(JACC[TA])
63,359 results
  • Junctional Rhythm as Reversible Driver of Fontan Failure: Recovery With Multimodal Therapy Including Atrial Pacing. [Case Reports]
    JACC Case Rep. 2026 Sep 26; :110541. [Online ahead of print]Kozłowski M, Dąbrowski M, … Kansy AJC
  • CONCLUSIONS: In patients with failing Fontan circulation and junctional rhythm, restoring AV synchrony by atrial pacing may reverse Fontan hypertension and improve end-organ congestion.Junctional rhythm should be considered a reversible contributor to elevated Fontan pressures before attributing failure to anatomy. Atrial pacing, when AV conduction is intact, can improve Fontan hemodynamics and hepatic congestion while avoiding ventricular pacing.
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  • Group A Streptococcal Perimyocarditis Presenting With Acute Left Ventricular Dysfunction. [Case Reports]
    JACC Case Rep. 2026 Aug 12; :109735. [Online ahead of print]Belkin DL, Zhang DT, … Hellerman MBJC
  • CONCLUSIONS: Nonrheumatic GAS-associated perimyocarditis is a rare inflammatory cardiac complication of streptococcal pharyngitis that may present with chest pain, myocardial injury, and left ventricular dysfunction.GAS-associated perimyocarditis should be considered in patients presenting with acute chest pain and left ventricular dysfunction shortly after streptococcal pharyngitis. Recognition of this syndrome is important to guide appropriate diagnostic evaluation, including exclusion of obstructive coronary disease and utilization of multimodality imaging.
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  • Vancomycin-Induced Type I Kounis Syndrome Mimicking Acute Inferolateral STEMI Prior to Spine Surgery. [Case Reports]
    JACC Case Rep. 2026 Sep 26; :110542. [Online ahead of print]Alzahrani Z, Alyacoub RJC
  • CONCLUSIONS: This case highlights the importance of early recognition of allergic acute coronary syndrome, especially when cardiac symptoms occur during an anaphylactic reaction. Epinephrine, which is essential for anaphylaxis, can potentially worsen coronary vasospasm. Emergent angiography plays a critical role in distinguishing KS subtypes.KS should be suspected in any perioperative patient developing ST elevation after drug administration; emergent angiography is essential to differentiate vasospasm from obstructive disease and guide management.
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  • Complete AV Block From Septal Cardiac Metastases of Anal Squamous Carcinoma Managed With Leadless Pacing. [Case Reports]
    JACC Case Rep. 2026 Sep 26; :110522. [Online ahead of print]Venditti E, Ialungo S, … Colloca GFJC
  • CONCLUSIONS: Septal metastatic infiltration was the most likely cause of the AV block. New conduction disease in patients with cancer warrants multimodality imaging to assess cardiac involvement.Leadless pacing can be a practical option for complete AV block in frail oncology patients. Cardiac metastases should be considered in new arrhythmias or conduction disturbances, particularly with septal lesions.
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  • Native T1 for Diagnosis and Risk Prediction in Amyloid Transthyretin Cardiomyopathy: An Observational Study on 1,675 Subjects. [Journal Article]
    JACC Cardiovasc Imaging. 2026 Sep 24. [Online ahead of print]Aimo A, Sheikh A, … Fontana MJC
  • CONCLUSIONS: Native T1 can provide pragmatic diagnostic supportive thresholds, whereas ECV-calibrated native T1 strata reproduced a graded 3-year mortality risk. Native T1 offers a practical contrast-free approach to support diagnosis and risk stratification, although ECV remains the preferred quantitative marker when contrast CMR is available. Thresholds and z-score based approaches still require local recalibration and external validation before adoption at other centers.
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  • Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Pathway in High-Risk Lymphocytic Acute Myocarditis. [Journal Article]
    JACC Adv. 2026 Sep 24; 5(10 Pt 2):103254. [Online ahead of print]Ammirati E, Gallone G, … Klingel KJA
  • CONCLUSIONS: PD-L1 is overexpressed in cardiomyocytes of patients with LAM compared with non-Infl-CMP or focal non-lymphocytic myocarditis, such as CS, suggesting that cardiac PD-L1 expression is likely a response to T-cell-mediated injury. PD-1 expression is blunted in infiltrating inflammatory cells in LAM compared with ACR, suggesting a disruption of the PD-L1/PD-1 axis in LAM.
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