- Haidinger's brushes in albinism: altered perception patterns in single cases. [Journal Article]
- CONCLUSIONS: Individuals with albinism can perceive polarization-dependent entoptic phenomena, but the percept may be qualitatively altered. The findings suggest residual macular-pigment-related dichroism but do not isolate its retinal, corneal, or neural determinants. Quantitative studies with macular pigment optical density (MPOD) mapping, optical coherence tomography metrics of the Henle fiber layer (OCT-HFL), corneal polarimetry, and temporal-sensitivity testing are needed.
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- Photopic negative response (PhNR) of the full-field electroretinogram as a biomarker of retinal ganglion cell loss in glaucoma: a systematic review and meta-analysis. [Journal Article]
- CONCLUSIONS: PhNR amplitude is a sensitive, non-invasive electroretinographic biomarker of RGC loss in glaucoma, reduced proportionally to disease severity and IOP. These findings support incorporation of PhNR into glaucoma electrophysiological assessment protocols.
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- Electronegative ERG revealing melanoma-associated retinopathy in a patient with trametinib-associated retinopathy. [Journal Article]
- CONCLUSIONS: In patients with melanoma who develop MEKAR during trametinib therapy, persistent nyctalopia or other visual symptoms despite anatomical resolution should prompt evaluation for concomitant paraneoplastic retinopathy. An electronegative ffERG together with anti-TRPM1 autoantibody positivity can provide important supportive evidence for MAR.
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- The interaction between the ERG responses to sinusoidal modulation and flashes in mice. [Journal Article]
- CONCLUSIONS: The responses to flashes and modulating background influence each other in a complex manner. This is in contrast to responses in human observers, where only the flash response is influenced by the flash phase relative to the sinewave background. We propose that mouse responses are more sluggish and are integrated over extended periods, resulting in complex mutual interactions between responses to flashes and backgrounds.
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- Editorial (volume 153, issue 1): focus on clinical evaluation of vision. [Editorial]Doc Ophthalmol. 2026 Aug; 153(1):1.DO
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- Paroxysmal tonic upgaze mimicking epileptic seizures in infancy: a diagnostic challenge. [Journal Article]
- CONCLUSIONS: Recognition of PTU as a non-epileptic paroxysmal disorder is essential to avoid misdiagnosis of epilepsy and unnecessary therapeutic interventions.
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- Severe visual impairment as a complication of autism spectrum disorder. [Journal Article]
- CONCLUSIONS: Electrophysiological assessments, including ERG and (PVEP) were central to establishing an accurate diagnosis in cases where resolution of anterior segment lesions due to keratomalacia did not result in visual improvement. These tests are critical for the identification and monitoring of nutritional optic neuropathy.
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- Expanding the ocular and genetic spectrum of FLVCR1-associated disease in a Chinese cohort. [Journal Article]
- CONCLUSIONS: FLVCR1-associated disease can present as early-onset severe retinal degeneration (EOSRD), together with neurological involvement that may evolve over time. These findings refine phenotypic delineation, support multidisciplinary surveillance involving ophthalmology and neurology, and expand the known mutational spectrum of this rare disorder.
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- Assessment of full-field stimulus test results in Stargardt disease: correlations with full-field electroretinography, multifocal electroretinography, and optical coherence tomography. [Journal Article]
- CONCLUSIONS: FST is a simple, reliable and rapid test that can be applied in patients with low visual acuity. It effectively measures retinal sensitivity in patients with STGD. Given its practicality FST can be safely used to monitor the disease progression and treatment response in inherited retinal diseases.
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- Progressive cone dystrophy in PDE6C-associated achromatopsia with a likely pathogenic variant and a VUS. [Journal Article]
- CONCLUSIONS: This case expands the phenotypic spectrum of PDE6C-associated retinal disease by describing a severe cone dysfunction phenotype with clinical features consistent with achromatopsia. In the context of an autosomal recessive condition, the presence of a likely pathogenic variant alongside a variant of uncertain significance, combined with a consistent clinical and electrophysiologic phenotype, supports a possible biallelic disease mechanism. These findings contribute to emerging genotype-phenotype correlations and may aid in interpreting rare PDE6C variants.
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- Clinical and genetic spectrum of genetic eye diseases seen in two newly developed ophthalmic genetics clinics: two-year experience. [Journal Article]
- CONCLUSIONS: This study provides a comprehensive overview of the encountered GEDs spectrum. The data are valuable for refining clinical diagnoses, establishing accurate inheritance patterns, informing family planning, and assessing patient eligibility for emerging gene-targeted therapies.
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- Abstracts of the 63rd Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2026), Sydney, Australia. [Journal Article]Doc Ophthalmol. 2026 Jul 23. [Online ahead of print]DO
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- Electronegative ERG in association with probable TRPM1-related cancer associated retinopathy: a case report. [Journal Article]
- CONCLUSIONS: Electronegative ERGs are unusual in CAR, which usually affects photoreceptor function. This case, associated with anti-retinal autoantibodies to TRPM1, highlights the need for full systems review in a patient with possible paraneoplastic disease, even in the absence of systemic symptoms.
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- Selective i-wave attenuation in unilateral high myopia. [Journal Article]
- CONCLUSIONS: These findings suggest that, beyond genetic susceptibility and in the absence of overt unilateral ocular pathology, additional modulatory influences may contribute to the localized retinal regulatory mechanisms. Moreover, the i-wave appears to be a promising electrophysiological biomarker capable of detecting subtle alterations in retinal signaling, with potential implications for elucidating myopia pathogenesis and guiding targeted therapeutic development.
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