- Improved Visualization of Heart Valves With 4D-CT Using a Novel Motion Correction Algorithm. [Journal Article]Invest Radiol. 2026 Oct 12. [Online ahead of print]IR
- CONCLUSIONS: A novel motion correction algorithm substantially reduced motion artifacts and improved image quality in both native and prosthetic heart valve imaging with PCD-CT, with the largest improvements in systole. These benefits resulted in enhanced visualization of valvular pathology, potentially reinforcing the growing clinical role of cardiac CT for the assessment of valve disease.
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- The Effect of Different Gadolinium Delivery Rates on Objective and Subjective Image Quality in Cardiac Perfusion Magnetic Resonance Imaging. [Journal Article]Invest Radiol. 2026 Oct 08. [Online ahead of print]IR
- CONCLUSIONS: Higher GBCA injection rates resulted in higher blood-pool peak enhancement, yet did not translate into significant differences in objective image and subjective image quality. Lower injection rates appear sufficient to achieve adequate myocardial perfusion imaging, suggesting a plateau in image quality in which increasing flow rates do not show added benefit.
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- Gadopiclenol for Cardiac MRI: Comparison of Myocardial T1 Relaxation Times and Subjective Image Quality at Different Doses in Patients With Anderson-Fabry Disease. [Journal Article]Invest Radiol. 2026 Sep 25. [Online ahead of print]IR
- CONCLUSIONS: In this retrospective 3 T AFD cohort, gadopiclenol provided high LGE image quality at both dose levels. While 0.1 mmol/kg produced slightly stronger qualitative and quantitative contrast effects, 0.05 mmol/kg remained technically feasible. These preliminary findings support that dose reduction to 0.05 mmol/kg gadopiclenol may be feasible in CMR. However, validation through prospective studies is needed before recommending lower-dose gadopiclenol broadly in routine CMR.
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- Gadolinium-based Contrast Agents Trigger Gadolinium Accumulation Within the Hippocampus In Vivo and Mitochondrial Alterations in Organotypic Hippocampal Tissue Cultures Ex Vivo. [Journal Article]Invest Radiol. 2026 Sep 21. [Online ahead of print]IR
- CONCLUSIONS: In the hippocampus, long-term Gd retention in vivo appears to be restricted to linear GBCAs, whereas ex vivo, exposure to both linear and macrocyclic GBCAs at biologically relevant concentrations alters neuronal mitochondrial morphology and dynamics. Inflammation further amplifies these effects, highlighting the importance of considering GBCA-associated mitochondrial damage when evaluating their potential neurotoxic risks, particularly in neuroinflammatory diseases.
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- Influence of X-ray Tube Voltage on Computed Tomography Values and Contrast-Noise Ratios in Virtual Monoenergetic Images in routine clinical Photon Counting Detector Computed Tomography: Does kV Still Matter? [Journal Article]Invest Radiol. 2026 Sep 15. [Online ahead of print]IR
- CONCLUSIONS: In VMIs acquired with PCD-CT, CT values were stable within the predefined 10% tolerance for all phantom sizes and tube voltages in the energy range of 45 to 70 keV, which is relevant for contrast-enhanced CT. This represents a significant step towards the meaningful comparison of CT values across different CT scans. At low keV and small phantom sizes, scans at 70 or 90 kV demonstrated greater radiation dose efficiency compared with scans at 120 or 140 kV. Therefore, for routine contrast-enhanced CT examinations of small patients or small body parts (eg, CTA of the head), scanning at low tube voltage may be considered if no spectral results other than VMIs are required.
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- The Challenge of Rendering Abnormalities Accurately Using Deep Learning-Based Reconstruction in Accelerated Brain MRI: A Disproportionate Loss of Clinically Relevant Image Information at Higher Rates of Acceleration. [Journal Article]Invest Radiol. 2026 Sep 14. [Online ahead of print]IR
- CONCLUSIONS: Our findings demonstrate a disproportionate, pathology-localized degradation of reconstruction quality as acceleration increases. This emphasizes the importance of rigorous clinical assessment of image quality in DL-MRI reconstruction, particularly at higher undersampling rates, highlighting the need for reconstruction strategies tailored to maintaining diagnostically critical features.
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- Deep Learning-Based Distortion Correction for Brain Diffusion-weighted Imaging: A Prospective Comparison With Single-shot and Readout-segmented Echo-planar Imaging. [Journal Article]Invest Radiol. 2026 Sep 09. [Online ahead of print]IR
- CONCLUSIONS: DL DWI improved image quality and geometric accuracy compared with uncorrected ss-EPI DWI. Subjective lesion-detectability ratings were similar between DL DWI and RESOLVE DWI, while DL DWI required less than half the acquisition time. These findings support DL-based distortion correction as a promising, time-efficient approach for brain diffusion-weighted imaging that warrants confirmation in a predefined noninferiority design.
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- Accelerated Body Composition Analysis in Whole-body MRI Using CycleGAN-based T2-HASTE Synthesis From Fast Whole-body Localizers. [Journal Article]Invest Radiol. 2026 Sep 07. [Online ahead of print]IR
- CONCLUSIONS: Combining FWBL MRI with CycleGAN-based image synthesis yielded BCA measurements that closely matched those from reference T2-HASTE images and largely preserved body composition stratification. These findings demonstrate the feasibility of deriving quantitative BCA information from routinely acquired WB-MRI localizer data and support further investigation of accelerated MRI-based BCA approaches using simplified acquisitions.
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- Optimizing Brachial Plexus Diffusion Tensor Imaging: The Impact of Deep Learning Reconstruction and Simultaneous Multislice Acceleration on Single-shot Echo-planar Imaging. [Journal Article]Invest Radiol. 2026 Nov 01; 61(11):774-789.IR
- CONCLUSIONS: DL reconstruction significantly improves the feasibility and reliability of BP DTI and affects quantitative metrics in an anatomy-specific manner. In contrast, the integration of SMS acceleration with single-shot EPI remains technically challenging in the high-susceptibility BP region. Our findings underscore that anatomy-specific optimization is essential for successful clinical integration of DL-enhanced DTI.
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- Spectral Black-Blood Photon-Counting CT for High-Resolution Carotid Vessel Wall Imaging: A Feasibility Study. [Journal Article]Invest Radiol. 2026 Aug 18. [Online ahead of print]IR
- CONCLUSIONS: Spectral BBCT was feasible for high-resolution carotid vessel wall imaging, with preserved overall image quality, improved wall-lumen delineation, and higher plaque conspicuity compared with conventional CTA. Improved agreement for selected plaque features supports its potential as a complementary vessel wall reconstruction; however, possible subtraction-related sensitivity loss suggests BBCT should be interpreted in conjunction with conventional CTA rather than as a standalone reconstruction.
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- Perception‑based, Nonuniform Color Mapping for CT Reading. [Journal Article]Invest Radiol. 2026 Aug 04. [Online ahead of print]IR
- CONCLUSIONS: Unlike uniform color mappings, the proposed approach uses nonuniform color ranges to better match human perception. In CT, this may facilitate visual separation of tissues and structures and was preferred in phantom‑based visual assessment compared with standard uniform display methods.
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- Accelerated 7T 3D DESS MR Neurography of the Cervical Spine Using CS-CAIPIRINHA and Deep Learning Reconstruction. [Journal Article]Invest Radiol. 2026 Jul 24. [Online ahead of print]IR
- CONCLUSIONS: Coherent CAIPIRINHA undersampling with DL reconstruction improves image quality over conventional GRAPPA while enabling 50% faster imaging in 7T cervical spine MRI. Adding incoherent CS undersampling permits substantially higher acceleration with preserved image quality and fewer reconstruction artifacts. The novel integration of coherent and incoherent undersampling via combined CAIPIRINHA and CS with DL reconstruction provides a robust framework for preserving image quality at acceleration factors beyond 8, enabling efficient high-resolution cervical spine MRI with scan time reductions exceeding 6-fold.
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- Ultra-High-Resolution Dual-Source Photon-Counting CT for Expanded Characterization of Pathophysiological Imaging Patterns in Multiple Myeloma. [Journal Article]Invest Radiol. 2026 Jul 16. [Online ahead of print]IR
- CONCLUSIONS: DS-PCCT identified a previously undescribed fat-attenuation-predominant imaging phenotype in MM that meets criteria for symptomatic bone disease but is not captured by current International Myeloma Working Group definitions of focal lesions. Spectral-morphologic characterization of marrow involvement may complement existing imaging criteria and aid differentiation between overt MM and nonspecific marrow abnormalities.
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- Elastin-Specific Molecular Magnetic Resonance Imaging Reveals Spatiotemporal Extracellular Matrix Remodeling at the Tumor-Stroma Interface During Prostate Cancer Progression. [Journal Article]Invest Radiol. 2026 Jul 15. [Online ahead of print]IR
- CONCLUSIONS: ESMA-enhanced molecular MRI captures the longitudinal dynamics of elastin accumulation during PCa progression. Progressive elastin deposition, concentrated at the tumor periphery, is consistent with active ECM remodeling at the invasive front and suggests elastin as a candidate imaging biomarker for monitoring matrix-driven tumor progression.
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