- Time to treatment initiation for breast cancer: A systematic review and meta-analysis of studies from 21 countries. [Review]Cancer Epidemiol. 2026 Oct 30; 105:103259. [Online ahead of print]CE
- CONCLUSIONS: Delays between diagnosis and treatment initiation are common, with more than one-third of patients waiting over 30 days. The pooled estimate reflects mainly high-income settings. Delays are longer, and very long delays more frequent, in low- and middle-income countries, where evidence remains sparse. Agreed TTI benchmarks, stronger oncology services, and more primary studies from low- and middle-income countries are priorities to close the cancer care gap.
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- Evaluation of disparities in colorectal cancer outcomes with increasing age: A national population-based study. [Journal Article]Cancer Epidemiol. 2026 Oct 27; 105:103262. [Online ahead of print]CE
- CONCLUSIONS: In contrast to non-oncological literature, we did not observe widening racial/ethnic disparities with age. Largest disparities were found in younger age groups suggesting differences in tumor biology may play a more important factor for cancer outcomes.
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- A policy evaluation of Australia's commercial solarium ban: A 14-year regression discontinuity analysis of melanoma incidence, mortality and clinical severity. [Journal Article]Cancer Epidemiol. 2026 Oct 27; 105:103265. [Online ahead of print]CE
- CONCLUSIONS: The ban was not associated with an abrupt nationwide reduction in melanoma incidence or mortality but coincided with improvements in selected demographic, geographic, and tumour-thickness groups. These heterogeneous patterns suggest a potential gradual policy effect rather than an immediate population-wide decline.
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- Metabolic syndrome, insulin resistance, a fatty-liver proxy, inflammation, and apolipoproteins in relation to breast cancer risk in young Korean women: A prospective cohort study. [Journal Article]Cancer Epidemiol. 2026 Oct 27; 105:103266. [Online ahead of print]CE
- CONCLUSIONS: Metabolic and apolipoprotein markers were not associated with breast cancer risk in this predominantly premenopausal Korean cohort. These sequelae therefore do not appear to share the inverse association adiposity shows before menopause. These are, to our knowledge, the first prospective apolipoprotein data on premenopausal breast cancer risk in East Asian women.
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- Comment on "Regional and statewide hysterectomy-corrected endometrial cancer incidence and five-year relative survival in Texas". [Letter]Cancer Epidemiol. 2026 Oct 24; 105:103263. [Online ahead of print]CE
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- Head and neck cancer incidence and two-year mortality in Aotearoa New Zealand, 2009-2020: a national population-based cohort study. [Journal Article]Cancer Epidemiol. 2026 Oct 23; 105:103264. [Online ahead of print]CE
- CONCLUSIONS: These findings indicate an OPC-driven shift in HNC epidemiology in AoNZ and a persistent inequitable burden of both disease occurrence and early mortality, supporting stronger surveillance and equity-focused cancer-control responses.
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- Monthly high-dose cholecalciferol supplementation in prostate cancer patients (ProsD trial): A nested analysis of vitamin D metabolites, metabolic ratios, and biochemical safety. [Journal Article]Cancer Epidemiol. 2026 Oct 22; 105:103258. [Online ahead of print]CE
- CONCLUSIONS: Monthly oral supplementation of 50,000 IU cholecalciferol in men with prostate cancer produced sustained increases across multiple vitamin D metabolites over 24 months, accompanied by adaptive shifts in metabolite ratios consistent with regulated catabolic activation, with no clinically meaningful abnormalities in biochemical markers.
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- Temporal evolution of gastric adenocarcinoma in the United States, 2000-2023: Incidence, presentation, registry-recorded treatment, and survival. [Journal Article]Cancer Epidemiol. 2026 Oct 20; 105:103256. [Online ahead of print]CE
- CONCLUSIONS: Distant-stage presentation became more frequent while recorded surgery declined and short-term survival improved modestly. Within-stage changes represented most of the surgery decline. Additional registry years are needed to assess persistence of the post-2019 incidence increase.
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- Beyond the pleura: National trends in mesothelioma mortality by anatomical site in Spain, 1999-2024. [Journal Article]Cancer Epidemiol. 2026 Oct 17; 105:103260. [Online ahead of print]CE
- CONCLUSIONS: Absolute mesothelioma deaths increased in Spain while age-standardised rates attenuated after 2016. The continued increase in recorded peritoneal mortality and the substantial contribution of unspecified-site deaths indicate that surveillance should not rely solely on pleural mesothelioma, highlighting the need for comprehensive monitoring of the complete ICD-10 C45 category and improved anatomical classification.
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- Hepatocellular carcinoma in Turkey: A nationwide health system database analysis of clinical patterns and survival. [Journal Article]Cancer Epidemiol. 2026 Oct 16; 105:103255. [Online ahead of print]CE
- CONCLUSIONS: In this nationwide analysis, HCC in Turkey was characterised by limited OS and pronounced sex-based disparities, with survival differing by cirrhosis status and recorded etiology; etiologic ascertainment was itself survival-dependent, so these contrasts describe recorded categories. Hepatitis B was the most frequently recorded specific etiology, underscoring the continued importance of HBV prevention, screening, and surveillance, while HCV, HDV, alcohol-related and metabolic liver disease accounted for smaller recorded proportions; temporal trends in etiology were not analysed. Because tumour stage and liver function were unavailable, the treatment-survival associations are descriptive and subject to confounding by indication. Efforts focused on HBV control, earlier detection, risk-based surveillance of patients with cirrhosis, and improved referral pathways may improve population-level outcomes.
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- Comparing the five-year relative survival trends of cervical cancer in Puerto Rico and the United States (2000-2021): A joinpoint analysis. [Journal Article]Cancer Epidemiol. 2026 Oct 14; 105:103251. [Online ahead of print]CE
- CONCLUSIONS: Puerto Rico shows poorer cervical cancer five-year RS than the US. Increased five-year RS was observed in the US overall population after 2013. In Puerto Rico, improvements in five-year RS were observed after 2011, but these were halted after 2016. This finding may suggest that barriers to accessing care during periods of extreme events, such as the convergence of the 2017 hurricanes and the 2020 COVID-19 pandemic challenges, likely affected survival trends from 2016 to 2021. Future research should further characterize barriers to improve cervical cancer survival.
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- Cancer incidence trends among young adults in Portugal, 2001-2022: A population-based study. [Journal Article]Cancer Epidemiol. 2026 Oct 13; 105:103250. [Online ahead of print]CE
- CONCLUSIONS: Cancer incidence among young Portuguese adults is increasing, particularly among women, with sex-specific and site-specific patterns. While declines in tobacco-related cancers reflect successful prevention efforts, rising rates of breast, colorectal, thyroid, and melanoma in young adults signal the need for enhanced targeted prevention strategies and continued etiological research.
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- Is the standardized incidence ratio of second primary cancers robust to index-cancer survival gains? A simulation and SEER-based evaluation. [Journal Article]Cancer Epidemiol. 2026 Oct 13; 105:103252. [Online ahead of print]CE
- CONCLUSIONS: Survivor-recomposition bias in the SPC SIR exists in principle but was small on average in the sites and calendar period studied. Unlike cumulative incidence, the SIR can generally be interpreted across calendar eras without major survival correction, although weak, site-specific, or longer-term effects cannot be excluded.
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- The prevalence of cardiac dysfunction among breast cancer survivors: a systematic review and meta-analysis. [Review]Cancer Epidemiol. 2026 Oct 13; 105:103253. [Online ahead of print]CE
- CONCLUSIONS: Prevalence of cardiac dysfunction appears to be higher among long-term breast cancer survivors compared to the general population.
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- Risk of malignant melanoma in hyperthyroid and hypothyroid female populations: Results from a large Danish cohort study. [Journal Article]Cancer Epidemiol. 2026 Oct 12; 105:103254. [Online ahead of print]CE
- CONCLUSIONS: Our findings do not provide clear evidence of an association between thyroid dysfunction and the rate of MM in women. The observed decreased rate of superficial spreading MM among women with hypothyroidism within 10 years of diagnosis should be interpreted cautiously, as it was the only statistically significant finding among multiple subgroup analyses and may represent a chance finding. Further studies incorporating detailed clinical and biochemical measures of thyroid function are warranted.
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