- The Impact of Nodular Goiter on the Short-Term Efficacy of Radioactive Iodine Therapy for Differentiated Thyroid Carcinoma: A Propensity Score Matching Study. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 27. [Online ahead of print]CE
- CONCLUSIONS: After controlling for measured baseline confounding using PSM, concomitant NG was not an independent factor associated with short-term RAI therapy efficacy in patients with DTC. N1b stage and elevated pretreatment sTg were independently associated with poor short-term response.
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- Baseline Predictors of Incomplete Biochemical and Radiological Outcomes During Cabergoline Treatment of Prolactinomas: A Retrospective Cohort From a Tertiary Referral Center. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 26. [Online ahead of print]CE
- CONCLUSIONS: Using a composite operational definition of incomplete response to cabergoline, no routinely available baseline clinical, biochemical, or gross tumor burden variable was independently associated with the composite endpoint or with incomplete radiological response. Baseline prolactin was associated only with incomplete biochemical response, and discrimination remained limited. Conventional baseline variables appear insufficient for clinically useful prediction, highlighting the need for more comprehensive models incorporating dynamic treatment-related, imaging features of tumor invasiveness, and molecular markers.
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- Letter to the Editor in Response to Comment on "ACTH Stimulation Testing Is Often Unnecessary After Appropriate Patient Preparation Prior to Screening Cortisol Measurement" by Malik M. M. [Letter]Clin Endocrinol (Oxf). 2026 Oct 20. [Online ahead of print]CE
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- Endoscopic Ultrasound-Guided Ethanol Ablation for Benign Insulinoma: A Single-Centre Experience and Literature Review. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 14. [Online ahead of print]CE
- CONCLUSIONS: EUS-guided ethanol ablation is an effective and well-tolerated treatment for benign insulinoma. It represents a viable minimally invasive alternative to surgery and remains effective for managing recurrence or initial treatment failure without compromising subsequent surgical options.
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- LGALS3 Drives Dopamine Agonist Resistance in Prolactinoma by Activating the MAPK/ERK Pathway: A Multi-Omics Study. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 14. [Online ahead of print]CE
- CONCLUSIONS: LGALS3 functions as a candidate diagnostic biomarker and represents a promising therapeutic target. Targeting the LGALS3-MAPK axis presents a viable strategy to restore therapeutic sensitivity in patients with refractory prolactinoma.
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- Survival in Patients With Pituitary Carcinoma. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 13. [Online ahead of print]CE
- CONCLUSIONS: PC carries a poor prognosis, with a median survival of only 3 years. Improved survival was associated with temozolomide exposure, female sex, and nonfunctional tumour subtype and underscores the prognostic relevance of tumour biology and treatment approach.
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- Nailfold Capillaroscopy in Primary Hyperparathyroidism: Cautions Regarding Biomarker Claims and Methodology. [Letter]Clin Endocrinol (Oxf). 2026 Oct 13. [Online ahead of print]CE
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- Increased Risk of Thyrotoxicosis After COVID-19 in Adolescents and Young Adults During the Omicron-Predominant Period: A Nationwide Matched Study. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 11. [Online ahead of print]CE
- CONCLUSIONS: In this nationwide cohort, COVID-19 was associated with higher risks of database-recorded diagnoses of thyrotoxicosis and hypothyroidism than influenza during the Omicron-predominant period. The strongest association was observed for thyrotoxicosis diagnosis and ATD initiation in younger individuals, underscoring the importance of post-COVID-19 thyroid monitoring in adolescents and young adults.
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- Cortisol Cutoffs for Adrenal Insufficiency Using Elecsys II: A Systematic Review. [Review]Clin Endocrinol (Oxf). 2026 Oct 11. [Online ahead of print]CE
- CONCLUSIONS: We affirm recommendations to lower the cortisol threshold for AI when using monoclonal assays. A peak threshold of 405 nmol/L (14.7 µg/dL) is suggested for a standard-dose ACTH test on the Elecsys II assay for diagnosis of AI, acknowledging limitations related to the small number and GRADE quality of included studies.
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- Adrenal Infections: An Underrecognized Cause of Primary Adrenal Insufficiency. [Review]Clin Endocrinol (Oxf). 2026 Oct 09. [Online ahead of print]CE
- CONCLUSIONS: Early recognition is essential, as management requires two complementary approaches: 1. antimicrobial therapy directed at the causative pathogen, and 2. hormonal replacement in patients with established adrenal insufficiency and longitudinal hormonal surveillance in those with preserved adrenal reserve at initial presentation.
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- Multidisciplinary Care Model for Differences in Sex Development: An Implementation Research Study. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 09. [Online ahead of print]CE
- CONCLUSIONS: The MD-DSD care model was feasible and demonstrated favourable perceived sustainability, with improvement in the perceived quality of care reported by both parents and HCPs.
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- Cardiometabolic Protein Profile Changes During Gender-Affirming Hormone Therapy: A Prospective Clinical Study. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 08. [Online ahead of print]CE
- CONCLUSIONS: T- and E2-based GAHT were associated with opposite directional changes in cardiometabolic protein profiles.
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- Insulinoma With Secondary Adrenal Dysfunction: Clinical Characteristics and High-Risk Factors. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 07. [Online ahead of print]CE
- CONCLUSIONS: Insulinoma patients with secondary adrenal dysfunction have a higher risk of severe hypoglycemia. Our study suggest a potential correlation between tumour size and secondary adrenal dysfunction in insulinoma patients which may increase perioperative risks. Routine screening for adrenal cortical function is recommended to prevent the occurrence of more serious complications.
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- Congenital Adrenal Hyperplasia due to Proximal Steroidogenic Defects: A Single-Centre Experience From New Delhi. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 07. [Online ahead of print]CE
- CONCLUSIONS: The present study highlights the wide phenotypic spectrum associated with STAR and CYP11A1 variants, ranging from classical neonatal salt-wasting crisis with 46,XY sex reversal, to isolated primary adrenal insufficiency, or isolated undervirilisation, with later emergence of gluco- and mineralocorticoid deficiency.
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- Testosterone Replacement Therapy in Adolescents and Young Adults With Prader-Willi Syndrome: Efficacy and Effects on Behaviour. [Journal Article]Clin Endocrinol (Oxf). 2026 Oct 06. [Online ahead of print]CE
- CONCLUSIONS: Under close surveillance, TRT is an efficacious method to maintain BMD and improve body composition in hypogonadal male patients with PWS, with minor effects on behaviour in most cases.
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