- Palliative and end-of-life care on the battlefield: a scoping review. [Review]Crit Care. 2026 Sep 26; 30(1).CC
- CONCLUSIONS: Pain management in combat is a well-researched field, but one that is rarely examined in the specific context of end-of-life care. Similarly, there is a notable gap in the literature regarding palliative care in a combat context. Where such topics are addressed, they are often simply a transposition of civilian data. The lack of training and doctrinal guidance prevents the proper integration of this specialized care, which aims to ensure dignity for dying combatants and to reflect the values upon which military medicine is founded.
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- Polymyxin B hemoadsorption in endotoxic septic shock: ten questions on the Tigris trial. [Review]
- The Tigris trial recently reported that polymyxin B hemoadsorption (PMX) achieved a high posterior probability of benefit for mortality in adults with endotoxic septic shock (endotoxemia with multiple organ failure). The trial used a Bayesian framework with a prior derived from a subgroup of an earlier trial (EUPHRATES) and this subgroup was used to design eligibility criteria for Tigris. Ten que…
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- Comparison of two automated pupillometry indices in patients with acute brain injury: the prospective multicentre LYNX cohort study. [Multicenter Study]
- CONCLUSIONS: NPi and QPi were correlated and both predicted 6-month outcome, but QPi was far more sensitive to anaesthetics, which probably confounds its association with intracranial hypertension. The indices are not interchangeable in sedated critically ill patients.
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- Beyond macrocirculatory targets: a multimodal framework for microcirculatory and organ perfusion monitoring in sepsis. [Review]
- CONCLUSIONS: Microcirculatory monitoring should currently be viewed as a complementary framework for identifying persistent or heterogeneous tissue hypoperfusion beyond conventional macrocirculatory targets. Its integration into individualized resuscitation remains promising but requires standardized methodology, external validation, and prospective interventional evidence before any single modality or multimodal strategy can be adopted as a validated resuscitation endpoint.
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- Extrapolation of MAP trends predicts hypotension and vasopressor up-titration in the ICU. [Letter]
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- Early multimodal vasopressor strategy in septic shock: results of the TRICYCLE randomized controlled trial. [Randomized Controlled Trial]
- CONCLUSIONS: Early multimodal vasopressor therapy with Ang II, vasopressin and norepinephrine in patients with septic shock demonstrated promising physiological effects. These findings provide a rationale for a larger trial to assess whether early multimodal vasopressor therapy improves patient-centered outcomes.
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- Targeting capillary leak in experimental sepsis and endotoxemia: a systematic review of therapeutic agents, methods and models in animal studies. [Systematic Review]
- CONCLUSIONS: Preclinical research on sepsis-induced capillary leak is characterized by methodological heterogeneity, a disproportionately high rate of studies reporting capillary leak reduction, and an overreliance on endotoxemia models. Bridging the translational gap will require standardized assessment of capillary leak, broader use of live-pathogen large-animal models, post-treatment dosing paradigms, and clinical trials enriched for endothelial dysfunction.
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- A specialist-led interprofessional weaning program to prevent weaning failure in high-risk patients: the PRiVENT study. [Clinical Trial]
- CONCLUSIONS: The PRiVENT intervention was feasible and successful weaning was numerically more frequent in the intervention group, although the prespecified adjusted primary analysis did not reach statistical significance. These findings suggest a potential benefit of structured, multidisciplinary weaning support.
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- Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial. [Journal Article]
- CONCLUSIONS: Plasma ferritin does not identify patients with COVID-19 who benefit from treatment with anakinra, whilst anakinra may be beneficial in patients with low, rather than high, baseline plasma suPAR. These hypothesis-generating findings contrast with the results of clinical trials in non-critically ill patients with COVID-19.
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