- Sex differences in the biomechanics and contractility of intramural coronary arteries in angiotensin II-induced hypertension. [Journal Article]
- CONCLUSIONS: The early steps of angiotensin II-dependent hypertension evoked very different adaptation mechanisms in males and females.
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- Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS. [Journal Article]
- CONCLUSIONS: Sex is an important factor in disease progression and the response of SOD1 mice to a drug targeting a central enzyme in nitrogen metabolism, with female sex hormones playing a greater role than male sex hormones. Glutamine synthetase, or its reactants and products, therefore plays a role in this disease, and the sex specificity of treatments aimed at this or other metabolic targets may therefore be an important factor in the development of therapies to treat amyotrophic lateral sclerosis.
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- Gender differences in Latin-American patients with rheumatoid arthritis. [Systematic Review]
- CONCLUSIONS: RA in LAC women is not only more common but presents with some clinical characteristics that differ from RA presentation in men. Some of those characteristics could explain the high rates of disability and worse prognosis observed in women with RA in LAC.
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- Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladder. [Multicenter Study]
- CONCLUSIONS: After RC for UCB, cancer-specific mortality was higher in female patients; this disadvantage was more pronounced in earlier time periods. In addition, worse outcome of women with verified LVI was shown to be comparable with men. These findings were suggestive of different tumor biology and potentially unequal access to timely RC in earlier time periods because of reduced awareness of UCB in women. Further studies are required to improve UCB outcome in both sexes, notably in female patients.
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- Newborns of preeclamptic women show evidence of sex-specific disparity in fetal growth. [Journal Article]
- CONCLUSIONS: Fetal growth was more impaired among male versus female preterm infants born to preeclamptic women. Our study underlined the importance of incorporating sex differences in the study of biological mechanisms for immediate- and long-term consequences of suboptimal fetal growth.
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- The end of an era: the final chapter of Gender Medicine. [Editorial]Gend Med. 2012 Dec; 9(6):389.GM
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- Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality. [Journal Article]
- CONCLUSIONS: Analyzing a large population-based sample, we observed that men have a generally higher risk of incident cardiovascular morbidity and mortality. Furthermore, men with low TT concentrations were identified as high-risk individuals with regard to 10-year CVD and mortality risk.
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- Sex and life expectancy. [Review]
- CONCLUSIONS: Despite noted gaps in sex equality, higher body fat percentages and lower physical activity levels globally at all ages, a sex-based gap in life expectancy exists in nearly every country for which data exist. There are several biological mechanisms that may contribute to explaining why females live longer than men on average, but the complexity of the human life experience makes research examining the contribution of any single factor for the female advantage difficult. However, this information may still prove important to the development of strategies for healthy aging in both sexes.
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- Mainstreaming sex and gender analysis in public health genomics. [Review]
- CONCLUSIONS: Including sex and gender analysis in PHG research will not only shed more light on phenomena such as diseases with a higher prevalence in either men or women, but will ultimately lead to gendered innovations by way of exploring how gendered and cultural environments increase or safeguard genetic predispositions.
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- A sex- and gender-based analysis of allostatic load and physical complaints. [Journal Article]
- CONCLUSIONS: That higher masculinity was related to increased objective physiological dysregulations and subjective physical complaints suggests an increased vulnerability to hyperarousal pathologies, such as cardiovascular disease, among masculine-typed individuals.
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- Sex of newborns associated with place and mode of delivery: a population-based study in northern Vietnam. [Journal Article]
- CONCLUSIONS: We demonstrated an elevated SRB, especially at district hospital level, and that sex of offspring influenced place and mode of delivery. Although mothers to boys were more likely to receive more qualified delivery care, they were at the same time more likely to undergo unnecessary surgery. Correct information to women and family members about CS and stricter implementation of the medical indications for CS are urgently called for.
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- Does sex affect 30-day mortality in Staphylococcus aureus bacteremia? [Journal Article]
- CONCLUSIONS: We found that women with S. aureus bacteremia had a greater risk of 30-day all-cause mortality than men, even when adjusting for other risk factors. However, we failed to explain this excess of mortality.
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- Gender differences in questions asked in an online preoperative patient education program. [Journal Article]
- CONCLUSIONS: Gender differences in concerns and physicians' ability to adequately address these concerns may contribute to disparity in use of hip and knee replacement surgery between men and women. Effective preoperative counseling for women may require additional resources to address their higher level of questions.
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- Tacrolimus as a part of immunosuppressive treatment in kidney transplantation patients: sex differences. [Journal Article]
- CONCLUSIONS: Our study shows that dose of corticosteroid affects Tac level in kidney transplantation patients. Tac dose and level changes showed that corticosteroid-Tac interaction has more influence on male than female patients. According to biochemical monitoring, the immunosuppressive therapy used at present is quite well tolerated.
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