- Workforce Culture and Engagement: Evolving the American College of Cardiology's Approach to Professional Excellence in Cardiovascular Medicine. [Editorial]JACC Adv. 2026 Oct 16; 5(11 Pt 2):103343. [Online ahead of print]JA
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- ANOCA Patients With Prior Obstructive Coronary Artery Disease and PCI Have Higher Odds of Epicardial Spasm. [Journal Article]JACC Adv. 2026 Sep 22; 5(11 Pt 2):103319. [Online ahead of print]JA
- CONCLUSIONS: Among ANOCA patients, those with prior obstructive CAD treated with PCI had over a 4-fold higher odds of epicardial spasm. These findings underscore the need for comprehensive ICFT in ANOCA patients with prior PCI.
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- Minding the Gap: Follow-Up Cardiovascular Care After Clonal Hematopoiesis Detection. [Editorial]JACC Adv. 2026 Oct 16; 5(11 Pt 2):103357. [Online ahead of print]JA
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- Atrial Septostomy and Left Ventricular Venting During Peripheral VA-ECMO. [Journal Article]JACC Adv. 2026 Oct 16; 5(11 Pt 2):103344. [Online ahead of print]JA
- CONCLUSIONS: Among patients receiving peripheral VA-ECMO for CS, BAS achieves atrial-level decompression and may provide durable LV venting in select patients, although venting failure remains common. Observed arterial pulse-pressure trajectories differed according to eventual LV venting failure status.
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- Calcium Density as a Marker of Coronary Plaque Stabilization in Primary Prevention: The CAUGHT-CAD Trial. [Journal Article]JACC Cardiovasc Imaging. 2026 Oct 15. [Online ahead of print]JC
- CONCLUSIONS: In asymptomatic, intermediate-risk individuals, statin treatment was associated with a shift toward higher density calcium within coronary plaques, most marked with effective lowering of LDL-C. (Coronary Artery Calcium Score: Use to Guide Management of Hereditary Coronary Artery Disease [CAUGHT-CAD]; ACTRN12614001294640).
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- Optimizing Echocardiographic Evaluation of Chronic Mitral Regurgitation: Comparison With Cardiac Magnetic Resonance Imaging and Implications for Guideline Recommendations. [Journal Article]JACC Cardiovasc Imaging. 2026 Oct 15. [Online ahead of print]JC
- CONCLUSIONS: Certain ASE criteria, especially when used in combination, are highly specific for diagnosing severe MR, even when <4 criteria are present. This study suggests that in many cases, the reliance on extensive quantification may be reduced, streamlining the diagnostic process and improving clinical workflow.
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- Left Ventricular Filling Pressure Classification by Electrocardiogram, Echocardiography, and Catheterization: Prognostic Implications. [Journal Article]JACC Cardiovasc Imaging. 2026 Oct 12. [Online ahead of print]JC
- CONCLUSIONS: Despite moderate agreement with PAWP, echocardiography and AI-ECG showed stronger associations with clinical outcomes, suggesting they capture prognostically relevant myocardial information beyond resting hemodynamic status.
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- Assessment of Severity of Chronic Aortic Regurgitation: Importance of a Hierarchical Approach to Echocardiogram Doppler Parameters. [Letter]JACC Cardiovasc Imaging. 2026 Oct 15. [Online ahead of print]JC
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- IVUS-Guided Tip Detection and Distal Anchor Assisted Stent Push for a Protruding Ostial Stent. [Case Reports]JACC Case Rep. 2026 Oct 16; :110771. [Online ahead of print]JC
- CONCLUSIONS: The IVUS-guided TD method combined with a distal anchor balloon-supported stent push technique is an effective strategy for managing excessive aorto-ostial stent protrusion.
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- First-in-Human Permanent Totally Leadless Left Ventricular Septal Endocardial Pacing With Atrioventricular Synchrony. [Case Reports]JACC Case Rep. 2026 Oct 16; :110628. [Online ahead of print]JC
- CONCLUSIONS: This case demonstrates proof of concept for a fully leadless atrioventricular-synchronized system capable of delivering left ventricular septal endocardial pacing without right ventricular pacing dependency, offering a physiological pacing strategy for selected patients.This novel totally leadless architecture is a proof of concept for a more physiological pacing option for pacing-dependent patients while avoiding transvenous lead-related complications.
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- Successful Guidewire-Guided Ethanol Ablation for PVCs Originating From Epicardial Anterior Interventricular Groove Adjacent to LAD. [Case Reports]JACC Case Rep. 2026 Oct 16; :110992. [Online ahead of print]JC
- CONCLUSIONS: Epicardial PVCs arising within the anterior interventricular groove where the LAD runs carry a high risk of coronary artery injury during ablation. Guidewire-assisted anhydrous ethanol ablation serves as an effective and safe therapeutic strategy.
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- Tachycardia Initiation by Dual-Mode PVC on Ambulatory ECG: Pattern Discovery and Invasive Electrophysiological Characteristics. [Case Reports]JACC Case Rep. 2026 Oct 16; :110736. [Online ahead of print]JC
- CONCLUSIONS: To our knowledge, this is the first reported case of SS-AVNRT to show distinctive PVC-induced tachycardia patterns on ambulatory ECG, corroborated by EPS.Ambulatory ECG patterns of PVC-triggered long-RP tachycardia may suggest a dual-pathway substrate for SS-AVNRT, warranting EPS confirmation.
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- Transcatheter Adrenal Arterial Embolization for Life-Threatening Pheochromocytoma Crisis. [Case Reports]JACC Case Rep. 2026 Oct 16; :110993. [Online ahead of print]JC
- CONCLUSIONS: In this case, TAAE served as a minimally invasive bridging measure for refractory pheochromocytoma crisis. The staged strategy combining TAAE with delayed elective adrenalectomy was associated with a favorable outcome.
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- Coronary Visual Intelligence System (CorVIS) Guided Complex Percutaneous Coronary Intervention. [Case Reports]JACC Case Rep. 2026 Oct 16; :110994. [Online ahead of print]JC
- CONCLUSIONS: These cases suggest that artificial intelligence-based 3D CCTA reconstruction may complement conventional imaging for preprocedural planning of complex PCI. The efficacy of CorVIS in facilitating complex PCI remains to be verified in further prospective studies.In this initial case series, CorVIS delivered freely rotatable 3D CCTA reconstructions and plaque characterization, informing key procedural decisions for complex PCI.
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- Recurrent In-Stent Restenosis and Accelerated Neoatherosclerosis in a Middle-Aged Woman With High Inflammatory Burden. [Case Reports]JACC Case Rep. 2026 Oct 16; :110991. [Online ahead of print]JC
- CONCLUSIONS: Literature highlights that targeting upstream inflammation is critical when standard therapies fail to halt malignant neoatherosclerosis. This case interests readers by demonstrating compliance optimization via long-acting agents and navigating advanced anti-inflammatory pathways (colchicine escalation, canakinumab) for refractory ISR.Biomarkers like interleukin-6 must be evaluated in refractory ISR; persistent residual inflammation warrants advanced anti-inflammatory therapies or early surgical revascularization.
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