To review community-based pharmacist-led medication titration across cardiometabolic conditions and the infrastructure needed to deliver this model at scale.

Depression and cardiovascular disease (CVD) frequently co-occur and contribute substantially to global morbidity and mortality. This narrative review synthesizes current evidence on the biological, psychological, and clinical mechanisms connecting these two conditions. The aim is to clarify the key pathways underlying their bidirectional relationship and to highlight therapeutic strategies that may improve outcomes in individuals affected by both disorders.

Recently approved by the United States Food and Drug Administration, [18]F-flurpiridaz for positron emission tomography (PET) myocardial perfusion imaging (MPI) enables high-quality assessment of myocardial blood flow (MBF). Its half-life of approximately 110 min supports regional distribution and allows unit-dose delivery. These features make this probe well suited for MBF quantitation and expand access to quantitative cardiac PET at smaller centers.

This review aims to evaluate the contemporary and evolving role of cardiac magnetic resonance (CMR) imaging in arrhythmic risk stratification for patients with non-ischaemic cardiomyopathy, specifically focussing on dilated cardiomyopathy (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC). This review synthesises current data on late gadolinium enhancement (LGE), parametric mapping, strain imaging and artificial intelligence (AI), and contextualises these among emerging genetic risk stratification approaches.

Fixed-dose combination therapy (the polypill) was developed to reduce treatment complexity and improve adherence to evidence-based cardiovascular therapies. This review evaluates contemporary evidence for its effects on major cardiovascular events and cardiovascular mortality across primary prevention, secondary prevention, and emerging heart failure applications, while addressing implementation barriers and remaining evidence gaps.

Periodontal disease has been increasingly recognized as a chronic inflammatory condition with potential systemic implications, particularly in the cardiovascular system. Heart failure (HF), a pro-inflammatory syndrome with multisystem involvement, remains a major public health burden. This state-of-the-art narrative review aims to analyze the current scientific evidence on the association between periodontal disease and heart failure, emphasizing epidemiological data, cardiac biomarkers, inflammatory mediators, and future perspectives.

Cardiac implantable electronic device (CIED) infection remains one of the most serious complications of device therapy, causing significant morbidity, mortality, healthcare utilization, and costs. Despite advances in device technology and preventive strategies, infection rates have not declined and may be increasing. This review summarizes current evidence on CIED infection prevention and device pocket management, with a focus on risk-based prevention, procedural strategies, and emerging technologies.

Myocardial perfusion imaging with SPECT and PET is commonly used to assess coronary artery disease, but its role in liver transplant candidates remains incompletely defined. This review examines how cirrhotic physiology affects pharmacologic stress imaging and summarizes current evidence for the use of SPECT, PET, and quantitative perfusion measures in this population.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular, kidney, and metabolic outcomes, but equitable access remains a major challenge. This review synthesizes U.S. evidence on disparities in their use and proposes an Equity-First Framework for cardiovascular-kidney-metabolic care to advance pharmacoequity.

Catheter ablation (CA) has become a first-line option for rhythm control strategy for atrial fibrillation (AF) and atrial flutter (AFL). We synthesize recent evidence regarding racial and ethnic disparities in CA utilization in the United States and examine the structural mechanism driving them.

The left atrial appendage (LAA) is nowadays recognized as both an arrhythmogenic substrate and the dominant source of thromboembolism in atrial fibrillation (AF). In this review we tried to summarize recent data on the anatomy, physiology, and imaging of the LAA, and examine how these findings help guide rhythm-control and stroke-prevention strategies.

The 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for managing patients with acute coronary syndromes (ACS) is the first major update since the 2013-2015 ST-elevation myocardial infarction (STEMI) and non-ST elevated myocardial infarction (NSTEMI) guidelines. It brings both conditions together into a single framework. This review covers the most important new and revised recommendations and points out where evidence is still lacking.

This review summarises recent advances in cardiac involvement in eosinophilia, with particular emphasis on pathophysiology, diagnostic challenges and therapeutic options.

To examine the relationship between health-related social needs, specifically food insecurity, housing instability, and transportation barriers, interventions to address those needs, and cardiovascular health outcomes.