- A pilot randomized controlled trial assessing the feasibility and preliminary effects of a text message intervention to promote secure storage and disposal of prescription opioids. [Journal Article]Drug Alcohol Depend. 2026 Sep 25; 288:113366. [Online ahead of print]DA
- CONCLUSIONS: A theory-informed SMS intervention to promote opioid medication safety was feasible, acceptable, and associated with improved storage behaviors. Findings support further evaluation through a hybrid effectiveness-implementation trial.
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- Independent and interactive association of reported impairment in fatal crashes among young California drivers: A cross-sectional analysis. [Journal Article]Drug Alcohol Depend. 2026 Oct 02; 288:113380. [Online ahead of print]DA
- CONCLUSIONS: Reported substance-related impairment significantly increased fatal crash risk among California young drivers, with alcohol-drug co-use associated with synergistically elevated risks. Preventing polysubstance use presents an urgent opportunity for youth-focused interventions targeting risky driving behaviors among young drivers.
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- Combination bupropion-zonisamide facilitates rapid reduction in smoke exposure and prevents weight gain during switching to electronic nicotine delivery systems: A randomized clinical trial. [Journal Article]Drug Alcohol Depend. 2026 Oct 08; 288:113386. [Online ahead of print]DA
- CONCLUSIONS: Bupropion plus zonisamide shows promise for smoking reduction and cessation, particularly when medication adherence is maintained. Prevention of post-cessation weight gain may offer additional clinical and public health benefits. Larger trials with longer treatment duration are warranted.
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- Nicotine vaping and conventional tobacco product use among adults in the United States stratified by substance use disorder severity: A cross-sectional analysis. [Journal Article]Drug Alcohol Depend. 2026 Oct 02; 288:113384. [Online ahead of print]DA
- CONCLUSIONS: Overall tobacco product use including vaping increased with severity of SUD. Strategies to integrate tobacco cessation with SUD treatment should consider vaped and conventional tobacco products and tailoring cessation treatment for SUD severity.
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- Behavioral economic analysis of the reinforcing effects of fentanyl, cocaine, and mixtures of fentanyl and cocaine in rats. [Journal Article]Drug Alcohol Depend. 2026 Oct 01; 288:113382. [Online ahead of print]DA
- CONCLUSIONS: These findings suggest that interactions between the reinforcing effects of fentanyl and cocaine are additive in nature, however, it is unclear whether similar interactions would be observed under clinically relevant states, such as physical dependence on opioids or opioid withdrawal.
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- Sex differences in the associations between symptom severity, social cognition, and connectivity between default mode sub-networks in alcohol use disorder. [Journal Article]Drug Alcohol Depend. 2026 Sep 25; 288:113377. [Online ahead of print]DA
- CONCLUSIONS: This study provides evidence for possible network connectivity-based mechanisms underpinning social cognition alterations in males and females with AUD. Findings show significant sex differences in these potential vulnerabilities, emerging at mild-to-moderate symptom severity, suggesting sex-specific treatment considerations are warranted.
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- Declines in stimulant-involved overdose mortality occurred only with fentanyl co-involvement, United States, 2023-2024. [Journal Article]Drug Alcohol Depend. 2026 Aug 12; 288:113314. [Online ahead of print]DA
- CONCLUSIONS: The recent decline in stimulant-involved overdose mortality was confined to deaths with fentanyl co-involvement. Non-fentanyl opioid-involved mortality declined in both strata, but the overall decline was predominantly associated with deaths with fentanyl co-involvement. These findings underscore the importance of stratifying category-specific overdose mortality by fentanyl co-involvement.
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- Psychological distress, perceived psychological reward, and nicotine dependence among young people. [Journal Article]Drug Alcohol Depend. 2026 Sep 28; 288:113378. [Online ahead of print]DA
- CONCLUSIONS: Findings indicate cross-sectional associations among PD, PR of EC use, and nicotine dependence in young people. Addressing PD may be relevant to efforts to reduce nicotine dependence; longitudinal and experimental studies are needed to determine whether PD management influences dependence.
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- Daily polysubstance use associated with HIV, HCV, and non-fatal overdose among people who inject drugs: A latent class analysis using nationwide data. [Journal Article]
- CONCLUSIONS: This study identified four novel polysubstance-polyroute typologies and their unique relationships with non-fatal overdose, HIV, and HCV risk among a nationwide sample of PWID. Interventions to mitigate infectious disease and non-fatal overdose risk among PWID may benefit from tailoring responses based on the needs of specific drug use combinations that individuals use daily.
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- Coping patterns moderate the association between negative affect and potential proxies for hypersexual behavior in stimulant-using men who have sex with men. [Journal Article]Drug Alcohol Depend. 2026 Sep 20; 288:113369. [Online ahead of print]DA
- CONCLUSIONS: Negative affect and problem-focused and emotion-focused coping patterns may be important variables influencing hypersexual behavior among stimulant-using MSM, with each potentially being modifiable in terms of cognitive and behavioral intervention approaches.
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- Cannabis retail accessibility and adolescent use across a maturing market: Evidence from Canada. [Journal Article]Drug Alcohol Depend. 2026 Sep 20; 288:113368. [Online ahead of print]DA
- CONCLUSIONS: Spatial accessibility to cannabis retailers was associated with more frequent adolescent cannabis use early in the post-legalization period, but this relationship weakened as retail outlets became widespread. Policies focused on retailer proximity may have limited impact in mature retail markets.
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- PrEP stigma and early oral PrEP care continuum outcomes among people who inject drugs in Los Angeles and Denver. [Journal Article]Drug Alcohol Depend. 2026 Sep 19; 288:113371. [Online ahead of print]DA
- CONCLUSIONS: Stigma toward PrEP, reflected in negative beliefs and social attitudes about PrEP use, remains an important barrier to willingness to initiate PrEP among PWID. Interventions addressing PrEP-related stigma may improve PrEP engagement and help reduce HIV transmission risk among PWID.
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- Discrimination and early substance use among racial-ethnically minoritized youth: Self-reports and hair samples. [Journal Article]Drug Alcohol Depend. 2026 Sep 18; 288:113372. [Online ahead of print]DA
- CONCLUSIONS: This study underscores the unique influences of racial-ethnic and weight discrimination faced by racial-ethnically minoritized boys and girls, separately. Results highlight the need for programs and practices to address these unique experiences to effectively prevent early SU.
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- A multi-reward framework to improve translation in alcohol use disorder. [Review]Drug Alcohol Depend. 2026 Sep 19; 288:113373. [Online ahead of print]DA
- CONCLUSIONS: By offering a deeper understanding of past translational failures, this framework provides a basis for developing more valid and predictive preclinical models. Notably, identifying more effective pharmacological interventions will require improved alignment of the reward components controlling ethanol intake in animals and humans with AUD.
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- Prenatal care utilization among pregnant women with substance use disorder: A drug-free moms and babies program study. [Journal Article]Drug Alcohol Depend. 2026 Sep 23; 288:113370. [Online ahead of print]DA
- CONCLUSIONS: The study highlights the need to identify and address upstream factors that influence prenatal care engagement among rural pregnant women with SUD, particularly those using opioids and/or stimulants.
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