- Comparison of Sevoflurane and Propofol-Fentanyl for Laryngeal Mask Airway Insertion in Pediatric cases. [Randomized Controlled Trial]Clin Ter. 2026 Nov-Dec; 177(6):1731-1735.CT
- CONCLUSIONS: Propofol-fentanyl provides faster induction and LMA insertion, whereas sevoflurane offers superior hemodynamic stability with comparable safety profiles in pediatric patients.
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- Occupational sun exposure and dry maculopathy and/or cataract in two Italian coastal populations with high solar irradiance: a 2026 comparative observational study between Ischia and the coastal areas south of Livorno. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1727-1730.CT
- CONCLUSIONS: The findings suggest a high prevalence of early lens changes among workers occupationally exposed to prolonged solar radiation in marine environments. Although no difference emerged between the two study populations, the results support the need for preventive occupational eye health measures and further longitudinal investigations.
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- Anatomical Variations of the Ansa Cervicalis: A Systematic Review and Meta-analysis of Cadaveric Studies. [Systematic Review]Clin Ter. 2026 Nov-Dec; 177(6):1714-1726.CT
- CONCLUSIONS: The ansa cervicalis demonstrates substantial anatomical variability, despite its near-universal presence. Awareness of these variations is essential for safe surgical navigation during neck dissection, carotid procedures, and laryngeal reinnervation.
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- From Dysbiosis to Malignancy: The Female Genital Tract Microbiome in Endometrial Cancer; Insights from a Systematic Review and Meta-Analysis. [Systematic Review]Clin Ter. 2026 Nov-Dec; 177(6):1698-1713.CT
- CONCLUSIONS: Female genital tract microbial dysbiosis is associated with EC, characterized particularly by depletion of potentially protective microorganisms and enrichment of potentially pathogenic or infection-associated taxa. These microbial alterations may have potential as adjunctive biomarkers for EC risk stratification and early detection. However, the available observational evidence does not establish a causal role of microbial dysbiosis or infection in endometrial carcinogenesis. Large prospective studies using standardized sampling, sequencing, and analytical methods are required to clarify causality and determine the clinical utility of microbiome-based diagnostic and therapeutic approaches.
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- Effectiveness of Quality Improvement Strategies in Preventing Healthcare-Associated Infections Among Neurosurgical Patients Admitted to Intensive Care Units: A Systematic Review. [Systematic Review]Clin Ter. 2026 Nov-Dec; 177(6):1685-1697.CT
- CONCLUSIONS: Structured QI interventions, particularly EVD-specific care bundles, device-associated infection prevention protocols, and staff education programs with compliance monitoring, consistently reduce HAI incidence in neurosurgical and neurological ICU settings. Although the evidence base is predominantly non-randomized, findings are directionally consistent across diverse healthcare systems and institutional contexts. Universal adoption of evidence-based infection prevention frameworks in neurocritical care is strongly supported.
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- Albuminuria as a Clinical Marker of Subclinical Myocardial Dysfunction in Diabetes: A Systematic Review and Meta-analysis. [Systematic Review]Clin Ter. 2026 Nov-Dec; 177(6):1671-1684.CT
- CONCLUSIONS: Albuminuria identifies patients with diabetes who have greater subclinical systolic and diastolic myocardial impairment despite preserved ejection fraction. Urinary albumin-to-creatinine ratio may help identify asymptomatic patients who could benefit from deformation imaging, although prospective validation is required.
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- Artificial Intelligence in Breast Cancer Diagnosis, Treatment, and Perioperative Management: A Systematic Review of Current Applications and Future Perspectives. [Systematic Review]Clin Ter. 2026 Nov-Dec; 177(6):1656-1670.CT
- CONCLUSIONS: Artificial intelligence demonstrated clinically meaningful performance across the five domains with eligible primary studies. Breast cancer-specific perioperative and intensive care primary studies were absent, representing the largest evidence gap. External validation, demographic diversity, and prospective clinical integration evidence remained the most consistently identified limitations. Prediction of molecular receptor status without immunohistochemistry requires rigorous prospective safety validation before it can complement standard testing.
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- Medicinal plants vs metronidazole in bacterial vaginosis: a narrative review of evidence from randomized clinical trials. [Review]Clin Ter. 2026 Nov-Dec; 177(6):1643-1655.CT
- CONCLUSIONS: Medicinal plants appear to be safe and effective alternatives or adjuncts for bacterial vaginosis; however, the heterogeneity in study designs and short follow-up periods limits definitive conclusions. Further well-designed, multicenter randomized trials with standardized protocols and long-term follow-up, along with studies exploring individual plants and their mechanisms of action, are needed to confirm efficacy, safety, and reproducibility and to support evidence-based use.
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- Outcomes of a Multidisciplinary Endovascular Aortic Program at the Vietnam National Heart Institute: A Single-Center Observational Study of TEVAR, EVAR, and Registry Data. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1633-1642.CT
- CONCLUSIONS: A structured multidisciplinary endovascular aortic program at VNHI was associated with high technical success and favorable mid-term outcomes in selected patients undergoing TEVAR or EVAR. These findings support the feasibility of organized aortic care in an emerging healthcare system; however, prospective risk-adjusted evaluation is required to determine the independent effect of the program on clinical outcomes. Complete patient-level reconciliation and standardized longitudinal surveillance are necessary for robust benchmarking.
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- Impact of BCL3 Expression and Clinical-Hematologic Risk Factors on Early Molecular Response, Reticulin Fibrosis, and Survival Outcomes in Chronic Myeloid Leukemia: A Prognostic Cohort Study. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1618-1632.CT
- CONCLUSIONS: Higher baseline BCL3 expression is a prognostic factor associated with treatment failure in TKI-treated chronic-phase CML in this cohort. The 1.60 threshold is exploratory and internally derived; external validation is required before BCL3 can be used for risk stratification or treatment decisions.
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- Are Mid-Level Health Providers Prepared for Diabetic Peripheral Neuropathy Screening? - A cross-sectional study from South India. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1606-1617.CT
- CONCLUSIONS: The study showed a moderate level of knowledge regarding DPN. Nearly half of the participants never screened for DPN routinely, which is driven largely by insufficient in-service training and a critical shortage of screening equipment. Integrating structured DPN training into their education curriculum and ensuring the availability of equipment at the centres represent high-priority policy interventions to reduce the burden of preventable diabetic complications.
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- Public Awareness, Attitudes, and Knowledge of Materials Used in Body Filler Injections: A Cross-Sectional Study. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1593-1605.CT
- CONCLUSIONS: Our study demonstrated high general awareness of dermal fillers but identified important gaps in specific safety knowledge and pre-procedure counseling. Greater emphasis on evidence-based education, comprehensive informed consent, qualified healthcare providers, and reliable digital health information is needed to promote safer filler practices.
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- Clinical Utility of Doppler Ultrasonography in Preoperative Risk Stratification of Ovarian Masses: A Retrospective Multi-Centric Analysis. [Multicenter Study]Clin Ter. 2026 Nov-Dec; 177(6):1584-1592.CT
- CONCLUSIONS: The resistance index derived from Doppler ultrasonography represents a valuable and reliable parameter for preoperative characterization of ovarian masses. Its integration into routine imaging protocols may enhance early detection of malignancy and support more informed surgical decision-making.
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- Learning Curve in Thoracoscopic Mediastinal Mass Excision: A Multicenter Retrospective Cohort Study Using Cumulative Sum and Multivariable Regression Analysis. [Multicenter Study]Clin Ter. 2026 Nov-Dec; 177(6):1571-1583.CT
- CONCLUSIONS: VATS mediastinal mass excision is safe and feasible, with surgical proficiency achieved after approximately 20-26 cases. Operative time was the most reliable indicator of learning progression, and the learning effect persisted after multivariable adjustment for patient-, tumour- and country-related factors. Structured mentorship and careful case selection are recommended during the early learning phase.
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- Acute-phase HOMA2-IR and in-hospital cardiovascular complications in patients with acute coronary syndrome without known diabetes. [Journal Article]Clin Ter. 2026 Nov-Dec; 177(6):1564-1570.CT
- CONCLUSIONS: Acute-phase HOMA2-IR-defined insulin resistance was associated with cardiovascular complications during the index hospitalization, mainly heart-failure-related events. These findings are associational and require confirmation in multicenter cohorts.
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