- Blueberry Extract Has Anti-Proliferative Activity in Preclinical Models of Head and Neck Cancer. [Journal Article]Head Neck. 2026 Sep 06. [Online ahead of print]HN
- CONCLUSIONS: These findings suggest that BE may have some utility as an adjunct to standard therapies for HNSCC, with limited utility during early tumorigenesis but more efficacy at later stages of tumor progression.
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- A Pilot Clinical Trial of Cetuximab Combined With Tislelizumab as Neoadjuvant Therapy for Locally Advanced Oral Squamous Cell Carcinoma. [Journal Article]Head Neck. 2026 Sep 06. [Online ahead of print]HN
- CONCLUSIONS: Neoadjuvant cetuximab plus tislelizumab showed feasible delivery, encouraging antitumor activity, and acceptable safety in patients with locally advanced OSCC who were medically unsuitable for conventional cytotoxic chemotherapy.
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- Managing Periprosthetic Leakage After Tracheoesophageal Puncture With Carboxymethylcellulose Gel. [Journal Article]Head Neck. 2026 Sep 06. [Online ahead of print]HN
- CONCLUSIONS: This is the first study reporting the use of CMC gel for TEP tract augmentation. Despite variability in response duration, CMC gel was safe and resulted in immediate leak resolution in almost all cases, highlighting its potential utility in managing peripheral TEP leakage.
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- Level IA Nodal Involvement in Parotid Cutaneous Squamous Cell Carcinoma. [Journal Article]Head Neck. 2026 Sep 06. [Online ahead of print]HN
- CONCLUSIONS: Level IA metastasis is uncommon in advanced cSCC and occurs exclusively in high-burden nodal disease. These findings support selective omission of Level IA dissection in the clinically node-negative neck and the oncological safety of SIF in well-selected patients.
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- Outcomes of Curative-Intent Endoscopic Resection Combined With Adjuvant Immune Checkpoint Inhibition for Resectable Sinonasal Mucosal Melanoma. [Journal Article]Head Neck. 2026 Sep 06. [Online ahead of print]HN
- CONCLUSIONS: Recurrence was frequent and early, whereas overall survival remained preserved. Although efficacy cannot be inferred without a comparator, these data support multicenter evaluation of treatment sequencing and risk stratification.
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- Laryngopharyngeal Malakoplakia Mimicking Malignancy in a Patient With Diabetes Mellitus and Uremia: A Case Report and Literature Review. [Case Reports]Head Neck. 2026 Sep 04. [Online ahead of print]HN
- CONCLUSIONS: Malakoplakia should be considered in the differential diagnosis of a pharyngeal mass. Complete surgical excision could be an effective way to treat malakoplakia and patients need long-term follow-up.
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- Trismus and Health-Related Quality of Life in HNC Patients up to 10 Years Post-Radiotherapy Completion. [Journal Article]Head Neck. 2026 Sep 03. [Online ahead of print]HN
- CONCLUSIONS: Trismus continues to be present in up to 35% of patients 10 years post-RT as well as a reduced QOL, with no significant changes occurring between 5 and 10 years post-RT.
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- Complete Pathologic Response to Neoadjuvant Pembrolizumab Captured on Intraoperative PET/CT: A Case Report and Exploratory Analysis. [Case Reports]Head Neck. 2026 Sep 03. [Online ahead of print]HN
- CONCLUSIONS: In this case report of pCR, intraoperative micro-PET/CT demonstrated similar avidity at the primary tumor site compared to the tracheostomy site, highlighting the potential utility of this novel imaging approach in patients receiving neoadjuvant immunotherapy.
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- Bone-Anchored Implant Survival in Oncologic Facial Prosthetic Rehabilitation. [Journal Article]Head Neck. 2026 Sep 02. [Online ahead of print]HN
- CONCLUSIONS: Five-year survival in this oncologic cohort was half the published rate. Ongoing attrition supports supernumerary implant placement and lifelong management.
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- Characterization of Perineural Invasion Parameters for Risk Stratification in Oral Squamous Cell Carcinoma. [Journal Article]Head Neck. 2026 Sep 02. [Online ahead of print]HN
- CONCLUSIONS: PNI correlates with positive surgical margins. Quantifying PNI, particularly nerve diameter, enhances prognostic stratification and may inform individualized surgical margin planning in OSCC.
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- The Utility of Tumor Tissue-Modified Viral HPV DNA Testing for HPV-Associated Non-Oropharyngeal Squamous Cell Carcinoma of the Head and Neck. [Journal Article]Head Neck. 2026 Sep 01. [Online ahead of print]HN
- CONCLUSIONS: TTMV-HPV DNA testing demonstrated strong diagnostic and surveillance performance in HPV-associated non-OP HNSCC and may be a useful adjunct in posttreatment surveillance.
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- PET/CT Diagnostic Accuracy for Synchronous Primary HPV-Positive Oropharyngeal Tumors: A Multi-Institutional Study. [Journal Article]Head Neck. 2026 Aug 30. [Online ahead of print]HN
- CONCLUSIONS: PET/CT demonstrates excellent NPV for excluding synchronous primary tumors in HPV-positive OPSCC and moderate PPV for identifying them. In settings of multifocal fluorodeoxyglucose uptake, pathologic confirmation is warranted prior to definitive management.
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- Head and Neck Lymph Node Metastases From Cancer of Unknown Primary: Outcomes From p16-Guided Mucosal Radiotherapy. [Journal Article]Head Neck. 2026 Aug 28. [Online ahead of print]HN
- CONCLUSIONS: p16-guided mucosal volume reduction in HNCUP appears oncologically safe, without compromising disease control or survival, supporting radiotherapy volume de-intensification for p16-positive disease.
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- A Case of Rapidly Progressive DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma in Pregnancy. [Case Reports]Head Neck. 2026 Aug 28. [Online ahead of print]HN
- CONCLUSIONS: This case highlights potential aggressive behavior in DEK::AFF2 carcinoma and possible pregnancy-associated tumor acceleration.
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