- Investigation of the correlation between serum levels of interleukin-6 and clinical and paraclinical findings in COVID-19 patients. [Journal Article]
- CONCLUSIONS: Elevated serum IL-6 strongly reflects disease severity and adverse outcomes in COVID-19, highlighting its potential as a prognostic biomarker to guide clinical assessment and management.
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- Population pharmacokinetic modeling of adalimumab biosimilar SCT630 and Humira® in healthy participants and patients with moderate to severe plaque psoriasis to establish PK similarity. [Journal Article]
- CONCLUSIONS: This analysis integrated data from both healthy participants and patients with PsO, and provided a valuable assessment of adalimumab PK characteristics and significant covariates. This model-based approach further elucidates how the SCT630 PK profile compares to that of Humira® in healthy participants and patients with PsO, supporting the totality-of-evidence for the biosimilarity of SCT630.
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- Glucagon enhances subcutaneous insulin absorption: Pilot experiments in pigs. [Journal Article]
- CONCLUSIONS: These experiments in pigs suggest that micro-amounts of glucagon, when injected at the same SC site as insulin, may speed up and enhance the early absorption of a single SC insulin bolus.
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- Prevalence and correlates of antinuclear antibodies in a Japanese community sample: a cross-sectional study. [Journal Article]
- CONCLUSIONS: These data provide a population-specific baseline for ANA positivity in a Japanese community sample and confirm that prevalence is higher in women and varies with age. Because ANA is frequently measured and may precede autoimmune disease, longitudinal studies are needed to clarify whether incidental positivity in healthy individuals carries prognostic significance.
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- Paclitaxel, carboplatin, and cetuximab induction chemotherapy for locally advanced head and neck squamous cell carcinoma: A retrospective evaluation of treatment outcomes and safety. [Journal Article]
- CONCLUSIONS: PCE induction was feasible, with a high rate of CRT completion and acceptable tolerability. PFS was longer in the PCE group after limited adjustment, whereas OS did not differ significantly. Given the retrospective, nonrandomized design, residual confounding, and shorter follow-up in the PCE group, these findings are hypothesis-generating and require confirmation in larger, prospective studies.
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- Potential interactions between creatine supplementation and prescription drugs: a narrative review and evidence-mapping perspective. [Review]
- CONCLUSIONS: Despite widespread real-world co-use of creatine supplements and prescription medications, no controlled human studies have directly evaluated creatine-drug interactions. Available evidence from creatine-drug interaction resources suggests predominantly low-severity, theoretical interaction signals rather than clinically confirmed interaction risk. However, the absence of documented clinical evidence should not be interpreted as evidence that interactions cannot occur, particularly in high-risk populations. These findings highlight a substantial evidence gap and underscore the need for targeted human studies to inform clinical guidance.
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- Dna aneuploidy and urothelial carcinoma: A meta-analysis. [Review]Curr Ther Res Clin Exp. 2026 Dec; 105:100842.CT
- CONCLUSIONS: Our meta-analysis showed the clinical value of DNA aneuploidy and its prognostic value in UC.
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- U-Shaped Association Between Serum Vitamin B12 and All-Cause Mortality in Adults With Obesity in the United States: A Prospective Cohort Study. [Journal Article]
- CONCLUSIONS: All-cause mortality in the population with obesity showed an approximately U-shaped association with serum vitamin B12 levels. Maintaining serum B12 levels within 300 to 500 pmol/L is associated with a lower mortality risk. Owing to its observational design, causality cannot be inferred. Dynamic monitoring of vitamin B12 levels may help identify individuals at increased risk; however, further studies are needed to establish causality.
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- Treatment satisfaction and patient preference for efanesoctocog alfa over previous hemophilia A treatment: Results from the XTEND-1 phase 3 clinical trial. [Journal Article]
- CONCLUSIONS: Prophylactic efanesoctocog alfa was preferred to prior prophylactic regimens by most patients and improved patient satisfaction at 52 weeks.
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- The effect of ascorbic acid supplementation on plasma leptin and adiponectin levels: Systematic review of in vivo and in vitro studies. [Review]Curr Ther Res Clin Exp. 2026 Dec; 105:100838.CT
- CONCLUSIONS: This systematic review demonstrates a positive relationship between AA and adiponectin and inverse relationship with leptin.
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- Prostate cancer initially misdiagnosed as prostatic abscess in a 36-year-old kidney transplant recipient. [Case Reports]Curr Ther Res Clin Exp. 2026 Dec; 105:100841.CT
- Renal transplant recipients (RTRs) have a 2-4 fold increased risk of malignancy due to long-term immunosuppression. We report a diagnostically challenging case of a 36-year-old man with a 16-year history of renal transplantation who presented with perineal pain, fever, and rising prostate-specific antigen (PSA), initially diagnosed as prostatic abscess. Ultrasound-guided aspiration yielded bloody…
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- Association Between Perioperative Daprodustat Use and Early Posttransplant Graft Function in Living Donor Kidney Transplantation: A Propensity Score-Matched Retrospective Study. [Journal Article]Curr Ther Res Clin Exp. 2026 Dec; 105:100837.CT
- CONCLUSIONS: These findings raise the possibility that perioperative daprodustat use may be associated with improved early graft function in LDKT, warranting further investigation.
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- Association Between the Use of Gabapentinoids and Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis. [Review]Curr Ther Res Clin Exp. 2026 Dec; 105:100836.CT
- CONCLUSIONS: Overall, there was no significant association with gabapentinoids. However, gabapentin and pregabalin were linked to increased risk of exacerbations. Therefore, future long-term studies are required to establish this association with underlying biological mechanisms. [PROSPERO ID: CRD420251248968].
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- Aptamers in Ocular Disease Therapy and Drug Delivery: Current Progress and Future Opportunities. [Review]
- CONCLUSIONS: The available evidence demonstrates a diverse and rapidly expanding repertoire of aptamers developed for ocular diseases, underscoring their versatile potential as next-generation platforms for therapeutic, biomarker-guided diagnosis, and targeted drug delivery in ophthalmology.
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- Monoclonal Antibodies in Pediatric Atopic Dermatitis; Efficacy and Safety. [Review]Curr Ther Res Clin Exp. 2026 Dec; 105:100833.CT
- CONCLUSIONS: A systemic immunomodulatory medication (monoclonal antibodies) is frequently required for moderate to severe AD as supplementary treatment. Dupilumab has received FDA approval for pediatric AD. Further clinical trials are needed for other mAbs before they are used in children.
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