(Digestion[TA])
4,995 results
  • Incomplete Intestinal Metaplasia as a High-Risk Clinical Phenotype in Gastric Carcinogenesis: Implications for Surveillance and Management. [Review]
    Digestion. 2026 Aug 18; :1-34. [Online ahead of print]Wei H, Chen W, … Qiu SD
  • CONCLUSIONS: This review synthesizes current evidence on IIM as a high-risk transitional phenotype in gastric carcinogenesis. We detail its cellular origins, primarily from spasmolytic polypeptide-expressing metaplasia (SPEM) via chief cell reprogramming (paligenosis), and its characteristic hybrid molecular signature. Diagnostically, definitive subtyping relies on histochemical staining (e.g., AB-PAS), as conventional endoscopy and histology lack sufficient precision, highlighting a barrier to routine risk stratification. Epidemiologically, IIM is associated with a 4- to 11-fold increased risk of gastric cancer compared to CIM. While Helicobacter pylori eradication may induce partial regression, patients with IIM retain a significant residual cancer risk, necessitating ongoing surveillance. Emerging endoscopic techniques (e.g., narrow-band imaging) and molecular biomarkers (including DMBT1, AQP5, TROP2, and OLFM4) show promise for improving in vivo detection and risk assessment, with combinatorial biomarker strategies potentially better capturing IIM's hybrid phenotype. Current classification systems have limitations, including the frequent coexistence of subtypes and a lack of validated biomarkers for precise risk stratification.1、IIM is a biologically unstable, transitional lesion with a markedly elevated risk of progression to gastric adenocarcinoma, warranting its distinction from CIM in clinical practice. 2、 Reliance on specialized pathology for diagnosis limits widespread risk stratification, creating an urgent need for reliable endoscopic predictors and validated molecular biomarkers. 3、Even after successful H. pylori eradication, patients with IIM require long-term endoscopic surveillance due to persistent cancer risk. Future strategies must integrate IIM subtyping into personalized surveillance protocols to enhance gastric cancer prevention.
  • Retraction Statement. [Journal Article]
    Digestion. 2026 Jul 31; :1. [Online ahead of print]D
  • The article "Identification of LGR5 and TFF2 as Biomarkers in High-Risk Chronic Atrophic Gastritis: From Multi-Omics Mining to Clinical Validation" [Digestion. 2026; https://doi.org/10.1159/000549887] by Qingqing Zhang, Di Wu, Fengyun Guo, Shengnan Yang, Lijing Bao, Ruiying Zhang and Ping Wang has been retracted by the Publisher and the Editor.Post-publication concerns were raised regarding the i…
  • Directional Bias in Polyp Detection during Colonoscopy: A Prospective Observational Study. [Journal Article]
    Digestion. 2026 Jul 01; :1-11. [Online ahead of print]Katagiri A, Mizuno S, … Yoshida HD
  • CONCLUSIONS: Polyp detection during colonoscopic withdrawal demonstrates a consistent directional bias, with the ULD functioning as a region of relatively reduced detection frequency. Awareness of this intrinsic limitation and deliberate inspection of the ULD may help optimize visual inspection patterns during colonoscopy.
  • Comparative Effectiveness of Hangeshashinto and Ramosetron for the Treatment of Irritable Bowel Syndrome with Diarrhea. [Journal Article]
    Digestion. 2026 Jun 01; :1-11. [Online ahead of print]Nishida K, Hirata Y, … Nishikawa HD
  • CONCLUSIONS: In this exploratory real-world analysis, hangeshashinto showed short-term symptom improvement similar to ramosetron, and combination therapy was associated with lower follow-up symptom scores than ramosetron monotherapy in propensity score-adjusted analyses. However, given the retrospective design, small sample size, and inconsistent findings across analytical approaches, these results should be interpreted cautiously and warrant confirmation in larger prospective studies.