- Advances in Pectin-Based Bead Formation via Ionotropic Gelation for Enhanced Drug Delivery: A Scoping Review. [Review]Drug Dev Ind Pharm. 2026 Jul 23; :1-25. [Online ahead of print]DD
- CONCLUSIONS: Pectin beads produced via ionotropic gelation have demonstrated considerable potential for controlled and colon-targeted drug delivery. However, methodological variability and limited in vivo and clinical studies still limit their translation to pharmaceutical applications. Future research should focus on process standardization, Quality by Design approaches, and hybrid polymer systems.
- Publisher Full Text (DOI)
- Transformable Nanosystems for Cancer Treatment. [Review]Drug Dev Ind Pharm. 2026 Jul 22; :1-27. [Online ahead of print]DD
- CONCLUSIONS: Transformable nanosystems are promising next-generation platforms for cancer therapy; however, challenges related to safety, scalability, and clinical translation remain.
- Publisher Full Text (DOI)
- Harnessing the potential of spider silk proteins as emerging biomaterials for drug delivery: classification, comparative evaluation and future perspectives. [Review]Drug Dev Ind Pharm. 2026 Jul 22; :1-24. [Online ahead of print]DD
- ObjectiveThe objective of this review is to consolidate the role of native and recombinant spider silk in drug delivery systems. It aims to classify and compare their performance with natural and synthetic polymers, and emphasises their potential biomedical applications. It also evaluates the limitations and technical challenges, while offering perspectives on future directions to advance the cli…
- Publisher Full Text (DOI)
- A Review of Emerging Drug Delivery Strategies to Protect Cannabidiol from Chemical Degradation. [Review]Drug Dev Ind Pharm. 2026 Jul 21; :1-24. [Online ahead of print]DD
- CONCLUSIONS: The appropriate selection of CBD delivery systems is essential to ensure its chemical stability and to support the development of effective cannabinoid-based pharmaceuticals. Understanding the interplay between formulation design and storage conditions is crucial for optimizing CBD stability, extending shelf life, and ensuring the safety and efficacy of future CBD-containing therapeutic products.
- Publisher Full Text (DOI)
- Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: in vitro optimization and characterization. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 23; :1-23. [Online ahead of print]DD
- CONCLUSIONS: The engineered CAP-CEL-LIPs could be a promising platform for managing colon cancer.
- Publisher Full Text (DOI)
- An in vivo study on extended-release formulation of buprenorphine in Sprague-Dawley rats. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 16; :1-13. [Online ahead of print]DD
- CONCLUSIONS: According to the results, the plasma buprenorphine concentrations indicate sustained delivery of buprenorphine over a one-month period.
- Publisher Full Text (DOI)
- Rosuvastatin-Metformin Co-Processing: Enhanced Dissolution, Oral Bioavailability, and Therapeutic Efficacy through a Solvent-Minimized Approach. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 15; :1-26. [Online ahead of print]DD
- CONCLUSIONS: The co-processing of rosuvastatin with metformin presents a solvent-minimized and effective strategy to enhance the dissolution, bioavailability, and therapeutic efficacy of rosuvastatin. This approach holds promise for the clinical management of complex conditions such as dyslipidemia and type 2 diabetes mellitus.
- Publisher Full Text (DOI)
- Stimuli-responsive solid lipid nanoparticles for targeted drug delivery in biofilm-resistant infections: advances and challenges. [Review]Drug Dev Ind Pharm. 2026 Jul 21; :1-15. [Online ahead of print]DD
- CONCLUSIONS: Stimuli-responsive SLNs represent a promising strategy for overcoming biofilm resistance and enhancing antibiotic delivery. Although preclinical data are promising, addressing formulation challenges and improving scalability are essential for successful clinical translation. Further research on optimizing SLN design and understanding biofilm interactions will be critical for advancing SLN-based therapies for biofilm-associated infections.
- Publisher Full Text (DOI)
- Mitigating chemical degradation in amorphous and lipid-based formulations through cyclodextrin complexation and nanosizing. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 21; :1-15. [Online ahead of print]DD
- CONCLUSIONS: Although LBF and ASD improved PK exposure, chemical instability limited their suitability. Nanosizing and cyclodextrin complexation provided superior bioavailability enhancement with robust stability, highlighting the importance of simultaneously optimizing exposure and chemical stability during formulation development.
- Publisher Full Text (DOI)
- Rutin-enabled improved systemic exposure of doxorubicin via nanostructured lipid carriers: a proof of concept through novel LC-MS/MS analysis. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 18; :1-17. [Online ahead of print]DD
- CONCLUSIONS: Rutin-enabled NLCs significantly enhance the systemic exposure and therapeutic performance of DOX, validated through a novel simultaneous LC-MS/MS bio-analytical approach.
- Publisher Full Text (DOI)
- On-site microfluidic analysis of combined and individual drug effects on breast cancer spheroids. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 15; :1-14. [Online ahead of print]DD
- CONCLUSIONS: This microfluidic platform enhances physiological relevance and analytical efficiency in 3D tumor drug testing, representing a promising tool for preclinical chemotherapy evaluation.
- Publisher Full Text (DOI)
- Preparation and characterization of pre-nanoemulsions encapsulating multiple oil-soluble active substances. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 09; :1-13. [Online ahead of print]DD
- CONCLUSIONS: This universal PNEs system provides a simple, low-cost, and efficient solution for delivering lipophilic active ingredients. It addresses the key challenges of traditional NEs and offers significant potential for practical applications across various industries.
- Publisher Full Text (DOI)
- Synergistic anticancer potential of andrographolide and paclitaxel: a dose-reduction strategy to minimize toxicity and enhance therapeutic efficacy. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 03; :1-22. [Online ahead of print]DD
- CONCLUSIONS: Co-delivery of AG and PTX via targeted nanocarrier offers a promising dose reduction strategy to circumvent the dose limiting toxicity of PTX while maintaining/enhancing its anticancer efficacy. Further, the findings suggest a translational potential for AG as a chemosensitizer in combination therapy regimens.
- Publisher Full Text (DOI)
- Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy. [Journal Article]Drug Dev Ind Pharm. 2026 Jul 03; :1-18. [Online ahead of print]DD
- CONCLUSIONS: Fruit waste-derived ZnO NPs offer promising antimicrobial, antioxidant, anticancer, and wound healing properties.
- Publisher Full Text (DOI)
- Biocompatible and bio-orthogonal surface engineering of inorganic self-assembled nanocrystals for precision drug targeting: a review. [Review]Drug Dev Ind Pharm. 2026 Jun 27; :1-21. [Online ahead of print]DD
- CONCLUSIONS: We further address translational challenges including long-term biocompatibility, scalable manufacturing, and regulatory pathways, proposing design principles for next-generation nanotherapeutics where interfacial chemistry dictates biological destiny.
- Publisher Full Text (DOI)