with lower stigma directly or indirectly via the chain mediation of social support and quality of life. Enhancing psychological counseling, social support, and quality of life, paired with targeted interventions for education and personality subgroups, facilitates physical and mental recovery and social reintegration.
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- Inhibition of miR-301a-3p Expression Promotes Ferroptosis: A New Target for Ferroptosis Treatment in TNBC. [Journal Article]
- CONCLUSIONS: In conclusion, this study provides evidence that inhibition of miR-301a-3p expression promotes ferroptosis in TNBC cells and produces a synergistic anti-cancer effect with Erastin, providing a new target for future TNBC ferroptosis treatment strategies.
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- An Algorithm for Salvage of Implant-Threatening Complications in Breast Reconstruction. [Journal Article]
- CONCLUSIONS: A protocol-based salvage approach may facilitate implant preservation and improve final reconstruction rates. Early, case-specific conservative management, tailored to local microbiologic patterns, may optimize outcomes.
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- Integrating Serum Lipid Biomarkers Into Machine Learning for the Differential Diagnosis of Breast Nodules. [Journal Article]
- CONCLUSIONS: The RF model based on serum lipid biomarkers serves as a robust, noninvasive tool for assessing breast cancer risk, showing significant potential for clinical decision support in screening programs.
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- rs2357322 and rs17726078 Contribute to Breast Cancer Risk by Regulating DLX2 Expression. [Journal Article]
- CONCLUSIONS: rs2357322 and rs17726078 might influence DLX2 expression and further contribute to breast cancer risk.
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- Implementation and Audit of Mainstream Genetic Testing Within a High-Volume UK Breast Unit for Pathogenic Variations Associated With Breast Cancer Using the R208 and R444.1 National Test Directory Criterion. [Journal Article]Breast J. 2026; 2026(1):e2657384.BJ
- CONCLUSIONS: 14.3% of patients eligible and tested for a breast cancer-related hereditary P/LP variant were positive, which aligns with the expected number predicted by Genomics England. Family history scoring is an important element. Positive results were associated with changes in surgical decision-making for 14 women and enabled 3 patients to receive a PARP inhibitor.
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- Modified Nipple Correction Surgery Combined With Debridement for Refractory Nonpuerperal Mastitis: A Clinical Study. [Journal Article]Breast J. 2026; 2026(1):e8818284.BJ
- CONCLUSIONS: The fistula incision and debridement combined with modified nipple correction could treat refractory PCM effectively by facilitating the suture removal, reducing postoperative discomfort for patients, and making smaller surgical incisions possible. Consequently, this modified surgery has shown preliminary favorable results and warrants further investigation to determine generalizability.
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- Serum IL2Rα as a Diagnostic Biomarker and Its Functional Interplay With IL-2 in Breast Cancer. [Journal Article]
- CONCLUSIONS: Serum IL2Rɑ could serve as a complementary auxiliary diagnostic biomarker for breast cancer, with associations with systemic inflammation, immune cell infiltration, and aggressive disease. The functional antagonism between IL2RA and IL-2 highlights the IL-2/IL2RA axis as a critical regulator of breast cancer pathophysiology, supporting its potential as a therapeutic target for improving breast cancer diagnosis and treatment.
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- Pivotal Factors in Breast Cancer Molecular Subtypes Apoptosis Induction by ELF-EMF; Ki-67, ROS Level, HER-2, and SODs. [Journal Article]
- CONCLUSIONS: Taken together, our results confirmed that ELF-EMF induced ROS-dependent apoptosis, especially in HER-2-enriched breast cancer cells (the SKBR-3), in a p53-independent manner. Other molecular subtypes (MDA-MB-231 as TNBC, or MCF-7 as luminal A) showed resistance against the ROS level increasing and subsequent apoptosis induction by using antioxidant genes, especially SOD1.
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