Pre-eclampsia remains a leading cause of maternal and perinatal morbidity and mortality worldwide, yet no disease-modifying therapy currently exists. This review examines the challenges inherent in developing therapeutics for pre-eclampsia, and evaluates the evidence for repurposing existing drugs and developing novel biologic strategies to treat preterm pre-eclampsia.

We aimed to examine how inaccuracies and inequities in blood pressure (BP) measurement across office, ambulatory, home, and emerging cuffless modalities contribute to disparities in hypertension diagnosis and control, and to identify strategies to improve measurement equity.

Blood pressure (BP) follows a robust circadian rhythm and disruption of this rhythm is associated with hypertension and increased cardiovascular disease risk. This review discusses the current understanding of how circadian mechanisms regulate the neural control of BP, with a focus on autonomic brain circuits, local molecular clocks, and emerging neuroimmune mechanisms contributing to the regulation of BP.

Orthostatic hypertension (oHT) is increasingly recognized as a clinically relevant but poorly understood disorder of autonomic blood pressure control. This review aims to summarize the current understanding of the clinical spectrum and pathophysiology of oHT, evaluate its prognostic significance, and identify key gaps in knowledge to guide future mechanistic and clinical studies.

This review synthesizes evidence on the association between sleep and hypertension from the past five years, with an emphasis on sex differences in blood pressure regulation.

Hypertensive disorders of pregnancy, including gestational hypertension and preeclampsia are a leading cause of maternal morbidity and mortality and confer substantial short- and long-term cardiovascular risk. This review summarizes current evidence regarding the classification, pathophysiology, acute and longitudinal management, and cardiovascular implications of postpartum hypertension, while highlighting emerging strategies to improve outcomes.

This review examines determinants across structural, institutional, interpersonal, and individual domains that contribute to hypertensive disorders of pregnancy (HDPs) in American Indian and Alaska Native (AI/AN) populations and their long-term cardiovascular consequences. It suggests paths forward for equitable research and clinical practice.

To evaluate the crosstalk between the liver, heart, and kidneys in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), highlighting the distinct regulatory roles of non-traditional hepatokines, and to assess shared therapeutic targets and molecular mechanisms driving cardiorenal complications in MASLD patients.

To summarize the prospective and experimental evidence examining occupational physical activity (OPA) and hypertension-related outcomes, discuss potential physiological mechanisms, and identify methodological challenges contributing to heterogeneity across studies.

Obesity rates have increased dramatically during the past four decades, and these increases have occurred in children and adolescents, as well as in adults at reproductive age. Currently, 40.3% of men and 39.7% of women 20-39 years of age in the United States are classified as obese, leading to a substantial rise in parental obesity. Obesity is a major risk factor for cardiovascular, metabolic and renal diseases, including hypertension, type 2 diabetes, and chronic kidney diseases. This review examines current evidence of how parental obesity programs offspring susceptibility to cardiorenal and metabolic dysfunction and discusses the potential underlying mechanisms that contribute to the long-term health consequences in the offspring.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a systemic cardiometabolic disease. This review summarizes recent advances in epidemiology, pathophysiology, biomarkers, and treatment relevant to cardiovascular risk assessment and management.

To review contemporary evidence regarding optimal aspirin dosing for prevention of preeclampsia, focusing on dose-response relationships, timing of initiation, and phenotype-specific prophylaxis.

Tissue perfusion is tightly regulated by central neural circuits that integrate autonomic and sensory inputs to match blood flow to tissue metabolic demand. This review synthesizes current knowledge on the central mechanisms governing tissue perfusion in both physiological and pathological states, with emphasis on the organization of brain networks involved in cardiovascular control.