To survive the proteotoxic and oxidative stress that are prototypical of rapidly multiplying cells, cancer cells must successfully navigate two existential threats: the danger of protein misfolding in the endoplasmic reticulum and the peril of iron-catalyzed peroxidation of membrane lipids. Over the past few decades, the cellular responses to these pressures have been studied independently. This review underscores emerging evidence coupling two erstwhile distinct cellular processes: (i) the unfolded protein response (UPR) that acts as a guardian of proteostasis and a crucial metabolic rheostat, through its three arms (IRE1α, PERK, and ATF6) and (ii) ferroptosis that leads to cell death due to iron-dependent accumulation of lethal levels of lipid peroxides.

This review summarizes current evidence on interventional therapies for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT), compares the treatment strategies between East and West, and proposes a practical framework for patient selection in the immunotherapy era of HCC.

Acute myeloid leukemia (AML) exemplifies how malignant transformation can be driven by both epigenetic deregulation and genetic mutation. Aberrant DNA methylation, histone modifications, and chromatin remodelling cooperate to block myeloid differentiation, sustain leukemic self-renewal, and promote immune evasion. This review examines the molecular mechanisms underlying epigenetic dysregulation in AML and highlights recent advances in epigenetic and immune-based therapeutic strategies.

Gastric cancer (GC) is a leading cause of cancer death globally. Platinum‑based drugs, fluoropyrimidines, and docetaxel are standard for advanced disease, but intrinsic and acquired resistance limit the efficacy. This review summarizes chemoresistance mechanisms, focusing on the roles of various cell death pathways in GC chemoresistance, as well as the involvement of non-coding RNAs (ncRNAs) in modulating drug resistance through multiple regulatory mechanisms. We also describe models for establishing resistant cell lines (stepwise dose escalation, high-dose intermittent pulse selection, gene transfection).

This study aims to identify complications and difficulties in oncology patients undergoing dental implant osseointegration, considering the impact of treatment on the microarchitecture of the craniofacial region, the oral cavity microbiome, and oral cavity inflammation.

Sarcomas are rare and heterogeneous malignancies for which molecular diagnostics increasingly complement histopathology, immunohistochemistry, FISH, and RT-PCR. This review summarizes the main research applications of next-generation sequencing (NGS) in sarcoma, with particular attention to mutation and variant discovery, fusion detection, biomarker development, assay validation, multi-omics integration, and the boundaries between exploratory research and clinical implementation.

This review highlights the major unmet needs in diagnosis and treatment of digestive neuroendocrine carcinomas (NEC) and describes the current and evolving evidence on these aspects.

Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by a distinct geographical distribution. Effective surveillance is crucial for the early detection of recurrence or metastasis and for improving patient prognosis.This review systematically examines current NPC follow-up protocols and recent developments to inform individualized precision surveillance.

To examine how biological sex and gender influence the tumorigenesis of neuroendocrine neoplasms (NEN), integrating epidemiological evidence with hormonal, molecular, lifestyle and environmental factors.

Oral cavity cancer (OCC) is a significant clinical challenge within head and neck oncology. It is characterized by significant morbidity, high recurrence rates, and only modest improvements in long-term survival over recent decades. Recent advances in metagenomics and high-throughput sequencing have revealed that oral microbial dysbiosis contributes to tumorigenesis, highlighting the potential of microbiome-derived biomarkers for early detection and prognosis of OCC. The purpose of the work is to discuss oral microbiome alterations in OCC.

Antibody-drug conjugates (ADCs) have reshaped the therapeutic landscape of advanced gastric cancer, with trastuzumab deruxtecan (T-DXd) and disitamab vedotin (RC48) establishing new standards for HER2-positive disease, and a wave of Claudin 18.2 (CLDN18.2)-directed ADCs demonstrating promising early efficacy. However, as the arsenal of effective ADCs expands, clinicians increasingly confront a question that existing guidelines leave unanswered: how should ADCs be sequenced after disease progression?

Tele-health has evolved from a marginal tool confined to rural populations and selected follow-up programs into a structurally integrated component of modern cancer care. Prior to COVID-19, its adoption was constrained by regulatory fragmentation, non-uniform reimbursement, and licensure barriers. This narrative review evaluates the evolutionary integration of tele-health in oncology post-COVID-19, examines digital disparities across patient populations, and addresses the medico-legal implications of this integration, with the objective of providing a comprehensive and clinically actionable framework for the governance of virtual oncology care.

Summarize recent advances in interventional oncology for the management of neuroendocrine tumor liver metastases (NETLMs), with a focus on evolving evidence for embolization and ablation, integration with systemic therapies, and emerging approaches.

Obesity increases the risk of at least 13 malignancies. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) produce substantial weight loss and improve metabolic and inflammatory pathways implicated in carcinogenesis. This review critically examines the preclinical, epidemiologic, randomized-trial, and emerging oncology evidence linking these agents to obesity-related cancer incidence and outcomes.