- Siwuyin Inhibits Esophageal Cancer Metastasis by Modulating PHD 2/3-HIF1α Signal Pathway Mediated by Fumaric Acid. [Journal Article]
- CONCLUSIONS: Fumarate accumulation promotes esophageal squamous cell carcinoma (ESCC) metastasis, and SWY could inhibit ESCC cell metastasis by regulating the fumarate accumulation-mediated PHD2/3-HIF1α signaling pathway.
- Publisher Full Text (DOI)
- Ziyin Huatan Recipe Inhibits Lymph Node Metastasis in Gastric Cancer via Downregulating PLAG1-Mediated VEGF-C/VEGFR-3 Signaling. [Journal Article]
- CONCLUSIONS: ZYHT is an effective compound for inhibiting lymph node metastasis in GC via downregulation of PLAG1-mediated VEGF-C/VEGFR-3 signaling. Additionally, PLAG1 may serve as a significant biomarker during the process of GC metastasis through regulating VEGF-C/VEGFR-3 pathway.
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- Maxing Shigan Decoction Regulates Immune Inflammatory Response of Adenovirus Pneumonia by Inhibiting cGAS-STING Pathway. [Journal Article]
- CONCLUSIONS: MSD modulated the immune inflammatory response in AVP by inhibiting the cGAS-STING pathway. It protected lung tissue from damage caused by excessive immune responses and inflammatory reactions.
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- Efficacy and Safety of Acupuncture Combined with Hydroxychloroquine in Treating Primary Sjögren's Syndrome: A Randomized Controlled Trial. [Journal Article]
- CONCLUSIONS: Acupuncture combined with HCQ treatment is more effective than HCQ alone in improving dry mouth and dry eye symptoms in pSS patients, with a good safety profile. Additionally, acupuncture treatment may indirectly alleviate anxiety and depression symptoms by improving clinical outcomes such as dry mouth and dry eye. (Registration No. TCTR20230116003).
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- Compound Kushen Injection Alleviates Experimental Colitis in Mice by Regulating Macrophage Polarization through TLR4/NF-κB Signaling. [Journal Article]
- CONCLUSIONS: CKI alleviates experimental colitis in mice by modulating macrophage polarization, reducing inflammatory responses, and repairing the intestinal barrier; this effect may closely associated with inhibition of TLR4/NF-κB signaling pathway.
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- Liangfu Pill Alleviates Constipation-Predominant Irritable Bowel Syndrome through Modulation of 5-HT Signaling Pathway and Gut Microbiota. [Journal Article]
- CONCLUSIONS: LFP alleviates IBS-C symptoms, improves overall condition and especially reduces visceral sensitivity in rats. The potential mechanism may involve modulation of 5-HT signaling pathway and gut microbiota.
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- Berberine Suppresses Inflammatory Response in Severe Pneumonia by Specifically Targeting Upregulation of SIRT1 to Activate Nrf2 Signaling Pathway. [Journal Article]
- CONCLUSIONS: BER promoted the viability and proliferation of KP-treated RLE-6TN cells, inhibited cell apoptosis and inflammatory responses, and alleviated severe pneumonia through the SIRT1/Nrf2 signaling pathway activation.
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- Complex Intervention Frameworks for Acupuncture: Recommendations from a Scoping Review. [Journal Article]
- CONCLUSIONS: Existing frameworks vary substantially in phase structures and are not fully adapted to acupuncture. Potential considerations in future framework development include acupuncture theory and clinical experience, individualized intervention protocol, practitioner factors, acupuncture-specific outcomes, long-term follow-up and safety, and biomedical outcomes.
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- Efficacy, Safety, and Pharmacoeconomic Evaluation of Shiwei Longdanhua Capsules in Acute Exacerbation of Chronic Bronchitis with Phlegm-Heat Obstructing Fei (Lung): A Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Control Trial. [Journal Article]
- CONCLUSIONS: SWLDH significantly improved CM symptoms, accelerated cough resolution, and enhanced quality of life in AECB patients with PHOF syndrome, with a favorable safety profile and cost-effectiveness. (Trial registration No. ChiCTR2200066665).
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- Impact of Shexiang Baoxin Pill (MUSKARDIA) on Cardiovascular Outcomes by Baseline Hemoglobin Levels in 2,494 Patients with Chronic Stable Coronary Artery Disease: A Secondary Subgroup Analysis. [Journal Article]
- CONCLUSIONS: MUSKARDIA demonstrated significant cardiovascular protective effects in CAD patients with Hb < 140 g/L, particularly reducing non-fatal MI risk, while showing limited efficacy in patients with Hb>140 g/L. This highlights its cardiovascular protective role in high-risk populations characterized by greater ischemic risk and inadequate myocardial oxygen supply.
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- Zhangyanming Tablets for Dry Eye Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study. [Journal Article]
- CONCLUSIONS: ZYMT combined with 0.1% sodium hyaluronate eye drops can significantly alleviate the ocular symptoms, improve tear film, and demonstrate a good safety. (Registration No. ChiCTR2200061479).
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