- Pharmacovigilance Knowledge, Attitudes, and ADR Reporting Behaviour Among Physicians and Pharmacists in a Tertiary Hospital. [Journal Article]Curr Drug Saf. 2026 Sep 21. [Online ahead of print]CD
- CONCLUSIONS: Knowledge gaps and limited awareness remain important challenges in ADR reporting. Although pharmacists had higher pharmacovigilance knowledge, reporting rates were similar between groups. Targeted training programs may contribute to improving ADR reporting practices.
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- Possible Interaction of the Gut-selective Antibiotic Rifaximin with Carvedilol Associated with Transient Indirect Hyperbilirubinemia: A Case Report. [Case Reports]Curr Drug Saf. 2026 Sep 09. [Online ahead of print]CD
- CONCLUSIONS: This appears to be the first report of new-onset indirect hyperbilirubinemia with rifaximin in the presence of carvedilol in a patient with chronic liver disease of autoimmune etiology. Carvedilol-mediated P-glycoprotein inhibition represents a biologically plausible but unproven mechanism for overexposure to rifaximin. Clinical studies are warranted to assess the potential consequences of P-glycoprotein-mediated modulation of rifaximin pharmacokinetics in patients with chronic liver and renal disease.
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- Enhancing Patient Safety: Patterns of Adverse Drug Reaction Reporting in a Tertiary Care Hospital in Eastern India: A Record-based Retrospective Study. [Journal Article]Curr Drug Saf. 2026 Aug 03. [Online ahead of print]CD
- CONCLUSIONS: The ADR reporting pattern observed in this newly established tertiary healthcare facility in eastern India may help increase physicians' awareness of the importance of timely ADR reporting and support their clinical decision-making process.
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- Investigating the Therapeutic Potential of a Polyherbal Formulation in Progesterone-induced Obesity: Insights from Preclinical Studies. [Journal Article]Curr Drug Saf. 2026 Jul 27. [Online ahead of print]CD
- CONCLUSIONS: The formulation's efficacy in addressing obesity is likely attributable to the presence of polyphenols, saponins, and terpenoids. Histopathological examination of hepatic and adipose tissues further corroborated the anti-obesity efficacy of the polyherbal formulation. Future research will focus on isolating and identifying the active chemicals in both plants to better understand their composition.
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- Dapsone-Induced Photosensitivity: A Rare and Overlooked Clinical Dilemma. [Case Reports]Curr Drug Saf. 2026 Jul 27. [Online ahead of print]CD
- CONCLUSIONS: Although it is uncommon, dapsone-induced photosensitivity should be taken into account when patients exhibit photodermatoses while receiving treatment. Morbidity and unnecessary regimen discontinuation can be avoided with early detection followed by prompt care. This case emphasizes how crucial it is for physicians to be aware of this unusual side effect.
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- Clinical Experience with Quintuple Non-Insulin Drug Therapy in Suboptimally Controlled Type 2 Diabetes. [Journal Article]Curr Drug Saf. 2026 Jul 25. [Online ahead of print]CD
- CONCLUSIONS: The prevalence of individuals with T2D treated with quintuple non-insulin drug regimens was 2.7% without any notable side effects or safety concerns. In patients who refuse insulin therapy, these combinations can be taken into consideration according to the characteristics of every individual and carefully evaluated for their safety and effectiveness.
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- Optimizing Management of Newly Diagnosed T2DM Mellitus Through Combination Therapy: Efficacy, Safety, and Individualized Care Approaches. [Journal Article]Curr Drug Saf. 2026 Jul 24. [Online ahead of print]CD
- CONCLUSIONS: A proactive transition from sequential add-on therapy to initial combination regimens is necessary to optimize the management of newly diagnosed T2DM. Clinicians can optimize cardiometabolic benefits, guarantee long-term safety, and enhance overall quality of life by using a patient-centered, customized approach.
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- Pharmacists' Role in Ensuring Safe Handling and Administration of Anticancer Medications in India. [Journal Article]Curr Drug Saf. 2026 Jul 22. [Online ahead of print]CD
- Pharmacists play a significant role in oncology with respect to the safe handling and administration of anti-cancer drugs. This comprehensive review analyses pharmacists' roles, emphasising adherence to national and international safety standards and the implementation of institutional programs for protocols, training, and certification. Pharmacists will aid in the formulation and adjustment of c…
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- Fluoroquinolone-induced liver injury and pharmacists' interventions in pneumonia: a case report and clinical pharmacist intervention. [Case Reports]Curr Drug Saf. 2026 Jul 16. [Online ahead of print]CD
- Background The diagnosis of drug-induced liver injury (DILI) is difficult due to insufficient awareness of DILI and the lack of specific objective diagnostic tests. The importance of pharmacists' care during hospitalization is underestimated. Our aim is to review the clinical features of fluoroquinolone-induced liver injury and to highlight the importance of pharmacists' intervention in fluoroqui…
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- Recognizing Subtle Neurological Adverse Effects of Fluoroquinolones: A Case Report of Isolated Dysarthria. [Case Reports]Curr Drug Saf. 2026 Jul 03. [Online ahead of print]CD
- CONCLUSIONS: This case report highlights the importance of quickly identifying even mild neurological problems in fluoroquinolone-treated patients, especially when risk factors are present. In a broader sense, it upholds the concepts of patient safety and therapeutic appropriateness, which state that drugs should only be used when necessary and should be stopped immediately if they have negative side effects. In this regard, strict adherence to the current regulatory cautions about fluoroquinolones is necessary.
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- Explainable Artificial Intelligence in Pharmacovigilance and Drug Safety: A Systematic Review of Enhancing Transparency and Regulatory Acceptance. [Journal Article]Curr Drug Saf. 2026 Jun 24. [Online ahead of print]CD
- CONCLUSIONS: In clinical applications associated with drug safety, emerging areas of research should be targeted towards collaborations, evaluations, and XAI design adaptable to meeting growing demands for operation, acceptability, and patient safety.
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- Intravenous Methylcobalamin-Induced Anaphylactic Shock: A Case Report. [Case Reports]Curr Drug Saf. 2026 Jun 12. [Online ahead of print]CD
- CONCLUSIONS: Anaphylactic shock, after slow intravenous methylcobalamin injection, is an uncommon but potentially serious adverse effect. The purpose of this case report is to highlight the importance of this rare but serious life-threatening adverse effect. To our knowledge, this is the first reported case of intravenous methylcobalamin-induced anaphylactic shock. Physicians and healthcare teams should be cautious while administering methylcobalamin to patients, especially via the intravenous route.
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- Nasal Bleeding as a Potential Side Effect of Omega-3 Fatty Acids: A Case Report. [Case Reports]Curr Drug Saf. 2026 Apr 01. [Online ahead of print]CD
- CONCLUSIONS: The potential of omega-3 FA supplementation to increase risk of bleeding, even at typical doses used in clinical trials, should be considered as demonstrated in this case.
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- Pharmacovigilance Analysis of Azelastine-Related Adverse Events: Insights from the FDA FAERS Database (2006-2024). [Journal Article]Curr Drug Saf. 2026 Jun 02. [Online ahead of print]CD
- CONCLUSIONS: This study systematically depicts the safety profile of azelastine by analysing large-scale adverse reaction data and provides empirical evidence for the improvement of clinical dosing guidelines and risk communication strategies. Pharmacovigilance departments should maintain vigilance for rare but serious adverse reactions to azelastine to optimize its risk-benefit profile.
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- Assessing the Risk of Drug-Induced Influenza-Like Illness: A Disproportionality Analysis of Two Decades of FAERS Data (2004-2025). [Journal Article]Curr Drug Saf. 2026 May 19. [Online ahead of print]CD
- CONCLUSIONS: This first comprehensive FAERS study identifies key drugs associated with ILI, including interferon β-1a, evolocumab, ofatumumab, interferon β-1b, and zoledronic acid. Clinical monitoring for drug-induced ILI is essential to enhance medication safety.
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