(Curr Opin Ophthalmol[TA])
2,793 results
  • Clinical applications of artificial intelligence in myopia: beyond algorithms to real-world implementation. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):421-427.Wong MYZ, Ang MCO
  • CONCLUSIONS: The principal challenges facing AI in myopia care are implementation, regulation, economics and clinician trust. Future progress will depend not only on algorithmic performance but also on prospective implementation studies, demonstrable economic value and robust governance frameworks. Successful translation will ultimately require demonstration of clinical value within real-world healthcare systems.
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  • Retinal manifestations of neglected tropical diseases. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):458-468.Zhao AT, Wibbelsman TD, Deaner JDCO
  • CONCLUSIONS: Recognition of retinal manifestations is crucial for NTD diagnosis and management. Ophthalmologists must maintain high clinical suspicion based on travel history and systemic symptoms. Collaborative care with infectious disease specialists and utilization of appropriate diagnostic modalities facilitate optimal outcomes and prevent vision loss while addressing broader public health implications.
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  • Molecular biomarker profiling in noninfectious uveitis: a chronological review of discovery. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):448-457.Pothikamjorn TL, Gonzales JACO
  • CONCLUSIONS: Biomarker research has transformed the understanding of NIU from a clinically defined syndrome into a group of molecularly distinct immune disorders. Advances spanning autoantigens, genetics, immune-cell profiling, cytokines, chemokines, and multiomics have revealed novel pathogenic mechanisms and therapeutic targets. Integration of these biomarkers with targeted therapies may accelerate the transition toward precision medicine in uveitis care.
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  • Vibe coding for ophthalmologists. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):428-433.Antaki F, Bellanda V, … Ong AYCO
  • CONCLUSIONS: Vibe coding provides ophthalmologists with a pragmatic pathway to translate unmet needs into executable prototypes. For low-risk applications that do not directly influence clinical decision-making, clinicians may in certain settings be able to deploy vibe-coded tools independently. For higher risk applications, vibe coding does not replace professional software development, but it enables experimentation, clarifies user needs, and makes ideas more tangible. With appropriate guardrails, vibe coding can accelerate clinician-led innovation while preserving safety and accountability.
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  • Artificial intelligence-guided engineering of precision ocular therapeutics. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):413-420.Sayana R, Wang SK, … Guo LYCO
  • CONCLUSIONS: Artificial intelligence tools may influence the landscape of ophthalmic drug discovery, from nominating small molecule candidates to co-designing next-generation gene therapy vectors. Rigorous experimental validation remains essential; artificial intelligence-nominated candidates and predictions must be tested empirically to confirm their safety, biological relevance, and therapeutic efficacy.
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  • Long-term safety of steroid-sparing immunosuppression in uveitis. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):442-447.Placide J, Uner OE, Suhler EBCO
  • CONCLUSIONS: Steroid-sparing agents appear to have excellent long-term safety when the agent is matched to disease severity and patients are screened and monitored proactively. The safest agent is the one whose specific toxicity is anticipated and managed.
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  • Update on imaging biomarkers in uveitis. [Review]
    Curr Opin Ophthalmol. 2026 Nov 01; 37(6):436-441.Pichi FCO
  • CONCLUSIONS: Most proposed imaging biomarkers remain disease-specific and incompletely validated. Recent quantitative approaches and international consensus frameworks may narrow the gap between descriptive imaging and actionable, trial-ready biomarkers. The bottleneck has shifted from image acquisition to validation, harmonization, and integration with clinical outcomes.
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  • Traumatic macular hole: observe, operate, or other options. [Review]
    Curr Opin Ophthalmol. 2026 Sep 01; 37(5):397-401.Muste JC, DeSimone JD, Yonekawa YCO
  • CONCLUSIONS: The association between earlier surgery and better visual outcomes in the literature requires careful interpretation due to case-mix confounding. A systematic, optical coherence tomography-guided approach integrating hole characteristics, patient age, and associated ocular injuries allows individualized management of TMH. Continued refinement of surgical techniques is promising for large and refractory holes.
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  • Corneal Allogeneic Intrastromal Ring Segments for keratoconus - recent evidence and the move to customized and custom shaped CAIRS. [Review]
    Curr Opin Ophthalmol. 2026 Jul 01; 37(4):289-298.Jacob S, Awwad ST, Agarwal ACO
  • CONCLUSIONS: CAIRS is evolving into a customizable corneal contouring approach that may complement and potentially reduce reliance on, existing treatment modalities. When combined with corneal cross-linking, it offers both biomechanical stabilization and visual rehabilitation. Future advances are likely to center on data-driven personalization tailored to each patient's corneal phenotype and visual needs, an approach that becomes increasingly important as CAIRS use expands in keratoconus.
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