(Clinical nutrition[TA])
7,567 results
  • Circulating biomarkers of oxidative stress and antioxidant status in women with overweight and obesity following an 8-week energy-restricted ketogenic diet: Results from the randomized KETO-MINOX study. [Journal Article]
    Clin Nutr. 2026 Oct 09; 67:106816. [Online ahead of print]Drabińska-Fois N, Bauer W, … Romaszko JCN
  • CONCLUSIONS: Sixty-six participants were included in the final analyses (KETO, n = 32; STD, n = 34). Both interventions induced significant changes in several redox-related biomarkers, with a marked rise in antioxidant capacity accompanied by a rise in 8-OHdG, and a net reduction in the composite OSI. No between-group difference survived correction for multiple testing at either time point; the early differences in ACW, PCL and total protein at week 4 were nominal only. Within-arm trajectories of FGF21 and GDF15 differed, but the randomised between-diet contrasts for both markers were non-significant. Principal component analysis revealed no distinct ketogenic redox phenotype. An eight-week energy-restricted KD did not provide detectable additional benefits for systemic redox homeostasis compared with a standard energy-restricted diet. The increase in antioxidant capacity was proportional to the degree of weight loss, whereas the OSI was not, indicating an absence of a KD-specific effect rather than establishing weight loss as the determinant of redox adaptation overall. The findings suggest that changes related to energy restriction and weight loss may be more important determinants of the observed redox adaptations than nutritional ketosis per se in women with overweight and obesity.
  • Lysine degradation-related metabolic remodeling in sarcopenia: Mendelian randomization prioritization and multi-omics-based characterization. [Journal Article]
    Clin Nutr. 2026 Oct 07; 66:106815. [Online ahead of print]Hong SW, Park JS, Kang JHCN
  • CONCLUSIONS: Lysine degradation was prioritized as an ALM-related metabolic pathway through exploratory MR-based pathway analysis. Multi-omics characterization indicated heterogeneous and compartment-specific remodeling rather than uniform alteration of the entire pathway, with the most coherent cross-omics pattern involving trimethyllysine-derived carnitine metabolism. These findings support lysine-related metabolism as a candidate metabolic framework for sarcopenia while warranting further mechanistic and longitudinal validation.
  • Using ultra-processed food evidence at the right level of resolution in clinical dietetic practice. [Journal Article]
    Clin Nutr. 2026 Sep 30; 66:106813. [Online ahead of print]Louie JCYCN
  • Ultra-processed food (UPF) consumption, captured by the Nova classification, is robustly associated with adverse health outcomes when considered at the level of the overall diet, and this evidence increasingly informs dietary guidance. Translating this evidence into advice about individual foods is far less straightforward. Nova classifies foods by the degree and purpose of industrial processing …