- Seeing the Bias: Hemifield‑Dependent Remapping of Sensory, Sighting, and Acuity Eye Dominance. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):66.IO
- CONCLUSIONS: Sensory and sighting eye dominance are not uniform across the visual field. We speculate that both tap into binocular combination processes at the primary visual cortex (V1), where the contralateral eye is weighted more strongly due to structural asymmetries across the visual pathway. In contrast, acuity dominance likely reflects monocular optical and retinal factors independent of binocular interactions, explaining its spatial invariance and weak correlations with other dominance metrics. Our results suggest that the clinical convention of relying on a single foveal test (e.g., hole-in-the-card or Porta) cannot capture an individual's dominant eye across the visual field or across sensory, sighting, and acuity dimensions.
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- Lipid Peroxidation Increases Lens Stiffness and Is Associated With αA-Crystallin Accumulation at the Plasma Membrane: An Ex Vivo Study. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):67.IO
- CONCLUSIONS: This ex vivo organ-culture model provides direct evidence that lipid peroxidation is sufficient to induce cataract-relevant lens stiffening and opacification, accompanied by crystallin-membrane association and protein aggregation. These findings establish lipid peroxidation as a key contributor to cataract-associated optical, mechanical, and biochemical changes.
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- Elevated Intraocular Pressure Facilitates T-Cell-Mediated Retinal Ganglion Cell Loss. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):68.IO
- CONCLUSIONS: These findings indicate that mild EIOP promotes T-cell-mediated degeneration of RGCs, particularly in the central retina. LPS-mediated disruption of the blood-retina barrier alone did not induce RGC loss, indicating that IOP-dependent processes may be required to breach the immune-protective environment of the retina. The increase in Vcam1 expression in EIOP retinas may represent a mechanism facilitating T-cell-mediated retinal neurodegeneration.
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- Latent Correlations Between Longitudinal Systemic Complement Factors and Geographic Atrophy Growth Rate. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):69.IO
- CONCLUSIONS: Systemic alternative pathway biomarkers demonstrated the strongest positive associations with GA growth rate. The pattern of associations in this exploratory analysis supports a hypothesis-generating framework in which differences in alternative pathway regulation may be associated with heterogeneity in GA progression. Future larger studies are needed for external validation of this hypothesis-generating work.
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- Retinal Microvascular and Neuronal Alterations in Type 2 Diabetes: Insights From a Population-Based Screening Program (START2). [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):61.IO
- CONCLUSIONS: Combined central and peripheral lesions are associated with greater microvascular impairment. Age and glycemic control are key determinants of early retinal microvascular changes in T2DM, and age and body mass index relate to GCL-IPL thickness, highlighting the need for a multidisciplinary approach to improve early detection, risk stratification, and ocular and systemic management.
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- AI-Based OCT Assessment of Anatomic Response During the Loading Phase of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration. [Multicenter Study]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):62.IO
- CONCLUSIONS: All agents improved functional and anatomic outcomes after the loading phase in treatment-naive nAMD. Baseline-adjusted analyses showed differences in anatomic response patterns across treatments. Exploratory AI-based OCT biomarkers may help characterize short-term anatomic response; however, these findings require external validation.
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- CLEC4E-Mediated Macrophage Activation Contributes to Host Defense in Acanthamoeba Keratitis. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):63.IO
- CONCLUSIONS: CLEC4E promotes macrophage activation and contributes to protective innate immune responses during Acanthamoeba infection. HIF-1α mediates CLEC4E-dependent inflammatory amplification, highlighting a potential link between CLEC4E signaling and macrophage inflammatory programs during AK.
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- Association Between Cilio-Lenticular Distance and Anterior Chamber Depth in Primary Angle-Closure Glaucoma. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):64.IO
- CONCLUSIONS: A smaller CLD correlates with a shallow anterior chamber and indicates a more crowded ciliary-lens configuration, a crucial indictor of PACG.
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- Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma: A Multidimensional Genome-Wide Analysis. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):65.IO
- CONCLUSIONS: Myopia and POAG exhibit a significant genetic correlation, substantial polygenic overlap, and multiple shared susceptibility loci and genes. Their comorbidity is likely driven by convergent developmental and biomechanical pathways. These findings provide novel insights into the genetic basis of myopia-POAG comorbidity and may facilitate future mechanistic studies and risk stratification.
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- Integrative Genomic Analyses Prioritize CETP-Related Lipid Traits in Age-Related Macular Degeneration. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):54.IO
- CONCLUSIONS: Across discovery and replication cohorts, this multi-cohort, multi-method study prioritized CETP as a genetically supported candidate effector gene for AMD and implicates HDL-C-related genetic variation at the CETP locus in AMD susceptibility and exploratory progression outcomes. These findings support the potential relevance of CETP-related lipid biology but require further mechanistic validation.
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- Longitudinal Data on Chinese Children Suggest That Cutoff Values for Defining Premyopia Should Be Age- and Location-Specific. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):55.IO
- CONCLUSIONS: The optimal SER cutoff for predicting future myopia onset depends on age and population. In Chinese children, +1.00 D is a more appropriate cutoff value for defining premyopia among children in the early years of primary school.
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- The Relationship Between Interocular Lag and Contrast Sensitivity in Amblyopia. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):56.IO
- CONCLUSIONS: We demonstrated that the IOLag depends on SF in amblyopia. In addition, we found that this temporal imbalance of amblyopia was linked with their spatial imbalance. This temporal asynchrony in amblyopia should not be ignored in amblyopic visual deficits and vision rebuilding.
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- Association Between Ellipsoid Zone Area and Fixation Stability in Macular Telangiectasia Type 2. [Randomized Controlled Trial]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):57.IO
- CONCLUSIONS: Greater EZ area loss is associated with poorer fixation stability in MacTel. An EZ area loss threshold of ∼1 mm[2] may serve as an exploratory marker of fixation instability risk, though this threshold requires independent validation.
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- Quantitation of Stromal Distortion Across the Full Depth of Keratoconic Corneas. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):58.IO
- CONCLUSIONS: We provide new quantitative data on the structural alterations associated with keratoconus that could serve as useful biomarkers for earlier detection. Our findings are consistent with a decreased stromal stiffness and an increase in the corneal birefringence. They are also in favor of a global stromal disorder rather than a purely localized disorder.
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- Genetic and Clinical Characterization of Early-Onset High Myopia With or Without Cataract Due to Biallelic P3H2 Variants. [Journal Article]Invest Ophthalmol Vis Sci. 2026 Oct 01; 67(12):59.IO
- CONCLUSIONS: Biallelic P3H2 variants represent relatively common causes of autosomal-recessive eoHM, with a frequency comparable with LOXL3- and LRPAP1-associated eoHM. The distinct lens phenotype and refractive-axial dissociation are hallmarks of biallelic P3H2 variants.
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