(Curr Opin Infect Dis[TA])
2,426 results
  • Aspergillus-Mucorales co-infections: implications for first-line antifungal treatment? [Journal Article]
    Curr Opin Infect Dis. 2026 Oct 14. [Online ahead of print]Felber D, Hoenigl M, … Sedik SCO
  • CONCLUSIONS: Clinicians should estimate Mucorales probability from host factors, prior prophylaxis, imaging, and local epidemiology and deploy PCR early. If the estimated probability is ~10% (consider at 5%), start a Mucorales-active first-line therapy while diagnostics proceed. Decisions must balance toxicity and organ function against the high cost of delay. Research should validate risk models, refine definitions/algorithms, and test new agents up-front.
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  • Optimizing cefiderocol use in clinical practice. [Journal Article]
    Curr Opin Infect Dis. 2026 Oct 27. [Online ahead of print]Sharara SL, Hsu AJ, … Tamma PDCO
  • CONCLUSIONS: With its unique structure and broad activity against resistant gram-negative pathogens, cefiderocol represents an important and evolving addition to the AMR therapeutic landscape.
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  • Screening for multidrug-resistant organism: clinical benefit or unquestioned routine. [Journal Article]
    Curr Opin Infect Dis. 2026 Oct 12. [Online ahead of print]Soriano A, Ulldemolins M, … Mensa JCO
  • CONCLUSIONS: We propose that physiological bacterial translocation from the intestinal microbiota is a common phenomenon and may represent one of the mechanisms of bloodstream infection in critically ill and immunocompromised patients. In this model, progression to invasive infection depends on intestinal pathobiont burden exceeding the capacity of host immune clearance. If validated, this concept would support a transition from qualitative MDRO screening to quantitative assessment of intestinal pathobiont burden to guide antimicrobial stewardship and targeted preventive strategies.
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  • Endemic Mycoses in 2026: can we keep the pace of redrawing maps? [Journal Article]
    Curr Opin Infect Dis. 2026 Sep 18. [Online ahead of print]Araujo de Oliveira Santana M, Zuniga-Moya JC, … Spec ACO
  • CONCLUSIONS: Climate change, human mobility, socioeconomic disparities, and a growing immunosuppressed patient population affected the geographic distribution of dimorphic fungal infections and will challenge mycologist to keep up with the pace of redrawing the maps for these infections. There is a need for more research and public health initiatives in this field. Clinicians should have a high index of suspicion for dimorphic fungal infections, and all patients with compatible syndromes should receive appropriate testing, even in historically nonendemic areas.
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  • Adenovirus infection after cellular therapy: diagnostic and therapeutic challenges. [Journal Article]
    Curr Opin Infect Dis. 2026 Sep 18. [Online ahead of print]Yap N, Wang NY, … Haeusler GMCO
  • CONCLUSIONS: HAdV remains an important cause of morbidity and mortality following HCT, particularly in patients with impaired T-cell immunity. Key challenges include optimal surveillance strategies, treatment thresholds, and management of high-risk patients. Advances in molecular diagnostics, standardized disease definitions, brincidofovir, and virus-specific T-cell therapies may facilitate higher quality clinical research and support more standardized, evidence-based approaches to HAdV management.
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  • Machine learning to differentiate colonization from infection in multidrug-resistant Gram-negative bacteria: implications for further research. [Journal Article]
    Curr Opin Infect Dis. 2026 Aug 27. [Online ahead of print]Giacobbe DR, Ceccardi E, … Bassetti MCO
  • CONCLUSIONS: The main challenge for machine learning in predicting MDR-GNB infection in colonized patients may lie not in developing increasingly sophisticated algorithms, but in generating clinically representative datasets and adopting rigorous methodological standards for model development, validation, calibration, and implementation. Future research should prioritize clinically meaningful target populations and demonstrate improvements in patient outcomes and antimicrobial stewardship beyond conventional measures of predictive performance.
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  • Fungal diseases in burn and blast-injured patients: tensions are rising, and awareness must keep pace. [Journal Article]
    Curr Opin Infect Dis. 2026 Sep 02. [Online ahead of print]Dudoignon E, Mhenni R, Dellière SCO
  • CONCLUSIONS: Optimal management of IFD in burn patients requires a multidisciplinary approach combining immune risk stratification, refined diagnostic algorithms, and individualized antifungal therapy. Consensus on case definitions and prospective multicentre data are urgently needed to consolidate the evidence base and meaningfully improve outcomes in this vulnerable population.
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  • Managing KPC infections in daily practice: when BLBLIs are interchangeable - and when they are not. [Journal Article]
    Curr Opin Infect Dis. 2026 Oct 09. [Online ahead of print]Rapti V, Karaiskos I, … Study Group for the Combat of Antimicrobial Resistance in Critically Ill Patients of the Hellenic Society of ChemotherapyCO
  • CONCLUSIONS: BLBLI with KPC activity interchangeability is clinically reasonable only in selected, microbiologically confirmed, low-risk scenarios. In complex infections, therapy should be guided according to resistance mechanism, infection site, pharmacokinetics/pharmacodynamics (PK/PD) parameters, and host factors.
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  • Alveolar echinococcosis. [Review]
    Curr Opin Infect Dis. 2026 Oct 01; 39(5):387-395.Stojković M, Junghanss T, Gehling KG
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  • CONCLUSIONS: Treatment options for alveolar echinococcosis have not changed in decades. Cure is only available for early and limited hepatic disease amenable to R0-surgical resection. Advanced disease, ineligible for surgery, is treated with benzimidazoles with a parasitostatic effect on Echinococcus multilocularis. The prognosis of alveolar echinococcosis ranges from excellent to poor depending mainly on the extent of hepatopathy induced by irreversible damage to the biliary and vascular system of the liver. Benzimidazole intolerance dramatically worsens prognosis, as parasitic growth cannot be suppressed in inoperable patients.
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