- Cabergoline-induced SUNCT-like headache. [Letter]Headache. 2026 Sep 29. [Online ahead of print]H
- Publisher Full Text (DOI)
- Mitochondrial migraine: A multicenter study based on mitochondrial diseases presenting as encephalopathy and/or myopathy. [Journal Article]Headache. 2026 Sep 29. [Online ahead of print]H
- CONCLUSIONS: In patients with MD presenting as encephalopathy and/or myopathy, the 1-year frequency of migraine was more than five times higher than that in the general population. Epilepsy and elevated resting blood lactate concentration were identified as factors independently associated with migraine. In patients with MELAS, AHF positivity was associated with distinct and severe migraine phenotypes. Collectively, these findings offer clinical evidence supporting the potential link between migraine and mitochondrial dysfunction.
- Publisher Full Text (DOI)
- Anti-calcitonin gene-related peptide treatments in women's health: Gaps and clinical evidence in menstrual-related migraine, pregnancy, lactation, and hormonal contraception: A narrative review. [Review]Headache. 2026 Sep 29. [Online ahead of print]H
- CONCLUSIONS: Substantial evidence gaps exist across all reproductive health contexts examined. Prospective trials in menstrual-related migraine, pregnancy registries, lactation studies assessing infant outcomes, and research examining interactions with hormonal contraceptives are needed to optimize migraine care for women.
- Publisher Full Text (DOI)
- Guest editorial on "Anti-CGRP treatments in women's health: Gaps and clinical evidence in menstrual migraine, pregnancy, lactation, and hormonal contraception". [Editorial]Headache. 2026 Sep 29. [Online ahead of print]H
- Publisher Full Text (DOI)
- Orofacial pain disorder or trigeminal autonomic cephalalgia? Insights into pathophysiology and implications in medicine and dentistry. [Review]Headache. 2026 Sep 28. [Online ahead of print]H
- CONCLUSIONS: The potential presence of TACs in the orofacial region can be observed from preclinical models to the clinical setting. The International Classification of Headache Disorders (ICHD) needs to recognize this additional localization, as well as the intraoral one, including dental structures. Education about TACs/TAOPs in the medical and dental setting is vital. Evidence has shown that dentists are one of the first providers that are seen by this patient population due to similarities with dental pain. The dentist specialized in orofacial pain is a key ally in the identification of TACs/TAOPs. The medical/neurology and dental/orofacial pain settings have a great opportunity and responsibility to work together to stop years of pain in this patient population.
- Publisher Full Text (DOI)
- Re-evaluation of the dinosaur tail sign: Analysis of spinal magnetic resonance imaging signs in patients with chronic post-dural-puncture headache. [Journal Article]Headache. 2026 Sep 28. [Online ahead of print]H
- CONCLUSIONS: The dinosaur tail sign, originally described in patients with acute post-dural-puncture headache (≤14 days persistence), was unable to reliably distinguish patients with chronic post-dural-puncture headache from healthy controls. Other findings, such as arachnoid blebs or extradural fluid collections, were only present in chronic post-dural-puncture headache, but rare. Contrast enhancement in the lumbar spine was found in approximately one third of patients but was mostly attributed to nonspecific findings. Further spinal MRI signs need to be identified to enable diagnosis of chronic post-dural-puncture headache in the future.
- Publisher Full Text (DOI)
- Novel targets in headache: A narrative review. [Review]Headache. 2026 Sep 28. [Online ahead of print]H
- CONCLUSIONS: Altogether, these emerging targets expand the therapeutic landscape for headache disorders beyond CGRP and support a shift toward alternative, sex-informed, and potentially combinatorial approaches for headache prevention and treatment, with the potential to benefit the untreated portion of patients.
- Publisher Full Text (DOI)
- The association between sleep duration and migraine frequency, disability, and perceived stress in the Headache Assessment via a Digital Platform in United States (HeAD-US) study. [Journal Article]
- CONCLUSIONS: Unhealthy sleep duration, particularly long sleep, is associated with greater migraine burden, characterized by increased headache frequency and disability. Perceived stress statistically accounted for part, but not all, of the observed associations between nonoptimal sleep duration and migraine burden.
- Publisher Full Text (DOI)
- In reply to: "Spontaneous intracranial hypotension and autonomic dysfunction association highlights POTS as a central nervous system disorder". [Letter]Headache. 2026 Sep 28. [Online ahead of print]H
- Publisher Full Text (DOI)
- Distribution and target engagement of peripherally administered fremanezumab in the cerebrospinal fluid of healthy volunteers. [Journal Article]Headache. 2026 Sep 23. [Online ahead of print]H
- CONCLUSIONS: The present findings suggest the rapid distribution of fremanezumab into the central nervous system after peripheral administration, and the persistent retention of fremanezumab and target engagement of CGRP in the CSF. Further studies are required to determine whether entry into the CSF and target engagement play a role in the clinical efficacy of fremanezumab observed in people with migraine.
- Publisher Full Text (DOI)
- Self-administered medication devices' environmental waste consequences. [Journal Article]Headache. 2026 Sep 22. [Online ahead of print]H
- Publisher Full Text (DOI)
- Early improvements in function with atogepant as assessed by the Activity Impairment in Migraine-Diary: Post hoc analyses of three randomized, phase 3 clinical trials of atogepant for the preventive treatment of migraine. [Journal Article]Headache. 2026 Sep 22. [Online ahead of print]H
- CONCLUSIONS: For preventive migraine treatment, atogepant once daily versus placebo was associated with early improvements in AIM-D individual and activity limitation items and with higher odds of achieving complete improvement for AIM-D domain scores in people with EM and CM, demonstrating early functional improvements across the migraine spectrum.
- Publisher Full Text (DOI)
- Patterns of head and neck pain and obstructive sleep apnea in women with macromastia: A cross-sectional analysis. [Journal Article]Headache. 2026 Sep 22. [Online ahead of print]H
- CONCLUSIONS: In our retrospective, cross-sectional study, compared to women without macromastia, women with macromastia had a higher prevalence of chronic migraine, neck pain, cervical radiculopathy, and OSA. Women with macromastia and neck pain were more likely to have breast reduction surgery compared to women with macromastia without neck pain. Prospective, longitudinal studies are needed to clarify potential mechanisms driving macromastia's impact on migraine and other disorders and to assess the impact of macromastia treatment on headache outcomes.
- Publisher Full Text (DOI)
- Spontaneous intracranial hypotension and autonomic dysfunction association highlights postural orthostatic tachycardia syndrome as a central nervous system disorder. [Letter]Headache. 2026 Sep 17. [Online ahead of print]H
- Publisher Full Text (DOI)
- Hormonal treatments and migraine characteristics across reproductive stages and transition to menopause: A cross-sectional study. [Journal Article]Headache. 2026 Sep 15. [Online ahead of print]H
- CONCLUSIONS: In this real-world cohort of females with migraine, stable HT was not clearly associated with differences in migraine phenotype or preventive treatment patterns across reproductive stages. Menstrually-related migraine was highly prevalent, and the menopause transition represented a period of vulnerability in a subset of patients. Larger and prospective studies are needed to confirm these findings.
- Publisher Full Text (DOI)