- Contralateral piriform cortex alterations after surgery for temporal lobe epilepsy: A pilot MRI volumetry study. [Journal Article]Epilepsy Res. 2026 Oct 17; 228:107937. [Online ahead of print]ER
- CONCLUSIONS: In this hypothesis-generating pilot cohort, contralateral PCA volume decreased after epilepsy surgery, whereas the PASL-derived signal-intensity measure did not show a corresponding group-level change. These observations do not establish a surgery-induced network mechanism and require confirmation in larger controlled longitudinal cohorts.
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- Efficacy of Lactobacillus reuteri as an adjunctive therapy for seizure control and quality of life in pediatric drug-resistant epilepsy: A prospective interventional study. [Journal Article]Epilepsy Res. 2026 Oct 15; 228:107936. [Online ahead of print]ER
- CONCLUSIONS: In this single-arm before-after study, statistically significant within-participant changes in HRQOL and seizure frequency were observed during the 12-week period following adjunctive L. reuteri supplementation. However, the absolute magnitude of these changes was modest and their clinical significance remains uncertain. Because there was no concurrent placebo control group, the observed changes cannot be attributed specifically to L. reuteri supplementation. Larger, adequately powered placebo-controlled randomized trials are needed to determine whether L. reuteri provides a clinically meaningful benefit in pediatric drug-resistant epilepsy.
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- Does delayed removal of stereo-EEG electrodes following radiofrequency thermocoagulation increase haemorrhage? [Journal Article]Epilepsy Res. 2026 Oct 14; 228:107932. [Online ahead of print]ER
- CONCLUSIONS: Delayed removal of electrodes post-RF-TC allows assessment of response to RFA and the opportunity for further thermocoagulation if necessary. This exploratory study found no significant increase in haemorrhage volume with delayed electrode removal following RF-TC but a larger study would be required to definitively estimate haemorrhage risk.
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- Indoor environmental conditions and interictal epileptiform discharge frequency during pediatric video-EEG monitoring. [Journal Article]Epilepsy Res. 2026 Oct 06; 228:107930. [Online ahead of print]ER
- CONCLUSIONS: Pediatric epilepsy patients exhibit marked, highly individualized bidirectional sensitivities to ambient temperature and humidity despite a uniform group-level circadian rhythm in cortical excitability. These findings underscore the importance of personalized environmental monitoring in epilepsy management.
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- Response to: "Early benzodiazepine treatment and electrographic seizures after febrile status epilepticus". [Letter]Epilepsy Res. 2026 Oct 06; :107931. [Online ahead of print]ER
- We appreciate Inui et al.'s comments regarding the divergent prognostic outcomes of patients with electrographic seizures (ESz) between our studies. The poorer prognosis in their cohort compared to ours likely stems from three key differences. First, baseline disease severity significantly differed. Our cohort predominantly consisted of milder cases, such as febrile seizures, with only 17.2% requ…
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- Cross-cultural adaptation and hospital-based validation of Sinhala and Tamil versions of the AIIMS-modified INCLEN epilepsy screening questionnaire in Sri Lankan children and adolescents. [Journal Article]Epilepsy Res. 2026 Sep 27; 228:107927. [Online ahead of print]ER
- CONCLUSIONS: The Sinhala and Tamil versions of the AIIMS-modified INCLEN epilepsy screening questionnaire demonstrated acceptable diagnostic accuracy and high reliability of the derived classification variable in this hospital-based validation sample. The questionnaire may support structured identification of children requiring further diagnostic assessment but should not replace clinical evaluation. Prospective community-based validation using consecutive recruitment is required before routine implementation in primary care or population screening programmes.
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- Impact of Ramadan on seizure-related emergency department visits in Qatar. [Journal Article]Epilepsy Res. 2026 Sep 29; 228:107929. [Online ahead of print]ER
- CONCLUSIONS: Ramadan was not associated with increased seizure-related ED burden. Emergency physicians modified acute management for fasting subjects by favouring intravenous antiseizure medication loading and deferring new oral regimen initiation.
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- Reduced-lead electroencephalography performed at the discretion of emergency physicians in pediatric cases of altered mental status: A retrospective observational study. [Journal Article]Epilepsy Res. 2026 Sep 26; 228:107928. [Online ahead of print]ER
- CONCLUSIONS: Reduced-lead EEG can be effectively performed by ED physicians and may be a useful tool to facilitate timely intervention for ESz. However, we were unable to determine whether the intervention for ESz in the hyperacute phase of the ED contributed to improved outcomes.
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- Letter to the editor: A critical appraisal of 'principal component analysis of antiseizure medication-induced hostility/aggression and factor analysis of levetiracetam. [Letter]Epilepsy Res. 2026 Jun 24; :107859. [Online ahead of print]ER
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- Antiseizure medications in children with acute symptomatic seizures: A quality improvement project. [Journal Article]Epilepsy Res. 2026 Sep 26; 228:107925. [Online ahead of print]ER
- CONCLUSIONS: The implementation of a weaning protocol through our QI project contributed to a reduction in the duration of ASM use among children with ASyS admitted to our hospital without considerable impact on seizure outcomes.
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- Programming parameters affecting seizure reduction in responsive neurostimulation patients at a pediatric center. [Journal Article]Epilepsy Res. 2026 Sep 25; 228:107923. [Online ahead of print]ER
- CONCLUSIONS: Divergent programming strategies in cortical and thalamic RNS targets result in similar efficacy. Both were effective across differing seizure etiologies and types. These findings support the use of structured, individualized programming protocols in pediatric epilepsy care.
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- Intrathecal dexamethasone in FIRES. [Review]Epilepsy Res. 2026 Sep 23; 228:107924. [Online ahead of print]ER
- CONCLUSIONS: IT-DEX may represent a promising therapeutic option for FIRES, particularly in children and adolescents. Our findings provide preliminary evidence supporting its potential use, with administration at 72-hour intervals to a cumulative dose of 1 mg/kg emerging as a potentially reasonable approach. However, further studies are required to determine its optimal dosing, safety and efficacy.
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- Beyond the classic ketogenic diet: A systematic review of alternative and adjunctive therapies for GLUT1 deficiency syndrome. [Review]Epilepsy Res. 2026 Sep 23; 228:107926. [Online ahead of print]ER
- CONCLUSIONS: While CKD remains the reference standard for GLUT1-DS management, selected alternative and adjunctive therapies may offer clinically meaningful benefit in specific clinical contexts. The current evidence base, however, is limited. These findings support cautious and individualized use of alternative therapeutic strategies while highlighting the need for larger prospective studies and standardized outcome measures to better define their role in GLUT1-DS management.
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- Comparison of amyloid-β, total tau and phospho-tau in clinical AD patients with and without epileptiform EEG patterns. [Journal Article]Epilepsy Res. 2026 Sep 21; 228:107921. [Online ahead of print]ER
- CONCLUSIONS: Our bivariate analyses revealed the unexpected observation that the presence of IEDs was associated with lower rather than higher phospho-tau levels in clinical AD patients. This finding awaits further confirmation in a larger cohort.
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- Feasibility, safety and preliminary effectiveness of an epilepsy treatment smartphone application in rural primary care: A two-arm prospective observational study from India. [Journal Article]Epilepsy Res. 2026 Sep 19; 228:107922. [Online ahead of print]ER
- CONCLUSIONS: The ETA was feasible to deploy in routine rural primary care and was not associated with inferior diagnostic or treatment outcomes compared with epilepsy-trained care alone. These preliminary findings support further evaluation of the ETA as a tool to reduce the epilepsy treatment gap in resource-limited settings.
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