- Lifestyle and metabolic determinants of early- and late-onset colorectal cancer: insights from a tertiary medical center in Alabama. [Journal Article]
- CONCLUSIONS: Obesity was more prevalent in EOCRC patients and hence these differences should be considered in development of age-stratified screening and prevention strategies.
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- Early and late-onset colorectal cancers: a case-case comparison of risk factors. [Journal Article]
- CONCLUSIONS: Alcohol consumption, consuming the most alcohol in one's teens/twenties, binge drinking, having Lynch syndrome, and pre-diagnostic CRC symptoms were more associated with EOCRC than LOCRC.
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- The role of rurality and area-level disadvantage in lifestyle risk factors and psychological well-being among cancer survivors: findings from the 2021 NCI HINTS-SEER. [Journal Article]
- CONCLUSIONS: Area-level disadvantage was a contributor to rural cancer survivors' psychological well-being. Individual socioeconomic status remains the dominant determinant of lifestyle and mental health outcomes. Cancer survivors residing in socioeconomically disadvantaged rural areas may benefit from targeted mental health intervention. Future longitudinal research incorporating census tract-level geographic measures and residential histories is needed to clarify the mechanisms linking the geographic and socioeconomic context to survivorship outcomes.
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- Epidemiological landscape and clinical heterogeneity of primary pancreatic lymphoma: a population-based study. [Journal Article]
- CONCLUSIONS: PPL is an extremely rare malignancy, yet its incidence has increased steadily over the past four decades. The constructed nomograms can accurately predict 1-, 5-, and 10-year OS and DSS in PPL patients and effectively stratify patients into high-risk and low-risk groups, thus facilitating clinical decision-making.
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- Survivability in patients with rare sigmoid colon adenocarcinoma variants: exploring the influence of rural-urban continuum codes and social determinants of health in the USA. [Journal Article]
- CONCLUSIONS: Survival outcomes were significantly influenced by both place of residence and socioeconomic status, with the highest survival observed among patients with higher MHI in RUCC 2 and the poorest outcomes among low-income patients in RUCC 4. These results highlight the compounded impact of rurality and socioeconomic disadvantage, underscoring the need for targeted interventions-including strengthened oncology infrastructure, and reduced structural barriers.
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- Exercise trajectories and current exercise and risk of breast cancer: a cohort study of 325,953 women who participated in BreastScreen Norway. [Journal Article]
- CONCLUSIONS: Engaging in high-level exercise throughout one's lifetime significantly reduces the risk of breast cancer. This study highlights the importance of maintaining or increasing physical activity levels throughout life to mitigate breast cancer risk.
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- Post-diagnosis physical activity in relation to mortality among gynecological cancer survivors. [Systematic Review]
- CONCLUSIONS: Higher levels of physical activity after a gynecological cancer diagnosis were associated with improved survival. The results suggest that physical activity may represent a modifiable lifestyle factor with the potential to improve long-term outcomes among gynecological cancer survivors.
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- Construction and validation of a folate metabolism-related gene signature for prognosis prediction, immune landscape characterization, and molecular subtyping in glioma. [Journal Article]
- CONCLUSIONS: This study establishes a novel folate metabolism-related signature that reliably predicts prognosis, delineates immune landscape heterogeneity, and identifies potential therapeutic susceptibilities in glioma. The findings provide important insights into folate-associated tumor biology and offer a framework for risk stratification and personalized therapy.
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- Testing behavioral economics principles in mailed FIT outreach: a randomized trial. [Randomized Controlled Trial]
- CONCLUSIONS: The FIT test screening rate in the enhanced communication group was not statistically different from the original communication group. Using evidence-based behavioral economics principles in mailed FIT communications did not markedly improve the rate of CRC screening, but mailed FIT remains a key, cost-effective tool for reaching unscreened individuals.
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- Social determinants as pathways in disparities in oral cavity cancer stage at diagnosis: a registry-based analysis from 2010-2020. [Journal Article]
- CONCLUSIONS: Insurance status and neighborhood-level social factors may partially account for the differences in OCC stage at diagnosis between racial and ethnic groups. Identifying these pathways may help clarify and reduce these disparities.
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- Racial and ethnic disparities in receipt of guideline-concordant treatment for early-stage non-small cell lung cancer. [Journal Article]
- CONCLUSIONS: Addressing disparities in GCT for patients diagnosed with early-stage NSCLC is critical to improving survival outcomes. Future studies identifying factors influencing a patient's and physician's decision to receive, recommend, and adhere to GCT guidelines are needed to understand the complexity of treatment decision-making.
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- Racial and ethnic disparities in esophageal cancer survival are greatest at curable stages: a population-based study. [Journal Article]
- CONCLUSIONS: Survival disparities were most pronounced at curable stages, indicating inequities in post-diagnosis management. Lower treatment receipt and persistent survival differences after clinical adjustment suggest that structural and systemic factors contribute. These findings highlight a critical target for cancer control and underscore the need for system-level reforms to ensure equitable, stage-appropriate care.
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- Community-level contextual factors associated with lung cancer: a hot spot analysis. [Journal Article]
- CONCLUSIONS: This study found that the prevalence of lung cancer across communities can be explained, in part, by levels of environmental emissions, selected health, demographics and socioeconomic indicators.
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- Advances and challenges in CAR-T cell therapy for breast cancer: from molecular design to clinical application. [Review]
- Globally, breast cancer remains a leading cause of morbidity in women. Conventional therapies, including surgical intervention, radiation, and chemical treatments, though effective, frequently result in significant adverse effects and toxicity. CAR-T cell therapy represents a novel immunotherapeutic strategy, wherein T cells are genetically modified to precisely target and eradicate malignant cel…
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- Factors associated with cervical cancer screening in the South African demographic and health survey. [Journal Article]Cancer Causes Control. 2026 Jun 30; 37(7).CC
- CONCLUSIONS: Pap smear uptake remains suboptimal, particularly among Black women. There is a need for enhanced awareness and education initiatives as well as novel strategies involving community-based screening programs to encourage the uptake of cervical screening.
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