- "Acute-phase reactions to zoledronate in clinical practice: a prospective single center study of 1,150 patients." [Journal Article]
- CONCLUSIONS: This real-life study shows a high frequency of APR when symptoms are assessed shortly after ZOL infusion with mild symptoms systematically underestimated over time. First infusion, younger age, and lack of prior bisphosphonate exposure were the main risk factors identified. These findings support improving pre-infusion counseling in higher-risk patients to reduce anxiety and support long-term adherence to osteoporosis treatment.
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- Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians. [Journal Article]
- CONCLUSIONS: APOC1 rs4420638 and CXCL8 rs4073 seem to be associated with DN risk in Tunisian T2DM patients both individually and within multilocus genetic profiles.
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- Peripheral blood cell counts as correlates of insulin sensitivity in children and youth with type 1 diabetes: A retrospective study from western India. [Journal Article]
- CONCLUSIONS: The development of double diabetes may occur independent of obesity and the cellular patterns observed paralleled those reported in non-obese populations. Larger studies are warranted to confirm these findings and to identify population-specific cellular correlates of declining insulin sensitivity in T1DM.
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- Type 2 diabetes in BRICS countries from 1990 to 2023: burden, trends and complementary Mendelian randomization evidence. [Journal Article]
- CONCLUSIONS: T2D burden in BRICS countries is high, heterogeneous, and still increasing, highlighting the need for country-specific prevention and care strategies.
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- Deciphering the immune landscape of parathyroid carcinoma: implications for immunotherapeutic responsiveness. [Journal Article]
- CONCLUSIONS: Parathyroid carcinomas predominantly exhibit a PD-L1-independent immune-tolerant microenvironment, rich in CTLs and MDSCs. The results predict a limited benefit from single-agent PD-1/PD-L1 blockade and the need for myeloid-targeting and immune-priming multimodal strategies.
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- Association between candidate genes and FRAX scores in postmenopausal women. [Journal Article]
- CONCLUSIONS: In postmenopausal Italian women an appropriate combination of haplotypes/alleles at PTH and OPG genes is associated with high mean FRAX values. Long term studies would allow to assess if combining multi-locus genetic analyses with FRAX scores could empower physicians to tailor personalized preventive early strategies for osteoporosis.
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- Infectious complications following thyroid needle procedures: an underrecognized clinical challenge. [Review]
- Ultrasound-guided thyroid needle procedures, including fine-needle aspiration (FNA), percutaneous ethanol injection (PEI), and thermal ablation, are widely regarded as safe and effective. Infectious complications are exceptionally rare and may be underrecognized because their presentation can overlap with expected post-procedural inflammatory reactions or aseptic nodule rupture. We performed a fo…
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- Ultrasound-guided thermal ablation in patients affected by Graves' disease: a systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: U-GTA appears to induce biochemical remission in approximately two-thirds of selected patients with persistent or relapsed GD, with a favourable short-term safety profile and preservation of thyroid function in most cases. However, remission rates remain lower than those typically reported for definitive surgical treatment, and current evidence is limited to small, non-randomized studies with relatively short follow-up. Larger prospective comparative trials with standardized protocols are required to define the role of U-GTA within current management strategies for GD.
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- Incomplete male puberty: a new nosographic entity. [Review]
- CONCLUSIONS: A structured surveillance protocol combining early infancy hormonal screening during minipuberty, serial orchidometry throughout childhood, and targeted Sertoli cell stimulation tests can identify incomplete male puberty years before irreversible spermatogenic failure. Early recognition enables timely intervention and counselling.
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- Functional causes of low testosterone predominate in contemporary Australian endocrine referral practice: a two centre experience across 5 years. [Multicenter Study]
- CONCLUSIONS: Most men referred with low testosterone did not have structural hypothalamic-pituitary-testicular axis disease, supporting a clinical approach prioritising identification of metabolic and reversible contributors before testosterone therapy. Diagnostic completeness and adherence to guideline-recommended imaging vary, but testosterone prescribing generally aligns with current Endocrine Society of Australia (ESA) and Pharmaceutical Benefits Scheme (PBS) restrictions. These findings support the establishment of a dedicated andrology service integrating metabolic, reproductive, and psychological care to optimise assessment and outcomes in men with androgen deficiency.
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- Clinical management challenges of Cushing's disease associated with double pituitary adenomas: four cases and literature review. [Case Reports]
- CONCLUSIONS: DPAs involving a corticotroph component should be considered as a possible explanation for persistent hypercortisolism after TSS when the resected lesion is negative for ACTH and T-PIT. Multidisciplinary reassessment and repeat expert pituitary imaging review may help identify an additional lesion. The role of adjunctive molecular imaging remains preliminary.
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- Association of the combined triglyceride-glucose and frailty index with chronic kidney disease: evidence from two national cohort studies. [Journal Article]
- CONCLUSIONS: In two national datasets, higher TyGFI was associated with prevalent CKD in the cross-sectional analyses and with incident CKD in the longitudinal CHARLS analysis. TyGFI may serve as a compact epidemiological marker combining metabolic and frailty-related burden, although its predictive and clinical utility requires further validation.
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- Determinants of physicians' risk-benefit perceptions of adjuvant radioactive iodine for differentiated thyroid cancer. [Journal Article]
- CONCLUSIONS: This survey shows discrepancy between reported clinical practice and current consensus guidelines as well as variation in practice patterns in Spain regarding [[131]I]NaI treatment.
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- Twenty-four-month evaluation of the glycemia risk index in adults with type 1 diabetes using advanced hybrid closed-loop systems. [Journal Article]
- CONCLUSIONS: These findings suggest that GRI may serve as a useful, readily interpretable metric for predicting long-term glycemic outcomes and support its complementary role alongside TITR in clinical assessment.
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