- Optimizing safety and efficacy of asparaginase and blinatumomab therapy in frontline acute lymphoblastic leukemia regimens in diverse health care settings-international expert consensus. [Review]Cancer. 2026 Aug 15; 132(16):e70559.C
- Frontline blinatumomab combined with chemotherapy has resulted in improved outcomes in both pediatric and adult patients with acute lymphoblastic leukemia and is considered the new cornerstone of acute lymphoblastic leukemia treatment. The role of asparaginase in this new landscape of acute lymphoblastic leukemia treatment was extensively discussed by an expert panel of hemato-oncologists to reac…
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- How low do you need to go? Association between various prostate-specific antigen response measures and clinical outcomes in metastatic castration-sensitive prostate cancer in the Veterans Health Administration data. [Journal Article]Cancer. 2026 Aug 15; 132(16):e70494.C
- CONCLUSIONS: In a real-world mCSPC setting, achieving a PSA of <0.2 ng/mL (whether or not a PSA decline of 90% was reached) within 9 months of initiating ADT ± other treatments was associated with improved OS, which supports a PSA nadir of <0.2 ng/mL for optimizing mCSPC outcomes.
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- From screening to support: Structured bibliotherapy and community-based well-being programs as adjuncts to the Older Adults with Cancer-Depression Scale. [Letter]Cancer. 2026 Aug 15; 132(16):e70565.C
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- Relationship between bisphosphonate use and risks of recurrence and mortality among hormone receptor-positive and triple-negative breast cancer patients. [Journal Article]Cancer. 2026 Aug 15; 132(16):e70562.C
- CONCLUSIONS: Although this study confirmed the protective effects of post-diagnostic BP use on risks of mortality among HR+ cases, further studies are required to prove the effects of post-diagnostic BP use among TNBC participants.
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- DECIDER-2: Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy. [Randomized Controlled Trial]
- CONCLUSIONS: This trial investigates whether the in vitro cooperativity of DAC, VEN, and ATRA prolongs OS in unfit AML patients compared to placebo, offering a novel, low-toxicity triplet combination with a promising risk-benefit ratio.
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- Out-of-pocket costs are not the bottom line in financial toxicity. [Editorial]Cancer. 2026 Aug 15; 132(16):e70561.C
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- Radiomic phenotypes in nonmuscle-invasive bladder cancer: A precision biomarker guiding therapy. [Editorial]Cancer. 2026 Aug 15; 132(16):e70563.C
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- Sexual health behaviors and contraceptive practices among Canadian childhood, adolescent, and young adult cancer survivors and controls. [Journal Article]Cancer. 2026 Aug 15; 132(16):e70560.C
- CONCLUSIONS: CAYA cancer survivors demonstrate less sexual activity and condom use than controls. Higher treatment intensity is associated with less birth control use, suggesting potential misaligned fertility perceptions. Survivorship programs should integrate structured sexual health counselling.
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- Assessment of safe chemotherapy handling behaviors among oncology nurses in a conflict-affected setting: A cross-sectional study from Gaza. [Journal Article]Cancer. 2026 Aug 15; 132(16):e70550.C
- CONCLUSIONS: Although nurses demonstrated moderate to good compliance with chemotherapy safety protocols, critical gaps remain, particularly in drug administration and disposal practices. Regular targeted training, protocol reinforcement, and hiring of specialized oncology nurses are urgently needed.
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- Precision oncology meets Generative AI: assessing large language models in multidisciplinary GIST tumor boards. [Journal Article]
- CONCLUSIONS: Both models demonstrated high agreement with expert GIST MTB recommendations, with no significant performance difference between them. Diagnostic reasoning represented the weakest domain, reflecting the challenge of reconstructing context-dependent workup decisions from tumor board documentation. These findings support a potential assistive role for LLMs in GIST MTB workflows, while underscoring the continued necessity of expert oversight.
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- Converging engineered models of cancer and artificial intelligence. [Journal Article]
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