- Beyond the classic ketogenic diet: A systematic review of alternative and adjunctive therapies for GLUT1 deficiency syndrome. [Review]Epilepsy Res. 2026 Sep 23; 228:107926. [Online ahead of print]ER
- CONCLUSIONS: While CKD remains the reference standard for GLUT1-DS management, selected alternative and adjunctive therapies may offer clinically meaningful benefit in specific clinical contexts. The current evidence base, however, is limited. These findings support cautious and individualized use of alternative therapeutic strategies while highlighting the need for larger prospective studies and standardized outcome measures to better define their role in GLUT1-DS management.
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- Comparison of amyloid-β, total tau and phospho-tau in clinical AD patients with and without epileptiform EEG patterns. [Journal Article]Epilepsy Res. 2026 Sep 21; 228:107921. [Online ahead of print]ER
- CONCLUSIONS: Our bivariate analyses revealed the unexpected observation that the presence of IEDs was associated with lower rather than higher phospho-tau levels in clinical AD patients. This finding awaits further confirmation in a larger cohort.
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- Feasibility, safety and preliminary effectiveness of an epilepsy treatment smartphone application in rural primary care: A two-arm prospective observational study from India. [Journal Article]Epilepsy Res. 2026 Sep 19; 228:107922. [Online ahead of print]ER
- CONCLUSIONS: The ETA was feasible to deploy in routine rural primary care and was not associated with inferior diagnostic or treatment outcomes compared with epilepsy-trained care alone. These preliminary findings support further evaluation of the ETA as a tool to reduce the epilepsy treatment gap in resource-limited settings.
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- Losartan's regulation of PI3K/AKT signaling underlies its combined anti-seizure and antidepressant effects in epileptic rats. [Journal Article]Epilepsy Res. 2026 Sep 16; 228:107909. [Online ahead of print]ER
- CONCLUSIONS: Losartan may attenuate both seizures and depression-like behaviors in epileptic rats by activating the hippocampal PI3K/AKT signaling pathway and inhibiting neuronal apoptosis. These results highlight its potential as an adjunctive therapy for epilepsy with comorbid depression.
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- Epilepsy-associated labor force exclusion in a multi-ethnic neurology cohort. [Journal Article]Epilepsy Res. 2026 Sep 16; 228:107920. [Online ahead of print]ER
- CONCLUSIONS: In this single-center specialty-neurology cohort, epilepsy was associated with lower documented employment and higher recorded unemployment or disability than a contemporaneous comparator with other neurological conditions. These cross-sectional findings should be interpreted in the context of a clinically selected referral population and unmeasured neurological, functional, occupational, and socioeconomic factors.
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- Mapping the evidence-practice gap in pediatric post-traumatic seizures and post-traumatic epilepsy: A national practice-pattern survey of pediatric neurologists. [Journal Article]Epilepsy Res. 2026 Sep 08; 228:107903. [Online ahead of print]ER
- CONCLUSIONS: Pediatric PTS/PTE management in Türkiye shows strong convergence in drug selection but substantial variation in duration and follow-up decisions, reflecting persistent pediatric evidence gaps and highlighting the need for pediatric-specific guidelines and national consensus initiatives.
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- Risk of ECG abnormalities and arrhythmias in people with post-traumatic epilepsy. [Journal Article]Epilepsy Res. 2026 Sep 06; 228:107908. [Online ahead of print]ER
- CONCLUSIONS: Results indicate the high risk of ECG abnormalities and arrhythmias in PTE. While PTE is principally a neurological disorder, it is important to take a multi-system approach that includes cardiac monitoring.
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- Hyperphosphorylated tau pathology in patients with epilepsy and dementia - Neuropathological insights from a historical autopsy cohort. [Journal Article]Epilepsy Res. 2026 Sep 04; 228:107910. [Online ahead of print]ER
- CONCLUSIONS: In this cohort, dementia epileptica was associated with increased pTau burden in the epileptogenic hemisphere and time since diagnosis supporting the concept of seizure-induced pTau accumulation. However, pTau is unlikely to be the primary neuropathological link between epilepsy and dementia in the cohort studied given the overall mild pathology and competing diagnoses.
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- Association of tobacco use with seizures, psychosocial comorbidities, and quality of life among people with epilepsy: A cross-sectional analysis. [Journal Article]Epilepsy Res. 2026 Sep 02; 228:107905. [Online ahead of print]ER
- CONCLUSIONS: Tobacco use was significantly associated with medicinal cannabis which in turn was associated with increased seizure frequency among PWE. Given the risks associated with using multiple substances, more research is needed to better understand the association between epilepsy and multiple product use. These results underscore the need for integrating cessation-related resources into epilepsy clinics and self-management programs.
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- Alterations in serum zinc, copper, and selenium levels in children with drug-resistant epilepsy: A systematic review and meta-analysis. [Review]Epilepsy Res. 2026 Sep 03; 228:107904. [Online ahead of print]ER
- CONCLUSIONS: Children with DRE exhibit significantly lower serum zinc and selenium levels, while association with copper levels remains inconsistent. Larger randomized controlled trials are needed to determine causality and evaluate the potential role of trace element supplementation in DRE.
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- Dissociating decision-making deficits in temporal and frontal lobe epilepsy using Bayesian methods. [Journal Article]Epilepsy Res. 2026 Sep 02; 228:107906. [Online ahead of print]ER
- CONCLUSIONS: Focal epilepsy impacts decision-making efficiency in a manner contingent upon seizure focus. The observed distinctions between temporal groups tentatively suggest potential avenues for future longitudinal research into tailored neuropsychological interventions. These findings highlight the utility of Bayesian frameworks in providing a nuanced, probabilistic characterization of cognitive deficits in small sample sizes.
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- Plasma levels of glial fibrillary acidic protein and placental growth factor are associated with drug resistance in adult patients with newly diagnosed epilepsy. [Journal Article]Epilepsy Res. 2026 Sep 01; 227:107907. [Online ahead of print]ER
- CONCLUSIONS: Our findings suggest plasma GFAP and PGF may be associated with drug resistance in adult patients with newly diagnosed epilepsy.
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- Corpus callosotomy in Lennox-Gastaut syndrome: Effectiveness, safety, and predictors of outcome: A systematic review and meta-analysis. [Review]Epilepsy Res. 2026 Aug 26; 227:107902. [Online ahead of print]ER
- CONCLUSIONS: CC achieves ≥ 50% seizure reduction in ~70% of LGS patients. Outcomes were not influenced by surgical extent or approach. Evidence is limited to observational studies with very low certainty, highlighting the need for prospective, standardized, multicenter data.
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- Risk factors for adverse maternal‑neonatal outcomes in pregnant women with epilepsy and the impact of different anti-seizure medications exposures on neonatal birth weight. [Journal Article]Epilepsy Res. 2026 Aug 20; 227:107899. [Online ahead of print]ER
- CONCLUSIONS: Uncontrolled epilepsy before and during pregnancy, polytherapy, focal epilepsy, and gestational hypertension are independent risk factors for adverse maternal‑neonatal outcomes in pregnant women with epilepsy. Different ASMs have differential effects on neonatal birth weight; valproate and polytherapy are associated with significantly lower birth weight. Physicians should counsel women with epilepsy that achieving at least six months of seizure freedom before conception is associated with improved maternal-neonatal outcomes. Lamotrigine or levetiracetam monotherapy should be prioritized whenever possible, and close monitoring should be maintained throughout pregnancy.
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- Impact of pediatric epilepsy surgery on healthcare resource use. [Journal Article]Epilepsy Res. 2026 Aug 19; 227:107901. [Online ahead of print]ER
- CONCLUSIONS: Among pediatric patients with drug-resistant epilepsy, healthcare resource use substantially decreases after epilepsy surgery, especially when the patient does not require subsequent epilepsy surgeries. Results were similar for all types of insurance, for all races, and for all ethnicities.
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