(Dig Dis[TA])
2,672 results
  • Perceived satisfaction of outpatients undergoing endoscopic examination: cross-sectional observational study. [Journal Article]
    Dig Dis. 2026 Aug 19; :1-24. [Online ahead of print]Grilli F, Lo Cascio A, … Napolitano DDD
  • Background Patient satisfaction is a key quality indicator in gastrointestinal endoscopy, influencing adherence, service improvement, and overall care experience.This study aimed to assess determinants of satisfaction among outpatients undergoing gastrointestinal endoscopic procedures. Methods We conducted a cross-sectional study at the Digestive Endoscopy Service of a university hospital in Ital…
  • Publisher Full Text (DOI)
  • Anxiety and Depression in Pancreatitis: Mechanisms, Assessment, and Treatment. [Review]
    Dig Dis. 2026 Aug 12; :1. [Online ahead of print]Xiong C, Zheng Z, … Ren YDD
  • CONCLUSIONS: Patients with pancreatitis commonly present with comorbid anxiety and depression, with chronic pancreatitis patients being more susceptible than those with acute pancreatitis. The mechanisms underlying this comorbidity are complex and likely multifactorial. Biological factors encompass inflammation-driven cytokine signalling to the brain, Hypothalamic-Pituitary-Adrenal (HPA) axis hyperactivity, gut microbiome dysbiosis, and altered central nervous system plasticity. Psychosocial factors include the emotional burden of pancreatitis, persistent sleep disturbances, substance abuse, and diminished family and social support. Assessment primarily relies on various types of scales, while treatment encompasses a comprehensive approach involving medication, psychological interventions, and family and social support.This paper reviews the epidemiological characteristics of anxiety and depression in patients with pancreatitis, explores their biological and psychosocial mechanisms, and summarizes key points for the assessment and treatment of this comorbidity.
  • Publisher Full Text (DOI)
  • IgE-Mediated Food Allergy in Patients with Celiac Disease. [Journal Article]
    Dig Dis. 2026 Jul 10; :1-12. [Online ahead of print]Magen E, Merzon E, … Israel ADD
  • CONCLUSIONS: CD is associated with an increased risk of IgE-mediated food allergies. Further studies are warranted to elucidate the immunopathological links and clinical implications of this association.
  • Publisher Full Text (DOI)
  • Consensus recommendations for the management of H. pylori in Egypt: 2026 report. [Practice Guideline]
    Dig Dis. 2026 Jul 07; :1-25. [Online ahead of print]Alboraie M, Elhossary W, … Esmat GDD
  • CONCLUSIONS: This 2026 Egyptian consensus provides practical guidance on optimizing H. pylori diagnosis and eradication. Key updates include support for high-dose PPIs and vonoprazan-based therapy, expanded use of bismuth regimens, and validation of high-dose dual therapy as an effective option. Adoption of these recommendations aims to improve eradication success, reduce complications, and guide future public health strategies in Egypt.
  • Publisher Full Text (DOI)
  • Pancreatitis in Familial Dysautonomia Patients. [Journal Article]
    Dig Dis. 2026 Jun 25; :1-7. [Online ahead of print]Benson AA, Cohen A, … Maayan CDD
  • CONCLUSIONS: There is a significantly increased risk for pancreatitis among FD patients that is not explained by traditional pancreatitis risk factors. This increased risk may be due to sphincter of Oddi dysfunction as part of their autonomic nervous system abnormalities.
  • PMC Free PDF
  • Endoscopic Submucosal Dissection-Associated Bacteremia: Proper Antibiotic Management. [Review]
    Dig Dis. 2026 Jun 16; :1-12. [Online ahead of print]Xia W, Chen Y, … Zhang SDD
  • CONCLUSIONS: This narrative review, based on a systematic search of PubMed, Embase, and the Cochrane Library through January 2026, analyzes the risk of bacteremia in ESD across different parts of the digestive tract and the necessity of antibiotic therapy, aiming to provide a reference for more in-depth exploration and clinical application.Current evidence indicates that the overall incidence of bacteremia after ESD is low (typically <5%), mostly transient, and rarely progresses to clinical infection.
  • Publisher Full Text (DOI)
  • The Investigation and Treatment of Helicobacter pylori for the Prevention of Gastric Cancer: A Narrative Review and Assessment of Management Approaches. [Review]
    Dig Dis. 2026 Jun 08; :1-11. [Online ahead of print]Costigan C, McNamara DDD
  • CONCLUSIONS: A test-and-treat approach (noninvasive H. pylori testing for symptomatic patients) towards young people has been advocated among European populations to date, and has been validated for improving symptoms of dyspepsia, and shown cost savings compared to symptomatic dyspepsia treatment alone. Randomised data on the reduction of gastric cancer since the introduction of this approach are lacking, but some retrospective studies show a clear cancer benefit to eradication. Several pilot studies in high-incidence countries have demonstrated cost-effective and real-world reductions in gastric cancer rates with population-based H. pylori screenings (screen-and-treat approach). Many of these countries have adopted national gastric cancer prevention strategies that incorporate H. pylori screening. Abundant modelling data in these countries show economic benefits to nearly all types of screening programmes; however, data in European populations, who have documented lower risks of both infection and progression to gastric cancer, are lacking. Modelled data suggest it may be feasible, but currently no guidelines recommend this approach. Currently, prospective European studies are underway to assess the practicality and cost-effectiveness of various methods of screening. We discuss the use of both endoscopy (test-scope-and-treat) and biomarkers as possible adjuncts to potential population-based screening to ensure maximum gastric cancer reduction from any such proposed approach.Prospective data from H. pylori high-incidence countries in Asia have shown a clear reduction in gastric cancer diagnoses after the introduction of population screening. Cost-effectiveness of population-wide screening is well documented in these countries and forms part of many national gastric cancer screening programmes. Modelled data from H. pylori low-incidence countries show population-based screening may be cost-effective, but real-world feasibility data are lacking.
  • Publisher Full Text (DOI)
  • Early-Onset Colorectal Cancer in Australia: Environmental, Microbial, and Policy Implications. [Review]
    Dig Dis. 2026 May 29; :1-7. [Online ahead of print]Gosavi R, Bell S, … Narasimhan VDD
  • CONCLUSIONS: Traditional risk factors such as obesity, metabolic syndrome, sedentary behaviour, alcohol, and smoking likely contribute through insulin resistance, chronic inflammation, and insulin-like growth factor 1-mediated signalling, but they do not fully explain the recent acceleration or distal predominance of EOCRC. Hereditary syndromes account for only a minority of cases, and tumour driver mutation patterns broadly resemble those of later-onset colorectal cancer, supporting earlier triggering rather than novel genetics. Emerging evidence implicates gut dysbiosis and exposures that disrupt mucosal defences or cause direct DNA damage. Colibactin-producing Escherichia coli may induce distinctive mutational signatures enriched in early and distal tumours. Microplastics and plasticisers may impair barrier function and promote low-grade inflammation, while per- and polyfluoroalkyl substances and related endocrine-disrupting chemicals are linked to metabolic and immune perturbation and altered bile acid biology. Antibiotic exposure, particularly early in life, may reduce microbial diversity and favour pathobionts. Inflammatory phenotypes, including inflammatory bowel disease, provide an additional model of inflammation-driven carcinogenesis relevant to EOCRC.EOCRC in Australia is a growing clinical and public health challenge that cannot be explained by inherited predisposition alone. A unifying exposome model may help integrate dietary, microbial, inflammatory, and environmental drivers of risk. Clinicians should promote earlier participation in the National Bowel Cancer Screening Program, including the 45-49 opt-in pathway, expedite investigation of rectal bleeding, altered bowel habit, and iron deficiency anaemia in younger adults, and embed lifestyle counselling into routine and survivorship care. Research priorities include prospective cohorts with early-life exposure data, integrated exposomics, microbiome profiling, and mutational signature analysis to clarify modifiable drivers and guide prevention.
  • PMC Free PDF