- Building a Better Model for Fecal Calprotectin Monitoring in IBD: Room for Some Home Improvement. [Editorial]Gastroenterology. 2026 Oct 16. [Online ahead of print]G
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- Prevalence of functional constipation and its associated factors among adults in Dar es Salaam, Tanzania: a population-based cross-sectional study. [Journal Article]
- CONCLUSIONS: The prevalence of constipation was relatively high in the general adult population in Temeke. Participants with old age and past cigarette smoking history were more likely to suffer from constipation while higher fluid intake was associated with lower odds of functional constipation.
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- Log-transformed systemic inflammation response index improves prediction of 28-day ICU mortality in critically ill patients with cirrhosis and atrial fibrillation: development in MIMIC-IV and external validation in eICU-CRD. [Journal Article]
- CONCLUSIONS: Log-SIRI was associated with 28-day ICU mortality after adjustment for age, sex, SOFA, and MELD-Na. The improvement in AUC over the base clinical model was modest but statistically significant, corroborated by concordant improvements in likelihood ratio, continuous NRI, and calibration. Prospective external calibration is needed before individual clinical use.
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- Procalcitonin for diagnosing infected pancreatic necrosis: a systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: PCT shows good overall ability to identify IPN and may be incorporated as an adjunctive biomarker for IPN risk stratification. A cutoff range of 1.0-3.5 ng/mL and serial monitoring may help clinical risk stratification. These cutoff-related findings require external validation in prospective multicenter studies with pre-specified cutoffs and standardized adjudicated reference criteria integrating clinical, radiologic, microbiologic, and procedural evidence, with culture confirmation incorporated when drainage or necrosectomy is clinically performed.
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- Knowledge levels of physiotherapy students on celiac disease: an exploratory cross-sectional study. [Journal Article]
- CONCLUSIONS: The findings should be interpreted cautiously but may support considering disease-specific educational content within multidisciplinary physiotherapy training.
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- Risk-Adapted Endoscopic Follow-Up After Achalasia: A Clinical Consideration. [Letter]Gastroenterology. 2026 Oct 15. [Online ahead of print]G
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- Reply to "Risk-Adapted Endoscopic Follow-Up After Achalasia: A Clinical Consideration". [Letter]Gastroenterology. 2026 Oct 15. [Online ahead of print]G
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- Platelet P2Y12 inhibitor use and risk of colorectal cancer incidence and colorectal cancer-related mortality: a Swedish registry-based cohort study. [Journal Article]
- CONCLUSIONS: P2Y12 inhibitor use was not associated with risk of incident CRC but was significantly inversely associated with CRC mortality, which appeared to be due to improved survival among individuals who initiate P2Y12 inhibitors after CRC diagnosis. These findings merit further study given the observational nature of the analysis and potential for residual confounding.
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- Myofibroblast Derived Transglutaminase 2 Activity is Upregulated in Stricturing Crohn's Disease and its Inhibition Exerts Anti-Fibrotic Properties. [Journal Article]Gastroenterology. 2026 Oct 13. [Online ahead of print]G
- CONCLUSIONS: TG2 may be involved in inflammation-independent progression of intestinal fibrosis.
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- HtpG-High-Expressing Escherichia coli Promotes Fibrosis in Chronic Pancreatitis. [Journal Article]Gastroenterology. 2026 Oct 13. [Online ahead of print]G
- CONCLUSIONS: These findings provide novel evidence for a pathogenic HHEC-HtpG-macrophage axis in CP, highlighting the potential of microbiota-targeted therapies for the condition.
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- Successful Engraftment Without Relief: Closing the Chapter on Fecal Microbiota Transplantation in IBS? [Journal Article]Gastroenterology. 2026 Oct 10. [Online ahead of print]G
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- Cost-effectiveness analysis of durvalumab combined with tremelimumab versus sorafenib as first-line treatment for unresectable Hepatocellular carcinoma in China: a dual-model approach utilizing partitioned survival and markov models. [Journal Article]
- CONCLUSIONS: Under current pricing, the STRIDE regimen is not cost-effective as a first-line treatment for unresectable HCC in China. While price concessions improve affordability, exploration of value-based pricing and future biomarker-guided patient stratification could be evaluated to optimize economic viability. The dual-model concordance reinforces the robustness of these findings.
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- EUS-guided and US-guided percutaneous splenic biopsy: a systematic review and meta-analysis of separately pooled diagnostic and safety outcomes. [Systematic Review]
- CONCLUSIONS: EUS-guided splenic biopsy and US-guided percutaneous splenic biopsy both appear diagnostically effective and generally safe in separately pooled analyses. Because no direct comparative studies were available, the findings should not be interpreted as evidence of superiority of either technique. US-guided percutaneous splenic biopsy may be considered for accessible lesions, whereas EUS-guided splenic biopsy may be considered in selected patients when percutaneous biopsy is contraindicated, technically difficult, or previously inconclusive. The formal study-level comparison remains unadjusted and indirect and does not establish superiority or inferiority.
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- Temporal trends and demographic disparities in mortality with co-mention of chronic liver disease and pneumonia in the United States, 1999-2024. [Journal Article]
- CONCLUSIONS: Mortality with co-mention of chronic liver disease and pneumonia rose sharply during the COVID-19 pandemic and remained persistently elevated through 2024; this pattern was similar in sensitivity analyses excluding deaths with a co-listed U07.1 code and using alternative case definitions. Substantial and sustained disparities were observed, particularly among non-Hispanic American Indian/Alaska Native individuals and non-metropolitan residents. These findings reflect co-occurrence on death certificates rather than a confirmed causal relationship, and highlight priority populations for continued surveillance and targeted public health efforts.
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- HLA-DRB1*01:03 is a Reproducible Biomarker of Colectomy Risk in Ulcerative Colitis. [Journal Article]Gastroenterology. 2026 Oct 08. [Online ahead of print]G
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