- Papillary Balloon Dilation Versus Sphincterotomy for Small Common Bile Duct Stones: Recurrence and Pneumobilia in a Retrospective Cohort. [Journal Article]
- CONCLUSIONS: In selected patients with CBDSs ≤10 mm, EPBD was associated with a lower long-term recurrence hazard than EST. No statistically significant between-group difference in ERCP-related adverse events was observed. In exploratory CT analyses, greater papillary sphincter disruption was associated with pneumobilia, and pneumobilia was associated with subsequent stone recurrence.
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- Animal Models of Slow-Transit Constipation: Current Progress, Limitations, and Future Perspectives. [Review]
- CONCLUSIONS: The Face-Construct-Predictive framework exposes the translational shortfall of current STC animal models and defines concrete design criteria for clinically relevant successors, guiding model selection and prioritizing future research.
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- Personality Traits Are Associated with Dietary Behaviors and Psychosocial Outcomes in Adolescents with Celiac Disease: A Cross-Sectional Study. [Journal Article]
- CONCLUSIONS: Higher openness may make a GFD feel more restrictive, lower conscientiousness may hinder GFD adherence planning, and higher neuroticism may increase anxiety and depression risk. Personality-informed counseling could help clinicians tailor support to improve adherence and well-being.
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- Gastric Intestinal Metaplasia After Helicobacter pylori Eradication: Reframing the Reversibility Controversy. [Review]
- CONCLUSIONS: GIM reversibility is a continuous function of lesion characteristics, host factors, time since eradication, intervention intensity, and oncogenic memory burden rather than a binary property. The clinically relevant question is whose GIM, under what conditions, over what time frame, and with what residual risk reduction. The frameworks are hypothesis-generating, not validated clinical recommendations; prospective validation of risk-stratified surveillance represents the most urgent research priority.
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- Efficacy of Tenapanor in Patients With or Without Prior Use of IBS-C Prescription Medications: A Post-hoc Analysis of Phase 3 Clinical Trials. [Journal Article]
- CONCLUSIONS: A clinically meaningful response to tenapanor was observed in adults with IBS-C regardless of prior IBS-C prescription medication use.
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- Zinc Transporter ZIP7 Is Associated with Intestinal Barrier Injury in Severe Acute Pancreatitis: Potential Roles in Mitochondrial Homeostasis and Ferroptosis. [Journal Article]
- CONCLUSIONS: ZIP7 inhibition ameliorates SAP‑induced IBI and modulates zinc metabolism, mitochondrial homeostasis, and ferroptosis in rats, suggesting that ZIP7 may represent a potential therapeutic target for SAP‑induced IBI.
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- Disparities in Osteopathic Representation Within Gastroenterology Fellowships. [Journal Article]
- CONCLUSIONS: Osteopathic physicians continue to remain underrepresented in gastroenterology fellowships nationwide. However, osteopathic representation at the fellow and leadership levels demonstrates a strong positive correlation, suggesting that leadership composition plays a meaningful role in fostering diversity within gastroenterology training programs.
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- Reflecting on Quality-of-Care Delivery in Inflammatory Bowel Disease Pregnancy: The (Pause and Reflect) PAUSA Study. [Journal Article]
- CONCLUSIONS: Uptake of guideline recommendations for antenatal IBD management was variable between different speciality providers in this study of patients with moderate-to-severe IBD. Uptake of recommendations may be improved by increasing access to multidisciplinary care and frequent clinical contact. Whether improvements in adherence with process indicators translates to improved clinical outcomes warrants further evaluation in IBD pregnancy.
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- Real-Time Computer-Aided Detection During Colonoscopy-Effects on Advanced, Diminutive, and Non-Neoplastic Lesion Detection: A Systematic Review and Meta-Analysis of Randomized Trials. [Journal Article]
- CONCLUSIONS: Real-time CADe increases overall ADR on average and increases non-neoplastic lesion detection, with moderate-certainty evidence suggesting increased diminutive adenoma detection. However, it did not demonstrate clear evidence of increased advanced adenoma, adenoma ≥ 10 mm, or advanced colorectal neoplasia detection. Higher ADR alone should not be assumed to represent greater detection of clinically consequential neoplasia.
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- Coded Gastrointestinal Diagnoses in Women Aged 18-44 Years with Iron Deficiency Anemia Without Selected Coded Alarm Features Who Underwent Same-Day Bidirectional Endoscopy: A Multicenter U.S. Electronic Health Record Study. [Journal Article]
- CONCLUSIONS: These coded diagnoses cannot be assumed to represent newly detected lesions or causes of IDA. Without a non-endoscoped comparison group, the study cannot establish the benefit of routine or selective endoscopy.
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- Suppression of TRIM33 and SMAD4 Indicates a Possible Tumor-Suppressive Role in Esophageal Squamous Cell Carcinoma. [Journal Article]
- CONCLUSIONS: Concurrent downregulation and positive correlation between TRIM33 and SMAD4 in ESCC may contribute to disease progression. TRIM33 and SMAD4 methylation were observed in ESCC, with SMAD4 methylation showing an association with advanced disease. However, further functional studies are warranted to confirm the clinical utility of our findings.
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- Rates of Aerodigestive Cancer After Positive mt-sDNA and Colonoscopy Without Advanced Colorectal Neoplasia in Patients with a Prior Cancer History. [Journal Article]
- CONCLUSIONS: In this cohort, approximately one in five patients were subsequently diagnosed with a new primary malignancy or recurrent disease; these findings require further study, do not support changes in clinical surveillance, and highlight the need for careful discussion when ordering mt-sDNA testing in patients with prior non-CRC.
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- Modulation of Pancreatic Activity by Ghrelin and Its Potential Effects on Acute Pancreatitis. [Review]
- Ghrelin is a brain-gut peptide primarily secreted by the gastric fundus, which exhibits a range of physiological functions, including stimulating growth hormone (GH) release, regulating energy metabolism, and modulating appetite. It is also expressed in pancreatic tissue and participates in the regulation of both endocrine and exocrine pancreatic functions. This article reviews the expression cha…
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- A Large Yellow Plaque with Xanthomatous Changes in Barrett's Esophagus. [Journal Article]
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