- Major adverse nutritional events (MANE): A composite outcome linking body composition and postoperative risk in colorectal cancer surgery. [Journal Article]Clin Nutr. 2026 Oct 14; 67:106821. [Online ahead of print]CN
- CONCLUSIONS: MANE identified distinct sex-specific patterns of morphofunctional vulnerability, highlighting the relevance of tissue quality and distribution beyond muscle quantity alone. MANE may provide a clinically oriented framework for evaluating morphofunctional markers and developing sex-specific thresholds based on early clinical outcomes. External validation is required.
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- Zinc supplementation counteracts the age-related impairment of interferon-α response by reconstituting basal interferon Regulatory factor 3 levels. [Journal Article]Clin Nutr. 2026 Oct 10; 67:106818. [Online ahead of print]CN
- CONCLUSIONS: The findings indicate that the reduced IFN-α response is not an inevitable part of aging. By reducing the basal availability of IRF3, zinc deficiency builds a molecular barrier that limits the cellular capacity for IFN-α production. However, short-term zinc supplementation can counteract this limitation. Hence, routine assessment and correction of zinc status should be integrated into geriatric care to enhance immune resilience in the aging population.
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- Biological aging or dietary biomarkers? Interpreting associations between dietary patterns and biological age acceleration. [Letter]Clin Nutr. 2026 Oct 16; 67:106823. [Online ahead of print]CN
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- Prospective associations between empirical dietary inflammatory pattern score and cardiovascular diseases and cancer. [Journal Article]Clin Nutr. 2026 Oct 08; 67:106817. [Online ahead of print]CN
- CONCLUSIONS: Dietary patterns with a higher proinflammatory potential were associated with higher stroke risk, particularly among smokers. These findings suggest that reducing the inflammatory potential of the diet may be a promising strategy for prevention of CVDs.
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- Circulating biomarkers of oxidative stress and antioxidant status in women with overweight and obesity following an 8-week energy-restricted ketogenic diet: Results from the randomized KETO-MINOX study. [Journal Article]Clin Nutr. 2026 Oct 09; 67:106816. [Online ahead of print]CN
- CONCLUSIONS: Sixty-six participants were included in the final analyses (KETO, n = 32; STD, n = 34). Both interventions induced significant changes in several redox-related biomarkers, with a marked rise in antioxidant capacity accompanied by a rise in 8-OHdG, and a net reduction in the composite OSI. No between-group difference survived correction for multiple testing at either time point; the early differences in ACW, PCL and total protein at week 4 were nominal only. Within-arm trajectories of FGF21 and GDF15 differed, but the randomised between-diet contrasts for both markers were non-significant. Principal component analysis revealed no distinct ketogenic redox phenotype. An eight-week energy-restricted KD did not provide detectable additional benefits for systemic redox homeostasis compared with a standard energy-restricted diet. The increase in antioxidant capacity was proportional to the degree of weight loss, whereas the OSI was not, indicating an absence of a KD-specific effect rather than establishing weight loss as the determinant of redox adaptation overall. The findings suggest that changes related to energy restriction and weight loss may be more important determinants of the observed redox adaptations than nutritional ketosis per se in women with overweight and obesity.
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- Nutrition education in medical schools: From the ESPEN NEMS position paper to a practical teaching tool. [Journal Article]Clin Nutr. 2026 Oct 05; 66:106810. [Online ahead of print]CN
- CONCLUSIONS: The pragmatic approach of the NEMS project and the development of standardized teaching materials could support the widespread integration of nutrition into medical curricula across Europe.
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- Lysine degradation-related metabolic remodeling in sarcopenia: Mendelian randomization prioritization and multi-omics-based characterization. [Journal Article]Clin Nutr. 2026 Oct 07; 66:106815. [Online ahead of print]CN
- CONCLUSIONS: Lysine degradation was prioritized as an ALM-related metabolic pathway through exploratory MR-based pathway analysis. Multi-omics characterization indicated heterogeneous and compartment-specific remodeling rather than uniform alteration of the entire pathway, with the most coherent cross-omics pattern involving trimethyllysine-derived carnitine metabolism. These findings support lysine-related metabolism as a candidate metabolic framework for sarcopenia while warranting further mechanistic and longitudinal validation.
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- A 12-week randomized controlled trial of the dietary approaches to stop hypertension (DASH) diet in seropositive rheumatoid arthritis: Effects on disease activity and outcomes. [Journal Article]Clin Nutr. 2026 Oct 01; 66:106811. [Online ahead of print]CN
- CONCLUSIONS: A 12-week DASH dietary intervention may provide clinically meaningful improvements in disease activity and patient-reported outcomes in patients with seropositive RA. These findings support the potential role of the DASH dietary pattern as a promising dietary approach to complement the management of RA. However, the relatively high attrition rate should be considered when interpreting the findings.
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- Reply to the letter to the editor: 'comment on "synergistic effects of partial enteral nutrition combined with ustekinumab in Crohn's disease"'. [Letter]Clin Nutr. 2026 Sep 26; 66:106807. [Online ahead of print]CN
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- Using ultra-processed food evidence at the right level of resolution in clinical dietetic practice. [Journal Article]Clin Nutr. 2026 Sep 30; 66:106813. [Online ahead of print]CN
- Ultra-processed food (UPF) consumption, captured by the Nova classification, is robustly associated with adverse health outcomes when considered at the level of the overall diet, and this evidence increasingly informs dietary guidance. Translating this evidence into advice about individual foods is far less straightforward. Nova classifies foods by the degree and purpose of industrial processing …
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- Dietary patterns and adverse pregnancy outcomes: Complementary insights from a priori and a posteriori approaches in a prospective cohort. [Journal Article]Clin Nutr. 2026 Oct 05; 66:106812. [Online ahead of print]CN
- CONCLUSIONS: An empirically derived dietary profile characterized by vegetables, tubers, legumes, and dairy intake, was associated with lower GWG and higher birth weight. The limited agreement between approaches highlights that a priori indices and data-driven methods capture complementary dimensions of diet, supporting their combined use.
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- Comment on "Synergistic effects of partial enteral nutrition combined with ustekinumab in Crohn's disease". [Letter]Clin Nutr. 2026 Sep 18; 66:106793. [Online ahead of print]CN
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- Reply- Letter to the Editor- "comments on: Effects of early postoperative synbiotic supplementation on gastrointestinal outcomes after sleeve gastrectomy: A randomized controlled trial". [Letter]Clin Nutr. 2026 Sep 29; 66:106808. [Online ahead of print]CN
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- Early neonatal lipid intake is associated with verbal comprehension and supramarginal gyrus volume at school age in very low birth weight preterm infants: A longitudinal cohort study. [Journal Article]Clin Nutr. 2026 Sep 22; 66:106797. [Online ahead of print]CN
- CONCLUSIONS: Higher lipid intake during the first week of life was associated with better verbal comprehension and larger supramarginal gyrus volume at school age in VLBW preterm infants, whereas protein intake was associated with the volume of several language-related cortical regions. Given the observational design and the attenuation of the association with verbal comprehension after adjustment for CRIB II score, these findings should be interpreted as associations rather than evidence of causality.
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- Recovery of oral NUTRItion after PANCreatic surgery (NUTRIPANC): Results from a prospective cohort study. [Journal Article]Clin Nutr. 2026 Sep 21; 66:106796. [Online ahead of print]CN
- CONCLUSIONS: After pancreatic resection, fewer than one-third of patients achieved the recommended energy and protein target within the first week. Failure to achieve the caloric target was not independently associated with worse short-term outcomes, supporting a selective rather than routine use of early medical nutrition therapy.
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