- Improving outcomes in the management of acute external laryngotracheal trauma. [Journal Article]
- CONCLUSIONS: Early intervention remains pivotal for successful management of laryngotracheal trauma. This single institutional study, characterized primarily by early definitive management by an experienced team; was able to achieve favourable outcomes even with the use of simple, readily available, inexpensive materials like - absorbable sutures for mucosal and cartilage approximation, and modified endotracheal tube as stents.
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- Serum IL-4, IL-5, IL-13 and sIgE are associated with short-term loss of disease control in allergic rhinitis: a real-world decision-tree model. [Journal Article]
- CONCLUSIONS: Baseline serum IL-4, IL-5, IL-13, sIgE, and eosinophil count were associated with loss of disease control within 6 months in adults with AR receiving routine pharmacotherapy. The decision-tree model provided an interpretable but preliminary representation of biomarker-based risk stratification. Given the retrospective single-center design and lack of external validation, these findings should be regarded as hypothesis-generating. Prospective multicenter studies and independent external validation are required before clinical implementation. This model pertains to routine pharmacotherapy and was not designed to evaluate outcomes after allergen immunotherapy or nasal surgery.
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- Serum Prestin and Ribeye levels in children with congenital profound sensorineural hearing loss. [Journal Article]
- CONCLUSIONS: Children with congenital profound SNHL exhibited higher serum levels of Prestin and Ribeye than normal-hearing controls. While both biomarkers showed potential, their performance may not yet be sufficient to support their use as standalone clinical tests. Further longitudinal studies with age-matched controls and direct biological validation are required to determine whether these circulating proteins could complement existing audiological assessments of congenital hearing loss.
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- From surgical response to treatment adequacy in adult obstructive sleep apnoea: a further response. [Letter]Eur Arch Otorhinolaryngol. 2026 Oct 31. [Online ahead of print]EA
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- Sleep architecture disruption and coordinated patterns of inflammatory and extracellular matrix biomarkers in obstructive sleep apnea: a cross-sectional study. [Journal Article]
- CONCLUSIONS: OSA severity is associated with coordinated patterns among inflammatory and ECM-related biomarkers that parallel hypoxic burden and sleep architecture changes. In contrast, systemic oxidative stress markers appear less integrated within these patterns. These findings support the potential utility of multi-biomarker approaches in reflecting disease-related physiological alterations, potentially arising from both systemic and local upper airway tissue processes.
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- Quality of life, psychological well-being, and socioeconomic burden in survivors of total laryngectomy: A mixed-methods study from LMIC setting. [Journal Article]
- CONCLUSIONS: Survivors of total laryngectomy demonstrated relatively preserved quality of life and low psychological distress despite substantial changes in employment and financial status. The observed discordance between structural survivorship burden and perceived well-being may reflect differences in individual adaptation and social context, but these should be considered possible explanations rather than established mechanisms.
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- Operating-room polidocanol sclerotherapy for HHT-related epistaxis. [Journal Article]
- CONCLUSIONS: Operating room endonasal polidocanol sclerotherapy was associated with clinically meaningful reduction in epistaxis burden, high patient acceptance, and a favourable safety profile. This approach may represent a valuable option for selected patients with recurrent HHT-related epistaxis requiring structured management beyond an office-based setting.
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- Prolonged hospitalization following head and neck cancer surgery: risk factors, clinical outcomes, and strategies for care optimization. [Journal Article]
- CONCLUSIONS: Prolonged hospitalization after HNC surgery is associated with adverse oncologic outcomes which may reflect underlying disease severity, and is primarily driven by postoperative complications, particularly flap-related complications, the most important and modifiable determinant of prolonged LOS.
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- Clinical characteristics, management, and long-term outcomes of nasopharyngeal osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma: a single-institution experience. [Journal Article]
- CONCLUSIONS: Nasopharyngeal ORN after radiotherapy for NPC is a rare but clinically significant entity. Endoscopic debridement may be considered when clinically indicated, and selective NSF reconstruction may represent a feasible reconstructive option in appropriately selected patients. This single-institution experience adds long-term outcome data that may help guide diagnosis, treatment planning, and surveillance in affected patients.
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- Epidemiology of oropharyngeal carcinoma in Europe: human papilloma virus contribution, incidence and mortality rates. [Journal Article]
- CONCLUSIONS: OPC incidence continues to rise across Europe, with significant inter-country differences and a growing role of HPV. These findings underscore the need for country-specific policies of expanded HPV vaccination, enhanced surveillance, and age-adapted preventive strategies to mitigate the rising OPC burden.
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- Influence of the COVID-19 pandemic on the incidence, severity, and pathogen spectrum of acute otitis media with complications in adults. [Journal Article]
- CONCLUSIONS: Our data showed a significant increase in AOM with complications following the lifting of COVID-19 isolation measures compared to pre-pandemic numbers with a shift towards more severe complications.
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