- Complications and Safety Profile of XEN[®] Gel Stent in Glaucoma: A Five-Year MAUDE Database Analysis. [Journal Article]Curr Eye Res. 2026 Sep 16; :1-6. [Online ahead of print]CE
- CONCLUSIONS: Over five years, the MAUDE database has revealed that the most common issues with the XEN[®] Gel Stent involve device-related problems like resistance and blockage, as well as patient complications. While the data comes from voluntary reports and has its limitations, these real-world insights are valuable.
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- Redistribution of Aquaporin Proteins in Retinal Blood Vessels in Human Diabetic Retinopathy. [Journal Article]Curr Eye Res. 2026 Sep 10; :1-13. [Online ahead of print]CE
- CONCLUSIONS: The novel localization of AQP1 within the vessel wall may reflect altered spatial organization of water transport pathways within retinal vessel walls, contributing to impaired contractile function. These findings indicate that alterations in aquaporin distribution may be associated with vascular remodeling observed in DR.
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- Correlation of Aqueous Humor Dopamine with Axial Length and Its Regulation by TGFβ2 in Myopia. [Journal Article]Curr Eye Res. 2026 Sep 09; :1-11. [Online ahead of print]CE
- CONCLUSIONS: Lower AH DA is associated with longer AL in high-myopia eyes. The animal and cell data support a TGFβ2-DRD5-NF-κB axis in RPE inflammatory activation, suggesting that impaired dopaminergic signaling may contribute to myopia-associated axial elongation.
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- Protective Effects of Fushiming Against Microwave Radiation-Induced Retinal Damage: A Network Pharmacology and Experimental Study. [Journal Article]Curr Eye Res. 2026 Sep 08; :1-11. [Online ahead of print]CE
- CONCLUSIONS: The present results indicate that Fushiming can prevent microwave radiation-induced retinal damage by enhancing antioxidant pathways and inhibiting angiogenesis-related processes.
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- Head vs Screen-Mounted Eye Trackers: Comparisons Across Ethnic Diversity. [Journal Article]Curr Eye Res. 2026 Sep 08; :1-9. [Online ahead of print]CE
- CONCLUSIONS: This study identified variation in eye tracker performance depending on the tracker placement, and participant iris color or skin type. Both trackers exhibited similar gaze errors, but only the SMT showed acceptable precision via test-retest reliability. These data highlight the need for further research to ensure equitable application of eye trackers in diverse populations, and how iris color or skin type might affect gaze error and reliability.
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- Eriocitrin Alleviates Choroidal Neovascularization by Promoting the Activities of Mitogen-Activated Protein Kinase Phosphatase-1 In Vivo and In Vitro. [Journal Article]Curr Eye Res. 2026 Sep 07; :1-10. [Online ahead of print]CE
- CONCLUSIONS: Eriocitrin alleviates choroidal neovascularization by promoting mitogen-activated protein kinase phosphatase-1 activity in choroidal endothelial cells, thereby inhibiting the p38 and JNK signaling pathways. These findings suggest eriocitrin as a potential therapeutic agent for choroidal neovascularization.
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- Neuroprotective Effect of Oral Pemafibrate with Suppression of p-ULK1 Elevation in a Rat Ocular Hypertension-Induced Glaucoma Model. [Journal Article]Curr Eye Res. 2026 Aug 28; :1-8. [Online ahead of print]CE
- CONCLUSIONS: These results suggest that pemafibrate may have neuroprotective effects associated with suppression of OHT-induced p-ULK1 Ser757 elevation. Because autophagic flux was not directly measured, the present findings suggest a possible modulatory role in autophagy-related signaling rather than demonstrating restoration of autophagy function.
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- Association of Principal Component Analysis-Derived Optical Coherence Tomography Angiography Microvascular Metrics with Mild Cognitive Impairment in Patients with Non-Proliferative Diabetic Retinopathy: A Cross-Sectional Study. [Journal Article]Curr Eye Res. 2026 Aug 24; :1-13. [Online ahead of print]CE
- CONCLUSIONS: PCA-derived OCTA metrics may provide an interpretable approach for summarizing correlated vascular parameters and characterizing integrated microvascular alteration patterns related to MCI in NPDR. However, their limited adjusted discrimination requires further validation.
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- Tear Fluid: A Bridge Between Basic Biology and Modern Research Strategies. [Journal Article]Curr Eye Res. 2026 Aug 22; :1-2. [Online ahead of print]CE
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- Automated Versus Image-Guided Cyclotorsion Control in FS-LASIK: A Vector Analysis Study. [Journal Article]Curr Eye Res. 2026 Aug 19; :1-7. [Online ahead of print]CE
- CONCLUSIONS: Both automated and image-guided cyclotorsion control strategies produced excellent visual and refractive outcomes after FS-LASIK. However, image-guided manual alignment using the Callisto system was associated with superior uncorrected visual acuity and a more favorable vector profile, supporting its use as an effective alternative when automated cyclotorsion registration is limited.
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- Selective Intrinsically Photosensitive Retinal Ganglion Cells Ablation Regulates Myopia Development Through the Choroid/MAPK Pathway. [Journal Article]Curr Eye Res. 2026 Aug 17; :1-13. [Online ahead of print]CE
- CONCLUSIONS: Collectively, our results reveal that the ipRGCs mediates the effects of choroid/MAPK pathway on AL, providing a refined understanding of retinal mechanisms and identifying a potential therapeutic target for myopia.
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- Tear GDF15 Levels Are Elevated in Primary Open-Angle Glaucoma Patients and Correlate With Aqueous Humor Levels. [Journal Article]Curr Eye Res. 2026 Aug 17; :1-5. [Online ahead of print]CE
- CONCLUSIONS: Tear GDF15 is detectable and significantly elevated in POAG patients. Tear GDF15 correlates with AH GDF15 after normalization to total protein. These findings suggest the potential of tear GDF15 as a noninvasive molecular biomarker of POAG and highlight the importance of larger studies to validate these findings.
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- Ginkgo Biloba Standardized Extract EGb 761 Reduces Light and Toxin-Induced Photoreceptor Cell Damage via Regulating Oxidative Stress and Autophagy. [Journal Article]Curr Eye Res. 2026 Aug 12; :1-13. [Online ahead of print]CE
- CONCLUSIONS: EGb 761 exerts a protective effect on photoreceptor cell damage in retinal degeneration. This process was associated with a modification of the AMPK/ERK signaling pathway that regulates oxidative stress and autophagy.
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- Role of Circulating Immune Cells in Mediating the Effect of Gut Microbiota on Central Serous Chorioretinopathy: A Mendelian Randomization and Mediation Analysis. [Journal Article]Curr Eye Res. 2026 Aug 11; :1-12. [Online ahead of print]CE
- CONCLUSIONS: Our mediated mendelian randomization analysis provides genetic evidence suggesting that circulating immune cells may mediate the causal relationship between gut microbiota and CSCR. The identified associations and mediation effects offer new insights into potential therapeutic avenues for CSCR.
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- SGLT2i Canagliflozin Exerts Neuroprotection in Diabetic Retinopathy by Inhibiting Microglial Proinflammatory Cytokine Release by Downregulating the TLR4/NF-κB/NLRP3 Pathway. [Journal Article]Curr Eye Res. 2026 Aug 11; :1-13. [Online ahead of print]CE
- CONCLUSIONS: These findings identify CANA as a promising therapeutic candidate for DR, acting through TLR4/NF-κB/NLRP3-dependent modulation of microglial activation.
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