- Letter Regarding Surgical Approaches for the Management of Peripheral Ulcerative Keratitis With Corneal Perforation. [Letter]Cornea. 2026 Sep 17. [Online ahead of print]C
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- Pediatric Corneal Neurotization for Neurotrophic Keratopathy: A Systematic Review. [Journal Article]Cornea. 2026 Sep 21. [Online ahead of print]C
- CONCLUSIONS: CN may represent a promising option for selected pediatric patients with NK, with most reports describing improved corneal sensitivity and ocular surface stability. However, evidence remains limited by single case reports and small case series, heterogeneous outcome reporting, and low or very low certainty. Postoperative visual outcomes are variable.
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- Reply to Letter Regarding: PRESS & ROLL Technique for Descemet Membrane Endothelial Keratoplasty Graft Unfolding in Vitrectomized Eyes. [Letter]Cornea. 2026 Sep 17. [Online ahead of print]C
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- Safety and Efficacy of Mature Cultured Corneal Endothelial Cell Therapy (Vyznova) in Eyes With Declining Long-term Efficacy After Prototype Cell Transplantation. [Journal Article]Cornea. 2026 Sep 21. [Online ahead of print]C
- CONCLUSIONS: Administration of Vyznova was safe and demonstrated favorable clinical outcomes in eyes with declining long-term efficacy after initial treatment with prototype CECs. These findings support the feasibility of Vyznova as a treatment strategy for corneal endothelial failure in patients previously treated with cultured CECs.
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- Ocular Adverse Events Associated With Dupilumab: Analysis From a Real-World Database. [Journal Article]Cornea. 2026 Sep 21. [Online ahead of print]C
- CONCLUSIONS: Our study found a low frequency of documented ocular adverse events among patients treated with dupilumab. Although routine ophthalmic screening for all patients initiating dupilumab may not be necessary, prescribing physicians should remain vigilant for ocular surface inflammation, particularly in patients with atopic dermatitis, and promptly refer patients who develop ocular symptoms for ophthalmic evaluation.
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- Real-World Clinical Management of Keratoconus in Europe and the Middle East: A Multicountry Survey on Diagnostic and Surgical Practices (Keratoconus in Mind - KIM Project). [Journal Article]Cornea. 2026 Sep 21. [Online ahead of print]C
- CONCLUSIONS: This survey highlights substantial heterogeneity in the management of keratoconus across regions. At the same time, surgical indications align with recommendations from the 2015 global consensus on the definition and treatment of ectatic corneal diseases. However, discrepancies in diagnostic criteria and tool usage suggest the need to support harmonization of diagnostic and management approaches.
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- A Case of Leukemic Phase of Mantle Cell Lymphoma Diagnosed With Scarring Conjunctivitis and Bilateral Upper Palpebral Conjunctival Tumor. [Journal Article]Cornea. 2026 Sep 21. [Online ahead of print]C
- CONCLUSIONS: We report a case of leukemia-type MCL diagnosed with bilateral chronic cicatricial conjunctivitis and elevated lesions on the upper eyelid conjunctiva as initial findings. When encountering such findings, early pathological diagnosis and thorough systemic examination are important, with systemic malignant lymphoma in mind.
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- Letter Regarding: PRESS & ROLL Technique for Descemet Membrane Endothelial Keratoplasty Graft Unfolding in Vitrectomized Eyes. [Letter]Cornea. 2026 Sep 11. [Online ahead of print]C
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- Alcohol-Triggered Periocular Flushing Associated With Tacrolimus 0.1% Ophthalmic Solution in Sjögren-Related Ocular Surface Disease. [Journal Article]Cornea. 2026 Sep 16. [Online ahead of print]C
- CONCLUSIONS: Alcohol-triggered flushing, previously reported mainly with dermatologic calcineurin inhibitor formulations, may also occur during treatment with tacrolimus ophthalmic solution. Recognition of this self-limited reaction may prevent misdiagnosis and unnecessary discontinuation of an effective therapy.
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- Ocular Surface Disease as an Immune-related Adverse Event of Immune Checkpoint Inhibitor Therapy. [Journal Article]Cornea. 2026 Sep 09. [Online ahead of print]C
- CONCLUSIONS: Immune-mediated scleritis generated the strongest disproportionality signal in this analysis among PD-1 inhibitors, although these estimates are based on small case counts and wide confidence intervals and should be regarded as hypothesis-generating. Sicca syndrome and keratitis were reported across multiple ICI classes, with the keratitis signals for nivolumab and pembrolizumab supported by the largest case counts. As a disproportionality analysis, this study cannot establish incidence, comparative risk, or causality; the findings support clinical vigilance and further epidemiologic study rather than definitive causal conclusions. Physicians managing ICI-treated patients should have a low threshold for ophthalmological referral when ocular symptoms arise.
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- Recovery of Subbasal Nerve Density in Patients With Fuchs Endothelial Corneal Dystrophy After Descemet Membrane Endothelial Keratoplasty in Correlation to PROMs. [Journal Article]Cornea. 2026 Sep 04. [Online ahead of print]C
- CONCLUSIONS: This prospective study demonstrates that DMEK leads to near preoperative recovery of corneal nerve density. Furthermore, significant improvement in dry eye symptoms can be detected, and enhanced quality of life in patients with FECD, although corneal nerve density does not fully return to levels of healthy individuals.
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- Acanthamoeba and Microsporidia Coinfection Causing Refractory Stromal Keratitis in an Immunosuppressed Patient: A Case Report. [Journal Article]Cornea. 2026 Aug 31. [Online ahead of print]C
- CONCLUSIONS: Coinfection with Acanthamoeba and microsporidia should be considered in immunocompromised patients presenting with atypical, treatment-resistant keratitis. Prompt and parallel diagnostic evaluation-including corneal scraping, IVCM, culture, and PCR-based pathogen identification-is essential. When medical therapy fails, therapeutic keratoplasty may be required. Early comprehensive diagnosis may prevent disease progression and need for surgical intervention.
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- Management of Corneal Endothelial Failure in Eyes With a PreserFlo MicroShunt. [Journal Article]Cornea. 2026 Sep 02. [Online ahead of print]C
- CONCLUSIONS: Endothelial failure in eyes with PFM was observed mainly in eyes with further risk factors for endothelial impairment as Fuchs endothelial corneal dystrophy, pseudoexfoliation glaucoma, or multiple previous surgeries. DMEK with simultaneous or sequential intracameral tube shortening is a feasible option in this setting.
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- "Hybrid Docking" for Femtosecond Laser-assisted Deep Anterior Lamellar Keratoplasty: Combining Nonapplanating Trephination With Liquid Interface and Applanating Intrastromal Tunnel Preparation. [Journal Article]Cornea. 2026 Sep 04. [Online ahead of print]C
- CONCLUSIONS: FS-DALK using a hybrid docking approach effectively combines the advantages of nonapplanating and applanating laser steps. The nonapplanating incomplete vertical trephination ensures a perfectly circular trephination, eliminating the oval or "pear-shaped" distortions commonly associated with applanating systems. This refined approach facilitates a predictable "blunt big-bubble," minimizes the necessity for manual dissection, and significantly reduces the risks of intraoperative perforation and conversion to PKP.
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- Clinical Outcomes and In Vitro Growth Inhibition of Severe Fungal Keratitis Treated With Adjunct Rose Bengal Photodynamic Therapy (RB PDT). [Journal Article]Cornea. 2026 Sep 08. [Online ahead of print]C
- CONCLUSIONS: Adjunct RB PDT may reduce the need for surgical intervention and reduce recurrence rates in severe fungal keratitis, particularly in Fusarium infections.
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