- Clinical insights from diagnosis to outcomes in pediatric hypoparathyroidism and inactivating PTH/PTHrP signaling disorders. [Journal Article]Endocr Res. 2026 Jul 30; :1-10. [Online ahead of print]ER
- CONCLUSIONS: Pediatric HP and iPPSD show distinct profiles. Serum calcium levels increased during follow-up in the iPPSD and non-surgical HP groups, while postsurgical HP patients achieved normocalcemia more rapidly. In the iPPSD group, reductions in serum phosphorus and PTH levels suggested effective long-term biochemical control. Oral calcium supplementation decreased over time in iPPSD and non-surgical HP, whereas calcitriol doses remained stable, and no renal complications were observed, supporting the safety of current treatment strategies.
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- The interaction between eGDR and visceral adiposity in renal function decline among middle-aged and elderly diabetes patients: findings from a nationwide Chinese cohort. [Journal Article]Endocr Res. 2026 Aug; 51(3):142-153.ER
- CONCLUSIONS: High CVAI was observed to be related with rapid decline of renal function, while no significant relationship of eGDR, interaction, and rapid decline of renal function was observed. Low eGDR and high CVAI are negative associated with ΔeGFR, respectively. Notably, there exists multiplicative interaction betweenthem on ΔeGFR.
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- Impact of antithyroid drug duration on radioactive iodine therapy efficacy in Graves' disease in Japan: a propensity score-matched analysis using thyroid weight-based outcomes. [Journal Article]Endocr Res. 2026 Jul 09; :1-10. [Online ahead of print]ER
- CONCLUSIONS: These results suggest that prolonged ATD administration before RAIT is associated with reduced therapeutic efficacy, providing stronger evidence than prior observational reports.
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- MMRN1 suppresses thyroid cancer progression via activation of the Hippo signaling pathway. [Journal Article]Endocr Res. 2026 Aug; 51(3):178-192.ER
- CONCLUSIONS: MMRN1 acts as a tumor suppressor in TC by activating the Hippo pathway and modulating oxidative stress and ferroptosis. These findings highlight MMRN1 as a potential therapeutic target for TC treatment.
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- Body composition and cardiometabolic changes during gender-affirming hormone therapy: 12-month longitudinal study. [Journal Article]Endocr Res. 2026 Aug; 51(3):154-162.ER
- CONCLUSIONS: In transgender men without oophorectomy, testosterone therapy was associated with favorable changes in body composition alongside modest shifts in cardiometabolic indices over a 12-month period. These findings suggest that simple indices such as PAI and TyG may be useful for monitoring early cardiometabolic changes attributable to exogenous testosterone therapy. Larger prospective studies are warranted to confirm these observations.
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- Epigenetic analysis reveals aberrant aging in thyroid cancer. [Journal Article]Endocr Res. 2026 Aug; 51(3):163-177.ER
- CONCLUSIONS: Our findings provide valuable insights into the complex interplay between epigenetic regulation, immune dysfunction, and genomic instability in thyroid cancer, highlighting promising avenues for future research and therapeutic intervention.
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- AR gene functional domains and their role in clinical severity in androgen insensitivity syndrome: a single-center cohort from Turkey. [Journal Article]Endocr Res. 2026 Jun 12; :1-11. [Online ahead of print]ER
- CONCLUSIONS: This study expands the AR variant spectrum in AIS and represents one of the more comprehensively characterized cohorts from our country. While LBD variants were more often associated with severe phenotypes and NTD variants with milder presentations, marked phenotypic variability was observed. Nevertheless, considerable phenotypic variability, including marked intrafamilial heterogeneity, was evident. The T/DHT ratio provided supportive biochemical information but did not replace the need for molecular confirmation. Molecular confirmation remains essential, and multidisciplinary, patient-centered management is warranted.
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- Nocturnal tissue glycemia is associated with cortisol rise in the morning in young but not in older healthy adults. [Journal Article]Endocr Res. 2026 Aug; 51(3):133-141.ER
- Cortisol and vitamin D are known to influence plasma glucose, but their relationship with glycemia, assessed by continuous glucose monitoring, remains unclear for healthy adults. This study compared these relationships between 32 young (26.0 ± 4.8 years) and 25 older (67.3 ± 4.8 years) healthy volunteers. Cortisol was determined at bedtime, awakening, and 30 min (T30) and 60 min (T60) post-awaken…
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- Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes. [Journal Article]Endocr Res. 2026 May; 51(2):100-116.ER
- CONCLUSIONS: CCI induced broad, durable anti-inflammatory effects, supporting its role in lowering systemic inflammation and cardiometabolic risk.
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- Chemical chaperone TUDCA rescues Insulin-mediated vascular relaxation via ER stress inhibition in diabetic rat model. [Journal Article]Endocr Res. 2026 Aug; 51(3):119-132.ER
- Tauroursodeoxycholic acid (TUDCA) has been shown to improve endothelial dysfunction in type 2 diabetes mellitus (T2DM). However, its role in attenuating endothelial insulin resistance in diabetes is not well understood.
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- Correction. [Journal Article]
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- ETV4 transcriptionally activates STAT6 to inhibit ferroptosis and promote immune escape in thyroid cancer. [Journal Article]Endocr Res. 2026 May; 51(2):78-92.ER
- CONCLUSIONS: ETV4 transcriptionally activated STAT6 to inhibit ferroptosis and promote immune escape in THCA. Targeting the ETV4-STAT6 axis may offer a novel therapeutic strategy, potentially inhibiting ferroptosis and enhancing immune response in THCA patients.
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- Diabetic ketoacidosis and hyperosmolar hyperglycemic state in patients with end-stage renal disease on dialysis: a review. [Review]Endocr Res. 2026 May; 51(2):59-67.ER
- CONCLUSIONS: Treatment must be individualized. Emerging strategies, including extended dialysis sessions and closed-loop insulin delivery, require further validation.
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- Role of the trigeminal system in pancreatic innervation: new concept and challenge - a narrative review. [Review]Endocr Res. 2026 May; 51(2):68-77.ER
- The pancreas is innervated by a complex network including vagal, sympathetic, and spinal sensory pathways but recent studies suggest that the trigeminal system, known for its role in sensory perception, may also contribute to pancreatic innervation.
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- Risk of obstructive sleep apnea and diabetes in Korean adults. [Journal Article]Endocr Res. 2026 May; 51(2):93-99.ER
- CONCLUSIONS: People at high risk for OSA had a higher prevalence of diabetes than those who were not at risk. Given the increasing burden of diabetes and the potential association of OSA with other essential health conditions, further research is needed to evaluate the benefits of diabetes prevention or blood glucose testing in patients with OSA.
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