Excessive hair shedding continues to be a major concern for individuals, negatively affecting their wellbeing and confidence. This research analysed 12 clinical studies involving 805 participants (323 males and 482 females) across eight countries (China, Indonesia, UK, India, Brazil, Thailand, Turkey and US) with concerns about hair loss. Two recent studies in China and a study in Indonesia were investigated in depth, focusing on hair shedding and breakage conditions, and age-related differences in hair shedding. The two China studies were further investigated in hair shedding during different scalp or hair care procedures (washing, drying, and combing after drying). Additionally, nine historical clinical studies from various regions were further reviewed for hair shedding and breakage conditions to provide a global view on this topic. Across the three recent Asian studies, whilst total hair fall comprised both shed hairs from the root (exogen hairs with a typical club end) and broken hairs, shed hairs from the root represented the predominant proportion, accounting for an average of 96.5% of total hair fall in Chinese female participants, 98.8% in Chinese male participants, and 72.2% in Indonesian female participants. Analysis of the nine historical studies supported the insight that shed hairs from the root are more than broken hairs. Regardless of region or gender, more shed hairs from the root were collected from scalp than broken hairs, with shed hair proportions ranging from 67.1% to 97.7%. Data mining of the two recent Chinese studies revealed that most hair shedding occurred during the washing stage (49.6% in females and 74.1% in males), followed by drying and combing after drying. Further analysis of the 2 recent Chinese studies and the recent Indonesian study also explored the differences in hair shedding with age. Spearman correlation analysis showed an increasing trend of hair shedding with age in female participants. Subgroup analysis of younger (18-42 years) and older participants (>42 years) using the Mann-Whitney U test also indicated increased hair shedding with age in females.

To accurately identify early destabilization signals in emulsions, this study employed multiple light scattering (MLS) technology combined with microscopic observation, particle size analysis and long-term macroscopic stability tests to perform a multi-scale evaluation on a series of emulsions. By comparing the migration of the transmission light inflection point, the average rate of change of backscattered light intensity (BSMRC) and the uniformity index (U) of samples under different temperatures, the intrinsic correlation between MLS signals and emulsion stability was systematically analysed. The results indicated that three typical destabilization phenomena can be predicted based on the characteristics of the inflection point changes. Further dynamic tracking of BSMRC and U revealed that for stable samples, both BSMRC and U remained at low levels. During destabilization at high temperature (45°C), a significant increase in BSMRC served as a precursor indicator of phase separation. During destabilization at low temperature (-16°C), the U value markedly increased while BSMRC changed gradually, reflecting mechanical damage induced by freezing. In conclusion, multiple light scattering technology can capture destabilization signals in emulsions in advance, with sensitivity superior to traditional visual observation, thereby providing an efficient and reliable technical approach for formulation screening and long-term stability prediction of emulsions.